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Should patients in the conservative management arm develop hemorrhage or infarction related to their AVM, they then potentially become candidates for interventional therapy.",null,[22,27,32],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":20},"PROCEDURE","Neurosurgery","Surgical resection to be used when the lesion is considered by a multidisciplinary team to be safely 'operable'.",[9],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":20},"RADIATION","Radiation therapy","when the AVM is smaller than 3 cm, and considered to not be safely 'operable'.",[9],{"type":23,"name":33,"description":34,"armGroupLabels":35,"otherNames":20},"Embolization","Curative embolization, when the lesion is considered curable by embolization.",[9],[37],{"name":38,"affiliation":39,"role":40},"Daniel Roy, 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Center","Boston","Massachusetts","02118",{"type":60,"coordinates":75},[76,77],-71.05977,42.35843,{"lat":77,"lon":76},[80],{"name":81,"role":43,"phone":20,"phoneExt":20,"email":82},"Thanh Nguyen, MD","Thanh.Nguyen@bmc.org",{"facility":84,"status":54,"city":85,"state":86,"zip":87,"country":57,"countryCode":58,"cosmosGeoPoint":88,"geoPoint":92,"contacts":93},"University of New Mexico Health Sciences Center","Albuquerque","New Mexico","87131",{"type":60,"coordinates":89},[90,91],-106.65114,35.08449,{"lat":91,"lon":90},[94],{"name":95,"role":43,"phone":20,"phoneExt":20,"email":96},"Andrew Carlson, MD","AndrewCarlson@salud.unm.edu",{"facility":98,"status":54,"city":99,"state":20,"zip":20,"country":100,"countryCode":101,"cosmosGeoPoint":102,"geoPoint":106,"contacts":107},"Hospital Geral de Fortaleza","Fortaleza","Brazil","BR",{"type":60,"coordinates":103},[104,105],-38.54306,-3.71722,{"lat":105,"lon":104},[108,111],{"name":109,"role":43,"phone":20,"phoneExt":20,"email":110},"Iuri Martins, 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PhD",{"name":140,"role":40,"phone":20,"phoneExt":20,"email":20},{"facility":143,"status":54,"city":144,"state":145,"zip":146,"country":131,"countryCode":132,"cosmosGeoPoint":147,"geoPoint":151,"contacts":152},"Klink, Ruby","Montreal","Quebec","H2L 4M1",{"type":60,"coordinates":148},[149,150],-73.58781,45.50884,{"lat":150,"lon":149},[153,157,158,159,162,164,166,168,170,172,174],{"name":154,"role":43,"phone":155,"phoneExt":45,"email":156},"Ruby Klink, PhD","5148908000","ruby.klink.chum@ssss.gouv.qc.ca",{"name":154,"role":43,"phone":44,"phoneExt":45,"email":156},{"name":38,"role":40,"phone":20,"phoneExt":20,"email":20},{"name":160,"role":161,"phone":20,"phoneExt":20,"email":20},"Alain Weill, MD","SUB_INVESTIGATOR",{"name":163,"role":161,"phone":20,"phoneExt":20,"email":20},"Michel Bojanowski, MD",{"name":165,"role":161,"phone":20,"phoneExt":20,"email":20},"Chiraz Chaalala, MD",{"name":167,"role":161,"phone":20,"phoneExt":20,"email":20},"Jean-Paul Bahary, 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Asenjo","Santiago","Chile","CL",{"type":60,"coordinates":182},[183,184],-70.64827,-33.45694,{"lat":184,"lon":183},[187,190],{"name":188,"role":43,"phone":20,"phoneExt":20,"email":189},"Rodrigo Rivera Miranda, MD","rodrigorivera@me.com",{"name":188,"role":40,"phone":20,"phoneExt":20,"email":20},{"facility":192,"status":54,"city":193,"state":20,"zip":20,"country":194,"countryCode":195,"cosmosGeoPoint":196,"geoPoint":200,"contacts":201},"Universidad Autonoma de Bucaramanga","Bucaramanga","Colombia","CO",{"type":60,"coordinates":197},[198,199],-73.11895,7.125,{"lat":199,"lon":198},[202,205],{"name":203,"role":43,"phone":20,"phoneExt":20,"email":204},"Daniel Eduardo Mantilla Garcia, MD","dmantilla528@unab.edu.co",{"name":206,"role":43,"phone":20,"phoneExt":20,"email":207},"Andres Felipe Ortiz Giraldo, MD","aortiz131@unab.edu.co",{"facility":209,"status":54,"city":210,"state":211,"zip":212,"country":213,"countryCode":214,"cosmosGeoPoint":215,"geoPoint":219,"contacts":220},"CHRU de Brest (Brest University Hospital)","Brest","Brittany Region","29609","France","FR",{"type":60,"coordinates":216},[217,218],-4.48628,48.39029,{"lat":218,"lon":217},[221,224,225],{"name":222,"role":43,"phone":20,"phoneExt":20,"email":223},"Elsa Magro, MD","elsa.magro@chu-brest.fr",{"name":222,"role":40,"phone":20,"phoneExt":20,"email":20},{"name":226,"role":40,"phone":20,"phoneExt":20,"email":20},"Jean-Christophe Gentric, MD",{"facility":228,"status":54,"city":229,"state":20,"zip":230,"country":213,"countryCode":214,"cosmosGeoPoint":231,"geoPoint":235,"contacts":236},"Centre Hospit Régional Universitaire de Besançon","Besançon","25030",{"type":60,"coordinates":232},[233,234],6.01815,47.24878,{"lat":234,"lon":233},[237],{"name":238,"role":43,"phone":20,"phoneExt":20,"email":239},"Alessandra Biondi, MD","biondi.alessandra@gmail.com",{"facility":241,"status":54,"city":242,"state":20,"zip":243,"country":213,"countryCode":214,"cosmosGeoPoint":244,"geoPoint":248,"contacts":249},"Centre Hospitalier 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Nancy","Nancy","54035",{"type":60,"coordinates":360},[361,362],6.18496,48.68439,{"lat":362,"lon":361},[365],{"name":366,"role":43,"phone":20,"phoneExt":20,"email":367},"Serge Bracard, MD","s.bracard@chru-nancy.fr",{"facility":369,"status":54,"city":370,"state":20,"zip":371,"country":213,"countryCode":214,"cosmosGeoPoint":372,"geoPoint":376,"contacts":377},"Centre Hospitalier Universitaire de Nantes","Nantes","44093",{"type":60,"coordinates":373},[374,375],-1.55336,47.21725,{"lat":375,"lon":374},[378],{"name":379,"role":43,"phone":20,"phoneExt":20,"email":380},"Hubert Desal, MD","hubert.desal@chu-nantes.fr",{"facility":382,"status":54,"city":383,"state":20,"zip":384,"country":213,"countryCode":214,"cosmosGeoPoint":385,"geoPoint":389,"contacts":390},"Hôpital Universitaire Pitié-Salpêtrière","Paris","75013",{"type":60,"coordinates":386},[387,388],2.3488,48.85341,{"lat":388,"lon":387},[391],{"name":392,"role":43,"phone":20,"phoneExt":20,"email":393},"Philippe Cornu, 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Strasbourg","Strasbourg","67200",{"type":60,"coordinates":445},[446,447],7.74553,48.58392,{"lat":447,"lon":446},[450],{"name":451,"role":43,"phone":20,"phoneExt":20,"email":452},"François Proust, MD","francois.proust@neurochirurgie.fr",{"facility":454,"status":54,"city":455,"state":20,"zip":456,"country":213,"countryCode":214,"cosmosGeoPoint":457,"geoPoint":461,"contacts":462},"Centre Hospitalier Universitaire de Toulouse","Toulouse","70034",{"type":60,"coordinates":458},[459,460],1.44367,43.60426,{"lat":460,"lon":459},[463],{"name":464,"role":43,"phone":20,"phoneExt":20,"email":465},"Christophe Cognard, MD","cognard.c@chu-toulouse.fr",{"facility":467,"status":54,"city":468,"state":20,"zip":469,"country":213,"countryCode":214,"cosmosGeoPoint":470,"geoPoint":474,"contacts":475},"Centre Hospitalier Régional Universitaire de Tours","Tours","37000",{"type":60,"coordinates":471},[472,473],0.70398,47.39484,{"lat":473,"lon":472},[476],{"name":477,"role":43,"phone":20,"phoneExt":20,"email":478},"Denis Herbreteau, MD","denis.herbreteau@univ-tours.fr",{"type":480,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR",[482],{"name":483,"class":6},"Centre Hospitalier Régional et Universitaire de Brest","100216702","treatment-of-brain-avms-tobas-study-100216702",false,"NCT02098252","Treatment of Brain AVMs (TOBAS) Study","Treatment of Brain AVMs (TOBAS) Study: A Randomized Controlled Trial and Registry","TOBAS","Inclusion Criteria:\n\n* Any patient with a brain AVM\n\nExclusion Criteria:\n\n* Hemorrhagic presentation with mass effect requiring surgical management. In these cases, if a residual AVM is found after the initial surgery, the patient could then be a candidate for TOBAS.","ALL","5 Years",{"count":495,"type":496},1000,"ESTIMATED","INTERVENTIONAL",[499],"NA","The objectives of this study and registry are to offer the best management possible for patients with brain arteriovenous malformations (AVMs) (ruptured or unruptured) in terms of long-term outcomes, despite the presence of uncertainty. Management may include interventional therapy (with endovascular procedures, neurosurgery, or radiotherapy, alone or in combination) or conservative management.\n\nThe trial has been designed to test a) whether medical management or interventional therapy will reduce the risk of death or debilitating stroke (due to hemorrhage or infarction) by an absolute magnitude of about 15% (over 10 years) for unruptured AVMs (from 30% to 15%); and, b) to test if endovascular treatment can improve the safety and efficacy of surgery or radiation therapy by at least 10% (80% to 90%).\n\nAs for the nested trial on the role of embolization in the treatment of Brain AVMs by other means: the pre-surgical or pre-radiosurgery embolization of cerebral AVMs can decrease the number of treatment failures from 20% to 10%. In addition,embolization of cerebral AVMs can be accomplished with an acceptable risk, defined as permanent disabling neurological complications of 8%.",[502,503,504,505,506],"Unruptured Brain Arteriovenous Malformation","Ruptured Brain Arteriovenous Malformation","Arteriovenous Malformations","AVM","BAVM",[508,504,505,506,509,510,511,512,513,514,515,516],"brain arteriovenous malformation","Stroke","Intracranial Hemorrhage","Congenital Abnormalities","Aneurysm","Vascular Malformations","Cardiovascular Abnormalities","Cardiovascular Diseases","Vascular Diseases","2024-08-13",{"date":519,"type":520},"2024-08-15","ACTUAL",{"date":522,"type":20},"2014-05",{"date":524,"type":496},"2036-01",{"name":5,"class":6},30]