[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623522":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":26,"centralContacts":35,"locations":45,"responsibleParty":68,"collaborators":10,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":10,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":10,"studyType":86,"phases":10,"briefSummary":87,"conditions":88,"keywords":10,"overallStatus":48,"whyStopped":10,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"South Valley University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A : (Systemic Lupus Erythrematosus)",null,"About 60 patients ) diagnosed with SLE based on 2019 EULAR\u002FACR criteria, each with at least one cutaneous manifestation.",[13],"Diagnostic Test: TREX1 gene polymorphisms",{"label":15,"type":10,"description":16,"interventionNames":17},"Group B (Healthy Controls)","30 age- and sex-matched healthy controls with no personal or family history of autoimmune disease and negative ANA and anti-dsDNA.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DIAGNOSTIC_TEST","TREX1 gene polymorphisms","To assess the prevalence of selected autoantibodies as (anti-dsDNA, anti-Sm, anti-Ro\u002FSSA, anti-La\u002FSSB) and TREX1 gene polymorphisms in SLE patients, and their association with clinical features and disease activity",[9,15],[25],"anti-dsDNA, anti-Sm, anti-Ro\u002FSSA, anti-La\u002FSSB",[27,31],{"name":28,"affiliation":29,"role":30},"Eisa Mohammed Hegazy, Professor","Dermatology, Venereology and Andrology. Faculty of Medicine,Qena University","STUDY_CHAIR",{"name":32,"affiliation":33,"role":34},"Mohammed Hosny Hassan, Professor","Biochemistry ,Qena faculty of medicine ,south valley university","STUDY_DIRECTOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":10,"email":40},"Amira Rabea AbuElfadl, MSc","CONTACT","+201146299296","Amirarabea575@gmail.com",{"name":42,"role":38,"phone":43,"phoneExt":10,"email":44},"Soheir Abdel-hamid Ali, Lecturer","+201066877343","Soher.abdel-hamed@med.svu.edu.eg",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":10,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Qina University hospital, South Valley University Hospital","RECRUITING","Qina","South Valley","Egypt","EG",{"type":54,"coordinates":55},"Point",[56,57],32.72671,26.16418,{"lat":57,"lon":56},[60,64],{"name":61,"role":38,"phone":62,"phoneExt":10,"email":63},"Ebtehal Alaa El-din Kotp Mohammed, Lecturer","+201066798383","Ebtehal_alaa@med.svu.edu.eg",{"name":65,"role":38,"phone":66,"phoneExt":10,"email":67},"Shimaa Saber Ahmed, M.D","+201006393764","shimaasaber063@gmail.com",{"type":69,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Amira Rabea AbuElfadl","Resident at Dermatology , venereology and andrology, Faculty of medicine","100623522","trex1-gene-mutations-and-their-role-in-systemic-lupus-erythematosus-100623522",false,"NCT07397728","\" TREX1 Gene Mutations and Their Role in Systemic Lupus Erythematosus","TREX1 Gene Mutations and Their Role in Systemic Lupus Erythematosus: A Genotype-Phenotype Correlation Study","Inclusion Criteria:\n\n* Adult aged 18-60 years\n* Diagnosed as SLE per 2019 EULAR\u002FACR classification criteria.\n* Presence of at least one cutaneous manifestation (acute, subacute, or chronic).\n* Willing to provide written informed consent for participation and genetic testing\n\nExclusion Criteria:\n\n* Overlap autoimmune syndromes (e.g., dermatomyositis, systemic sclerosis).\n* Systemic infection, malignancy, or pregnancy.\n* Use of biologic therapy or immunosuppressive pulses within one month.",true,"ALL","18 Years","60 Years",{"count":84,"type":85},90,"ESTIMATED","OBSERVATIONAL","Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by diverse clinical manifestations, prominently involving the skin.",[89],"Systemic Lupus Erythematosus","2026-02-05",{"date":92,"type":93},"2026-02-09","ACTUAL",{"date":95,"type":93},"2025-06-10",{"date":97,"type":85},"2026-06-10",{"name":5,"class":6},1]