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The patient must be diagnosed with non-psychotic unipolar Major Depressive Disorder.\n2. The patient must be in a major depressive episode for ≥12 months or have had at least 3 lifetime depressive episodes.\n3. The patient has tried and failed a minimum of four different types of antidepressant treatments as measured by a tool designed for this purpose.\n4. Depression medication and treatment regimen must be stable for a minimum of 4 weeks before the first baseline visit\n\nExclusion Criteria:\n\n1. Pregnant or those who plan to become pregnant during study\n2. Presence of other anatomic or comorbid conditions, or other medical, social, or psychological conditions that could limit participation in the study or interfere with adherence to the study protocol.\n3. Current or lifetime history of psychotic features in any Major Depressive Episode.\n4. 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