[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100516907":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":23,"locations":24,"responsibleParty":44,"collaborators":23,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":23,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":56,"maxAge":23,"enrollmentInfo":57,"targetDuration":23,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":23,"overallStatus":27,"whyStopped":23,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"General Hospital of Shenyang Military Region","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Head-down position","EXPERIMENTAL","head-down position as an adjunct to guideline-based treatment",[13],"Other: head-down position",{"label":15,"type":6,"description":16,"interventionNames":17},"control","guideline-based treatment",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"head-down position","-20° Trendelenburg as an adjunct to guideline-based treatment,",[9,15],null,[25],{"facility":26,"status":27,"city":28,"state":23,"zip":29,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Department of Neurology, General Hospital of Northern Theater Command","RECRUITING","Shenyang","110016","China","CN",{"type":33,"coordinates":34},"Point",[35,36],123.43278,41.79222,{"lat":36,"lon":35},[39],{"name":40,"role":41,"phone":42,"phoneExt":23,"email":43},"Hui-Sheng Chen, Ph.D.","CONTACT","+86 13352452086","chszh@aliyun.com",{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"PRINCIPAL_INVESTIGATOR","Hui-Sheng Chen","Director","100516907","trendelenburg-position-for-acute-anterior-circulation-ischemic-stroke-with-large-artery-atherosclerosis-etiology-hopes-3-100516907",false,"NCT06010641","Trendelenburg Position for Acute Anterior Circulation Ischemic Stroke With Large Artery Atherosclerosis Etiology (HOPES 3)","Trendelenburg Position for Acute Anterior Circulation Ischemic Stroke With Large Artery Atherosclerosis Etiology (HOPES 3): a Prospective, Randomized, Open-label, Blinded-endpoint, Multi-center Trial","Inclusion Criteria:\n\n* Age ≥ 18 years old\n* Acute ischemic stroke confirmed by NCCT or MRI;\n* Moderate neurologic deficit (6≤ NIHSS ≤ 16) within 24 hours of onset, or progressing from mild (NIHSS ≤ 5) to moderate neurologic deficit (6≤ NIHSS ≤ 16) within 24 hours, requiring ≥ 4 point increase in NIHSS score although the onset time is beyond 24 hours;\n* Probable large artery atherosclerosis etiology based on the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria (responsible artery stenosis ≥ 50% or occlusion);\n* Anterior circulation stroke (internal carotid artery, M1 or M2 of middle cerebral artery);\n* First stroke onset or past stroke without obvious neurological deficit (mRS≤2);\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Pre-stroke disability (mRS≥3);\n* Patients with disturbance of consciousness;\n* Patients who plan to undergo or have completed thrombolysis or mechanical thrombectomy;\n* Hemorrhagic stroke or combined ischemic and hemorrhagic stroke;\n* Serious comorbidity, such as liver or kidney insufficiency, malignant tumor, etc;\n* Other stroke etiologies, such as cardiogenic embolism, arteritis, arterial dissection, moyamoya disease, etc;\n* Previous history of intracerebral hemorrhage within 1 year;\n* Any contraindication to head-down position (e.g. active vomiting, pneumonia, uncontrolled heart failure);\n* Planned carotid or intracranial revascularization within 3 months;\n* Severe uncontrolled hypertension (systolic blood pressure over 180mmHg or diastolic blood pressure over 100 mmHg);\n* Cardiac insufficiency (NYHA Class ≥II);\n* Pregnant or lactating women;\n* Comorbidity with other serious diseases;\n* Participating in other clinical trials within 3 months;\n* Patients not suitable for the study considered by researcher.","ALL","18 Years",{"count":58,"type":59},600,"ESTIMATED","INTERVENTIONAL",[62],"NA","The effect of head position as a nonpharmacological therapy on acute ischemic stroke (AIS) remains inconclusive. Recent HOPES2 (Head dOwn-Position for acutE moderate ischemic Stroke with large artery atherosclerosis) suggest the safety, feasibility, and potential benefit of the head-down position (HDP) in acute ischemic stroke. The current study aims to investigate the efficacy and safety of HDP in acute moderate ischemic stroke patients with large artery atherosclerosis.",[65],"Stroke, Acute Ischemic","2026-04-22",{"date":68,"type":69},"2026-04-27","ACTUAL",{"date":71,"type":69},"2024-01-10",{"date":73,"type":59},"2027-10-30",{"name":5,"class":6},1]