[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100490537":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":30,"locations":38,"responsibleParty":52,"collaborators":56,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":25,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":25,"enrollmentInfo":71,"targetDuration":25,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":25,"overallStatus":80,"whyStopped":25,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"First People's Hospital of Hangzhou","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"disulfiram and cisplatin","EXPERIMENTAL","Cisplatin combined with disulfiram chemotherapy",[13],"Drug: disulfiram and cisplatin",{"label":15,"type":16,"description":17,"interventionNames":18},"standard cisplatin","ACTIVE_COMPARATOR","Cisplatin chemotherapy alone",[19],"Drug: cisplatin",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","on the first day of treatment, patients were given intravenous drip of 80mg\u002Fm2 cisplatin, and 21 days was a course of treatment, lasting for 6 courses. Take 400mg disulfiram orally every day, and continue to use it until the end of chemotherapy. According to the patient's tolerance to disulfiram, the dose of disulfiram can be re-evaluated during the treatment, and the lowest dose is 125mg per day. The clinical symptoms, signs and adverse reactions of patients were observed, and the treatment effect of patients was evaluated after two consecutive cycles with 3 weeks as a cycle.",[9],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"cisplatin","on the first day of treatment, patients were given 80mg\u002Fm2 cisplatin intravenously, and 21 days was a course of treatment, lasting for 6 courses.",[15],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Hongzhang Shen","CONTACT","057156005600","sakshen@126.com",{"name":37,"role":33,"phone":34,"phoneExt":25,"email":25},"Xiaofeng Zhang",[39],{"facility":40,"status":25,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":25},"Hangzhou first people's Hospital","Hangzhou","Zhejiang","310000","China","CN",{"type":47,"coordinates":48},"Point",[49,50],120.16142,30.29365,{"lat":50,"lon":49},{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Zhang Xiaofeng,MD","chief physician",[57,60],{"name":58,"class":59},"College of Pharmaceutical Sciences at Zhejiang University","UNKNOWN",{"name":61,"class":59},"The Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University","100490537","treatment-of-advance-gastric-cancer-with-disulfiram-100490537",false,"NCT05667415","Treatment of Advance Gastric Cancer With Disulfiram","Clinical Study of Disulfiram Combined With Cisplatin in the Treatment of Advanced Gastric Cancer","1. Inclusion criteria: ① Age ≥18 years old; ② Gastric cancer is confirmed through gastroscopy biopsy; ③ The patient meets the relevant diagnostic criteria in People's Republic of China (PRC) Health Industry Standards: Diagnostic Criteria for Gastric Cancer, and has reached the level of stage III and IV futures, and the patient refuses to receive surgical treatment; ④ Estimated survival time \\> 3 months; ⑤ Without any chemotherapy treatment or more than one month from the end of the last chemotherapy course; ⑥Karnofsky functional status score ≥ 60;\n2. Exclusion criteria: ① patients who had allergic reaction to therapeutic drugs; ② patients with other types of cancer; ③ Patients with severe diseases of heart, liver, kidney, etc.; (4) gastrointestinal dysfunction or unable to oral medication.\n3. Shedding\u002Feliminating criteria: exiting in the midway; Lost to follow-up during the follow-up period; Treatment was not continued according to the treatment protocol.","ALL","18 Years",{"count":72,"type":73},40,"ESTIMATED","INTERVENTIONAL",[76],"NA","Chemotherapy is generally needed for advanced gastric cancer, and cisplatin is the main chemotherapy drug. However, there are many adverse reactions, including bone marrow suppression, gastrointestinal reactions, renal toxicity and neurotoxicity. These adverse reactions can affect the comfort and compliance of patients during treatment. At present, it is necessary to reduce adverse reactions of cisplatin and increase the chemotherapy sensitivity of gastric cancer to cisplatin. Recent studies have found that disulfiram has a potential anti-tumor effect. The disulfiram has shown significant in vivo and in vitro anti-tumor activity in preclinical studies, and has become a potential candidate drug for tumor treatment as an adjuvant in various clinical trials. In this clinical study, cisplatin combined with disulfiram is mainly used to treat advanced gastric cancer.",[79],"Chemotherapy；Advanced Gastric Cancer；Cisplatin；Disulfiram","NOT_YET_RECRUITING","2022-12-26",{"date":83,"type":84},"2022-12-28","ACTUAL",{"date":86,"type":73},"2023-06-01",{"date":88,"type":73},"2026-06-30",{"name":5,"class":6},1]