[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100553647":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":40,"responsibleParty":55,"collaborators":58,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":25,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":25,"enrollmentInfo":71,"targetDuration":25,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":43,"whyStopped":25,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Shanghai 10th People's Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Olfactory Enrichment Group","EXPERIMENTAL","All participants enrolled in the olfactory enrichment group will receive twice sessions per day with an interval of at least 6 hours on preoperative day 1 and postoperative day 1-3. Each session will last 30 minutes. Each participant will be equipped with an electrical odor dispenser which allowed to distribute 8 odors (grapefruit, lavender, lemon, peppermint, tangerine, green tea, cloves and eucalyptus). When pushing a button, 4 odors will be released in turn and participants will sniff each odor (approximately 4 ml odorized air) for approximately 30 seconds by a nasal catheter. Considering of the adaption of odors, 4 odors will be used in the morning session and another 4 odors will be used in the afternoon session.",[13],"Other: Olfactory Enrichment",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham Group","SHAM_COMPARATOR","The sham group will receive sham olfactory enrichment sessions, which is designed with the same pattern (twice a day, 30 min for each session, on preoperative day 1 and on postoperative day 1-3. However, the containers provided to the sham group will be odorless. The odor containers and labels will appear identical to those used in the olfactory enrichment group.",[19],"Other: Sham",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Olfactory Enrichment","Each participant will be equipped with an electrical odor dispenser which allowed to distribute 8 odors (grapefruit, lavender, lemon, peppermint, menthol, tangerine, green tea, and bergamot). The choice of odors was guided by (1) pleasantness of the odors, (2) presence of slight trigeminal activation in some of the odors, e.g., peppermint, (3) evaporation characteristics, so that the odors would last for the duration of the experiment, (4) technical issues mostly in terms of compatibility with the odor cartridge, (5) availability, and (6) inspiration from the previous studies.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Sham","The containers provided to the sham group will be odorless. The odor containers and labels will appear identical to those used in the olfactory enrichment group.",[15],[31],{"name":32,"affiliation":33,"role":34},"Yuan Shen","Shanghai Mental Health Center","PRINCIPAL_INVESTIGATOR",[36],{"name":32,"role":37,"phone":38,"phoneExt":25,"email":39},"CONTACT","+8618602169932","dr.yuanshen@foxmail.com",[41],{"facility":42,"status":43,"city":44,"state":25,"zip":25,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Shanghai Tenth People's Hospital","RECRUITING","Shanghai","China","CN",{"type":48,"coordinates":49},"Point",[50,51],121.45806,31.22222,{"lat":51,"lon":50},[54],{"name":32,"role":37,"phone":25,"phoneExt":25,"email":25},{"type":34,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Yuan Shen, MD, PhD","Director",[59],{"name":60,"class":61},"National Natural Science Foundation of China","OTHER_GOV","100553647","treatment-of-perioperative-neurocognitive-disorders-with-olfactory-enrichment-100553647",false,"NCT06488807","Treatment of Perioperative Neurocognitive Disorders With Olfactory Enrichment","Treatment of Perioperative Neurocognitive Disorders With Olfactory Enrichment: Study Protocol for a Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age ≥65 years old.\n2. Having a scheduled surgery (≥2 hours, general anesthesia) (e.g., total hip replacement, toal knee replacement, open reduction and internal fixation of hip and lumbar spine).\n3. Being able to complete neuropsychological tests, 3D-CAM and CAM-S.\n4. Chinese Mandarin as their native language.\n5. Edmonton frailty scale (EFS) score ≥ 6.\n\nExclusion Criteria:\n\n1. Having delirium, assessed by 3D-CAM, before surgery.\n2. Having a brain tumour, stroke or mental disorders (eg, major depressive disorder or dementia).\n3. Participating in other clinical studies at the time of screening.\n4. Unwillingness to comply with the protocol or procedures.","ALL","65 Years",{"count":72,"type":73},686,"ESTIMATED","INTERVENTIONAL",[76],"NA","Perioperative neurocognitive disorder (PND) is one of the most common postoperative complications among elderly patients. However, the mechanism and targeted intervention of PND remains unclear. Our previous clinical studies demonstrated the association between olfactory impairment and PND. Moreover, our translational studies showed that anesthesia\u002Fsurgery induced olfactory impairment and caused cognitive impairment in mice and olfactory enrichment could prevent the anesthesia\u002Fsurgery-induced cognitive impairment. However, there was no clinical investigation to determine whether olfactory enrichment can mitigate PND in elderly patients. Therefore, we propose determining whether olfactory enrichment can prevent and\u002For treat PND in elderly patients.",[79],"Perioperative Neurocognitive Disorder",[79,81],"Odor Enrichment","2025-05-13",{"date":84,"type":85},"2025-05-14","ACTUAL",{"date":87,"type":85},"2025-04-07",{"date":89,"type":73},"2028-12-31",{"name":5,"class":6},1]