[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624503":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":41,"locations":51,"responsibleParty":69,"collaborators":71,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":46,"eligibilityCriteria":81,"healthyVolunteers":77,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":46,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":46,"overallStatus":54,"whyStopped":46,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Columbia University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Acceptance- and mindfulness-based exposure therapy (AMBET)","EXPERIMENTAL","Remotely delivered psychotherapy combining exposure therapy with mindfulness.",[13],"Behavioral: Acceptance and Mindfulness Based Exposure Therapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Present-Centered Therapy (PCT)","ACTIVE_COMPARATOR","Remotely delivered psychotherapy that focuses on increasing adaptive responses to current life stressors and difficulties.",[19],"Behavioral: Present-Centered Therapy",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Acceptance and Mindfulness Based Exposure Therapy","Eight sessions of exposure therapy combined with mindfulness delivered via videoconferencing platform. AMBET will consist of 90-minute weekly sessions for 4 weeks, then every other week for 4 more sessions.",[9],[27],"AMBET",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Present-Centered Therapy","Twelve 60-minute weekly sessions of psychotherapy delivered via videoconferencing platform.",[15],[33],"PCT",[35,38],{"name":36,"affiliation":5,"role":37},"Yuval Neria, PhD","PRINCIPAL_INVESTIGATOR",{"name":39,"affiliation":5,"role":40},"Maja Bergman, PhD","STUDY_DIRECTOR",[42,48],{"name":43,"role":44,"phone":45,"phoneExt":46,"email":47},"Yuval Neria, Ph.D.","CONTACT","212-543-6061",null,"ny126@cumc.columbia.edu",{"name":49,"role":44,"phone":45,"phoneExt":46,"email":50},"Maja Bergman, Ph.D.","mb3829@cumc.columbia.edu",[52],{"facility":53,"status":54,"city":55,"state":55,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"Columbia University Irving Medical Center","RECRUITING","New York","10032","United States","US",{"type":60,"coordinates":61},"Point",[62,63],-74.00597,40.71427,{"lat":63,"lon":62},[66,67],{"name":49,"role":44,"phone":46,"phoneExt":46,"email":50},{"name":68,"role":37,"phone":46,"phoneExt":46,"email":46},"Yuval Neria",{"type":37,"investigatorFullName":68,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":46,"oldOrganization":46},"Professor of Clinical Medical Psychology",[72],{"name":73,"class":74},"National Institute on Aging (NIA)","NIH","100624503","trial-of-acceptance-and-mindfulness-based-exposure-therapy-ambet-and-present-centered-therapy-pct-100624503",false,"NCT07410481","Trial of Acceptance and Mindfulness-based Exposure Therapy (AMBET) and Present Centered Therapy (PCT)","A Randomized Clinical Trial of Acceptance and Mindfulness-based Exposure Therapy (AMBET) and Present Centered Therapy (PCT)","Inclusion Criteria:\n\n1. Between 18 and 81 years old at the time of consent\n2. Fluency in English\n3. Medical history of cardiac arrest \\>3 months ago\n4. Clinically elevated PTSD symptoms (Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) score ≥25)\n5. U.S. Resident\n\nExclusion Criteria:\n\n1. Lifetime history of primary psychotic or bipolar disorders\n2. Current substance use disorder (moderate or severe in the past 6 months)\n3. Active suicidal ideation with some intent to act in past 12 months, and\u002For suicide attempt in past 24 months\n4. Substantial cognitive impairment (Mini Mental Status Exam (MMSE) score \\\u003C25)\n5. Initiation of new psychotropic medication \\\u003C3 months ago\n6. Non-cardiac etiology of CA (drowning, bleeding, trauma, drug overdose, etc)\n7. Terminal illness with life expectancy \\\u003C1 year\n8. Concurrent psychotherapy for PTSD","ALL","18 Years","81 Years",{"count":86,"type":87},90,"ESTIMATED","INTERVENTIONAL",[90],"NA","The goal of this clinical trial is to learn if a new therapy called Acceptance- and Mindfulness-Based Exposure Therapy (AMBET) helps treat post-traumatic stress disorder (PTSD) in people who survived a cardiac arrest. This study will compare AMBET to another psychotherapy treatment called Present Centered Therapy (PCT) to see which therapy is more effective in treating PTSD.\n\nThe main questions it aims to answer are:\n\nDoes AMBET reduce PTSD symptoms in survivors of cardiac arrest? How do the benefits of AMBET compare to PCT?\n\nParticipants will:\n\n* Be randomly assigned to receive either AMBET or PCT\n* Attend 12 hours of individual psychotherapy sessions over about 12 weeks\n* Complete short weekly surveys about their mood and behaviors online\n* Wear a Fitbit device to track sleep and activity during the study\n* Do brief homework assignments between sessions",[93,94],"PTSD - Post Traumatic Stress Disorder","Cardiac Arrest (CA)","2026-04-04",{"date":97,"type":98},"2026-04-09","ACTUAL",{"date":100,"type":98},"2026-03-31",{"date":102,"type":87},"2029-03-31",{"name":5,"class":6},1]