[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100449762":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":33,"locations":38,"responsibleParty":69,"collaborators":72,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":78,"sex":83,"minAge":84,"maxAge":24,"enrollmentInfo":85,"targetDuration":24,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":96,"overallStatus":41,"whyStopped":24,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"Florida International University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Cognitive-Behavioral Therapy for Adherence and Depression (CBT-AD)","EXPERIMENTAL","Participants randomized to receive CBT-AD immediately will complete up to 15 individual sessions (12 session with 3 booster sessions) focused on depression and one session of ART Adherence counseling during the four months following randomization.",[13,14],"Behavioral: Cognitive-Behavioral Therapy for Adherence and Depression (CBT-AD)","Behavioral: Antiretroviral Therapy (ART) Adherence Counseling",{"label":16,"type":10,"description":17,"interventionNames":18},"Wait-List Control (WLC)","Participants randomized to the WLC condition will receive one session of ART adherence counseling immediately following randomization. After six months, WLC participants will have the opportunity to receive 15 individually delivered CBT-AD sessions (12 sessions and 3 booster sessions) focused on depression.",[13,14],[20,25],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"BEHAVIORAL","CBT-AD is a behavioral intervention administered either in person or via Zoom. Each session lasts approximately 50 minutes. Participants will receive up to 12 individually delivered sessions over 4 months. Participants receive up to three individually delivered booster sessions through 6 months.",[9,16],null,{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Antiretroviral Therapy (ART) Adherence Counseling","This treatment involves a single session integrating CBT for depression with CBT for adherence following our \"Life-Steps\" approach.",[9,16],[30],{"name":31,"affiliation":5,"role":32},"Adam W Carrico, PhD","PRINCIPAL_INVESTIGATOR",[34],{"name":31,"role":35,"phone":36,"phoneExt":24,"email":37},"CONTACT","(305) 348-7887","acarrico@fiu.edu",[39,58],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"University of Miami Neuroimaging Facility","RECRUITING","Coral Gables","Florida","33146","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-80.26838,25.72149,{"lat":51,"lon":50},[54],{"name":55,"role":35,"phone":56,"phoneExt":24,"email":57},"Roger McIntosh, PhD","305-243-2047","r.mcintosh@miami.edu",{"facility":59,"status":41,"city":60,"state":43,"zip":61,"country":45,"countryCode":46,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"Care Resource - Midtown Miami","Miami","33137",{"type":48,"coordinates":63},[64,65],-80.19366,25.77427,{"lat":65,"lon":64},[68],{"name":31,"role":35,"phone":36,"phoneExt":24,"email":37},{"type":32,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Adam Carrico, PhD","Professor",[73],{"name":74,"class":75},"National Institute of Mental Health (NIMH)","NIH","100449762","treatment-research-investigating-depression-effects-on-neuroimmune-targets-trident-100449762",false,"NCT05136703","Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)","TRIDENT","Inclusion Criteria:\n\n1. Age 18 or older\n2. Speaks and reads English\n3. Verified HIV+ status with antiretroviral medications bearing his\u002Fher name\n4. Current diagnosis on Major Depressive Disorder (MDD) using a structured clinical interview (DIAMOND) or Hamilton Rating Scale for Depression scores of 7 or greater\n5. If prescribed antidepressants, on a stable regimen and dose for at least 2 months\n6. Suppressed HIV viral load (\\\u003C 200 copies\u002FmL)\n7. Able to complete Functional Magnetic Resonance Imaging (fMRI) scans (i.e., no claustrophobia, no metal implants, no pacemaker, and BMI \\\u003C 40)\n\nExclusion Criteria:\n\n1. Unable to provide informed consent\n2. Active, untreated major mental illness\n3. Pregnancy at baseline\n4. Received CBT for depression in the past 2 years\n5. 5\\. Otherwise eligible but does not complete the run-in period that includes the baseline assessment, biospecimen collection, the fMRI visit, and a separately scheduled randomization visit","ALL","18 Years",{"count":86,"type":87},150,"ESTIMATED","INTERVENTIONAL",[90],"NA","The purpose of this randomized controlled trial is to understand how a cognitive-behavioral treatment (a form of psychological treatment) for depression changes the gut microbiome (micro-organisms that regulate the health of the gut), immune system, and the brain functioning in people living with HIV.",[93,94,95],"Depression","HIV-1-infection","Inflammation",[93,97,98,99,100,101],"Microbiome","HIV","CBT-AD","Gut","Brain","2026-02-04",{"date":104,"type":105},"2026-02-06","ACTUAL",{"date":107,"type":105},"2022-08-30",{"date":109,"type":87},"2027-12-31",{"name":5,"class":6},2]