[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100355886":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":10,"centralContacts":36,"locations":46,"responsibleParty":66,"collaborators":10,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":10,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":10,"maxAge":10,"enrollmentInfo":78,"targetDuration":10,"studyType":81,"phases":10,"briefSummary":82,"conditions":83,"keywords":10,"overallStatus":49,"whyStopped":10,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Chinese University of Hong Kong","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"substance abuse group",null,"Patients with voiding dysfunction secondary to substance abuse in a special clinic",[13,14,15,16],"Drug: First line treatment: oral NSAID and anticholinergic agents","Drug: Second line treatment: additional treatment for pain control","Drug: Third line treatment: A course of intravesical hyaluronate will be given.","Procedure: Fourth line treatment: surgical intervention",[18,23,27,31],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"DRUG","First line treatment: oral NSAID and anticholinergic agents","oral NSAID and anticholinergic agents",[9],{"type":19,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"Second line treatment: additional treatment for pain control","Gabapentin, tramadol, Lyrica",[9],{"type":19,"name":28,"description":29,"armGroupLabels":30,"otherNames":10},"Third line treatment: A course of intravesical hyaluronate will be given.","A course of intravesical hyaluronate will be given.",[9],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":10},"PROCEDURE","Fourth line treatment: surgical intervention","Consideration of hydrodistention and augmentation cystoplasty",[9],[37,42],{"name":38,"role":39,"phone":40,"phoneExt":10,"email":41},"Chi Fai Ng, MD","CONTACT","852-3505-2625","ngcf@surgery.cuhk.edu.hk",{"name":43,"role":39,"phone":44,"phoneExt":10,"email":45},"Pui Tak Lai, BN","852-3505-1663","francolai@surgery.cuhk.edu.hk",[47],{"facility":48,"status":49,"city":50,"state":10,"zip":10,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Prince of Wales Hospital","RECRUITING","Shatin","Hong Kong","HK",{"type":54,"coordinates":55},"Point",[56,57],114.18333,22.38333,{"lat":57,"lon":56},[60,63],{"name":61,"role":39,"phone":62,"phoneExt":10,"email":41},"Chi Fai NG, MD","3505 3953",{"name":64,"role":39,"phone":65,"phoneExt":10,"email":45},"Pui Tak LAI, BN","3505 1663",{"type":67,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","NG Chi Fai","Principal Investigator","100355886","treatment-outcomes-under-a-standardized-treatment-protocol-in-patients-suffered-substance-abuse-related-voiding-dysfunction-100355886",false,"NCT03913819","Treatment Outcomes Under a Standardized Treatment Protocol in Patients Suffered Substance Abuse Related Voiding Dysfunction","Prospective Longitudinal Study on the Treatment Outcomes of Various Treatment Modalities Under a Standardized Treatment Protocol in Patients Suffered Substance Abuse Related Voiding Dysfunction","Inclusion Criteria:\n\n* Patients suffered substance abuse induced voiding dysfunction\n\nExclusion Criteria:\n\n* Patient not agreed for consent\n* Patient that will not comply to our treatment protocol","ALL",{"count":79,"type":80},1000,"ESTIMATED","OBSERVATIONAL","With the increase of substance abuse over the world, substance abuse e.g. ketamine and methamphetamine related voiding dysfunction is becoming an important medical problem. However, while the clinical manifestation of the condition is becoming better defined, the underlying pathophysiology is still poorly understood. Moreover, majority of the current treatment is just based on the experience on some small case series and there is no treatment data for larger patient sample or standard recommended treatment in the literature. In order to improve the management of this condition, investigators have formulated a treatment protocol based on the current literatures on the management of voiding dysfunction and also a similar condition, interstitial cystitis \u002F painful-bladder syndrome (IC\u002FPBS). The protocol basically consists of the following modalities:\n\n* Basic information and education on the condition, principle of treatment and psychosocial support.\n* First line treatment will include a course of oral anti-inflammatory drugs (for the control of the inflammation process and pain) and anticholinergic agents (for the irritative urinary symptoms).\n* If these simple oral medication are found to be not effective, then further treatment will include other oral medications, such as amitriptyline and gabapentin, and some drugs that directly applied into the bladder cavity (hyaluronate) or bladder muscle (botulinum toxin).\n* For those patients with intractable symptoms and failed all the above treatments, surgical treatment (hydrodistension, augmentation cystoplasty) will be discussed.\n\nThe purpose of this research is to assess the effectiveness of the above treatment protocol in the management of substance induced voiding dysfunction and also assess any possible adverse events related to the usage of the drugs.",[84,85],"Voiding Dysfunction","Substance Abuse","2025-05-04",{"date":88,"type":89},"2025-05-06","ACTUAL",{"date":91,"type":89},"2011-12-10",{"date":93,"type":80},"2026-12-31",{"name":5,"class":6},1]