[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100619535":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":55,"locations":61,"responsibleParty":73,"collaborators":75,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":26,"eligibilityCriteria":83,"healthyVolunteers":79,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":26,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":98,"overallStatus":100,"whyStopped":26,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"University of California, Los Angeles","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"LO-RUTF","EXPERIMENTAL","Participants in the LO-RUTF arm will receive approximately 190 kcal\u002Fkg\u002Fday of Lipid-Optimized Ready to Use Therapeutic Food (RUTF). This RUTF is locally produced and contains maize, milk powder, rice flour, soymeal, sugar, whey isolate, palm oil, flaxseed oil, coconut oil, premix and an emulsifier.",[13],"Dietary Supplement: Lipid-Optimized Ready to Use Therapeutic Food (RUTF)",{"label":15,"type":16,"description":17,"interventionNames":18},"RUTF","ACTIVE_COMPARATOR","Participants in the RUTF arm will receive approximately 190 kcal\u002Fkg\u002Fday of Ready to Use Therapeutic Food (RUTF). This RUTF produced by UNICEF contains peanut paste, sugar, non-fat dried milk, vegetable oil, a premix containing concentrated minerals and vitamins, and an emulsifier.",[19],"Dietary Supplement: Ready to Use Therapeutic Food (RUTF)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Lipid-Optimized Ready to Use Therapeutic Food (RUTF)","Since this is a pilot trial for the study recipe, we have increased the vitamin D3 content in this RUTF as an experimental variable within this study.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Ready to Use Therapeutic Food (RUTF)","This is the standard of care RUTF with UNICEF product specifications. This RUTF will be produced internationally and shipped to Pakistan.",[15],[32,33],"UNICEF RUTF","Standard RUTF",[35,38,42,45,47,49,51,53],{"name":36,"affiliation":5,"role":37},"Kiran K Masood, MD","PRINCIPAL_INVESTIGATOR",{"name":39,"affiliation":40,"role":41},"Mohid Khan","The Satya Nutrition Foundation","STUDY_DIRECTOR",{"name":43,"affiliation":40,"role":44},"Samir Ismail","STUDY_CHAIR",{"name":46,"affiliation":40,"role":44},"Akhila Annadanam",{"name":48,"affiliation":40,"role":44},"Tu Nguyen",{"name":50,"affiliation":40,"role":44},"Fatima Ahmad",{"name":52,"affiliation":40,"role":44},"Meghana Dantuluri",{"name":54,"affiliation":40,"role":41},"Amith Umesh",[56],{"name":57,"role":58,"phone":59,"phoneExt":26,"email":60},"Ahmed Moutwakil","CONTACT","4244853200","amoutwakil@mednet.ucla.edu",[62],{"facility":63,"status":26,"city":64,"state":26,"zip":26,"country":65,"countryCode":66,"cosmosGeoPoint":67,"geoPoint":72,"contacts":26},"Aga Khan University","Karachi","Pakistan","PK",{"type":68,"coordinates":69},"Point",[70,71],67.0104,24.8608,{"lat":71,"lon":70},{"type":37,"investigatorFullName":57,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Co-Investigator",[76],{"name":63,"class":6},"100619535","treatment-of-severe-acute-malnutrition-in-children-6-to-59-months-old-with-standard-ready-to-use-therapeutic-food-compared-to-a-newly-formulated-lipid-optimized-ready-to-use-therapeutic-food-100619535",false,"NCT07345884","Treatment of Severe Acute Malnutrition in Children 6 to 59 Months Old With Standard Ready To Use Therapeutic Food Compared to a Newly Formulated Lipid Optimized Ready To Use Therapeutic Food","Comparison of Treatment of Severe Acute Malnutrition in Children 6 to 59 Months Old With Standard Ready To Use Therapeutic Food and Newly Formulated Lipid Optimized Ready To Use Therapeutic Food an Individual Randomized Double Blind Controlled Trial","Inclusion Criteria:\n\n* Children aged 6-59 months with severe acute malnutrition, i.e., MUAC \\\u003C11.5 cm, and\u002For weight-for-height\u002Flength z-score \\\u003C -3, and\u002For with bilateral pitting edema, with an appetite to completely consume a 30 g test feeding, and without medical complications presenting at selected rural therapeutic feeding health facilities\n\nExclusion Criteria:\n\n* Children that are simultaneously involved in another research trial or supplemental feeding program, are developmentally delayed, have vision or hearing deficits, or have a history of milk or peanut allergy.\n* Chronic diseases such as malabsorption, chronic kidney disease, inflammatory bowel disease, congenital heart disease, endocrine disorders (e.g., hypothyroidism, growth hormone deficiencies), recurrent infections (e.g., pneumonia, cough, fever, pharyngitis), chronic respiratory diseases (e.g., asthma, lung diseases), congenital or acquired immunodeficiency, and neurological disorders","ALL","6 Months","59 Months",{"count":88,"type":89},125,"ESTIMATED","INTERVENTIONAL",[92],"NA","The goal of this randomized clinical trial is to learn if a newly formulated Lipid-Optimized Ready-to-Use Therapeutic Food (LO-RUTF) can treat severe acute malnutrition in children aged 6 to 59 months. The main questions it aims to answer are:\n\n1. Does LO-RUTF impact physical recovery from severe acute malnutrition in participants?\n2. Does LO-RUTF impact neurocognitive performance after 8 and 12 weeks of treatment?\n\nResearchers will compare LO-RUTF to standard RUTF see if our energy-dense food compares to standard issue RUTF in terms of promoting recovery from severe acute malnutrition.\n\nParticipants will\n\n* Take a one-week ration of LO-RUTF or standard RUTF based on the participant's weight\n* Return every week for checkups, tests and to receive the next ration of assigned RUTF if eligible\n* Be assessed for neurocognitive function through Malawi Developmental Assessment Tool (MDAT) at three time points (before treatment, 4 weeks, 12 weeks)",[95,96,97],"Severe Acute Malnutrition in Childhood","Malnutrition, Child","Neurocognition, Child",[15,99],"Ready-to-use therapeutic food","NOT_YET_RECRUITING","2026-04-20",{"date":103,"type":104},"2026-04-22","ACTUAL",{"date":106,"type":89},"2026-06",{"date":108,"type":89},"2026-10",{"name":5,"class":6},1]