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City","Zigong",{"type":42,"coordinates":611},[612,613],104.77689,29.34162,{"lat":613,"lon":612},[616],{"name":617,"role":28,"phone":18,"phoneExt":18,"email":18},"chenghao yang",{"type":619,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100607371","trial-of-early-minimally-invasive-catheter-evacuation-with-thrombolysis-in-intracerebral-hemorrhage-100607371",false,"NCT07187687","TrIal of Early Minimally Invasive Catheter Evacuation With Thrombolysis in IntraCerebral Hemorrhage","TrIal of Early Minimally Invasive Catheter Evacuation With Thrombolysis in IntraCerebral Hemorrhage (TIME-ICH): A Prospective, Multi-center, Open-label, Adaptive, Randomized Controlled Trial","TIME-ICH","Inclusion Criteria:\n\n1. Age ≥ 18 years;\n2. Pre-randomization head CT demonstrating an acute, spontaneous, primary ICH;\n3. ICH volume ≥ 20mL as calculated by the ABC\u002F2 method;\n4. The randomization can be completed within 8 hours after the onset of stroke symptoms (or the time last known to be well), and study intervention can reasonably be initiated within 4 hours after randomization.\n5. Historical Modified Rankin Score 0 or 1;\n6. Obtain informed consent from patient or legal representative.\n\nExclusion Criteria:\n\n1. Infratentorial intraparenchymal hemorrhage including midbrain, pontine, or cerebellar;\n2. Ruptured aneurysm, arteriovenous malformation (AVM), vascular anomaly, Moyamoya disease, venous sinus thrombosis, mass or tumor, hemorrhagic conversion of an ischemic infarct, tumor stroke, recurrence of a recent (\\\u003C1 year) ICH, as diagnosed with radiographic imaging;\n3. Presence of spot sign in CT angiography;\n4. Blood pressure control before randomization is ineffective, systolic blood pressure \\> 220 mmHg;\n5. Irreversible impaired brain stem function (bilateral fixed, dilated pupils and extensor motor posturing), GCS ≤ 4;\n6. Hemorrhage with apparent midbrain extension with third nerve palsy or dilated and non-reactive pupils. Other (supranuclear) gaze abnormalities are not exclusions;\n7. Intraventricular extension of the Hemorrhage is visually estimated to involve \\>50% of either of the lateral ventricles;\n8. Any irreversible coagulopathy or known clotting disorder.\n9. Platelet count \\\u003C 750,000, INR \\> 1.4 after correction\n10. Patients requiring long-term anti-coagulation that needs to be initiated \\\u003C 30 days from index ICH;\n11. Use of 2 or more antithrombotic drugs prior to symptom onset;\n12. Patients with a mechanical heart valve;\n13. Positive urine or serum pregnancy test in female subjects without documented history of surgical sterilization or is post-menopausal;\n14. Urokinase allergy;\n15. Any concurrent serious illness that would interfere with the outcome assessments including hepatic, renal, gastroenterologic, respiratory, cardiovascular, endocrinologic, immunologic, and hematologic disease;\n16. Inability or unwillingness of patient or legal representative to give written informed consent;\n17. Known life-expectancy of less than 6 months;\n18. Participation in a concurrent interventional medical investigation or clinical trial.","ALL","18 Years",{"count":631,"type":632},750,"ESTIMATED","INTERVENTIONAL",[635],"NA","TIME-ICH (TrIal of early Minimally Invasive catheter Evacuation with thrombolysis in IntraCerebral Hemorrhage) is a multicenter, randomized, adaptive clinical trial comparing best medical management to early minimally invasive surgery with thrombolysis (eMIST) in the treatment of acute spontaneous supratentorial intracerebral hemorrhage.",[638],"Intracerebral Hemorrhage",[638,640,641,642,643,644,645,646,647,648,649,650,651,652],"Intracranial Hemorrhages","ICH","brain hemorrhage","Hemorrhage","Cerebrovascular Disorders","Brain Diseases","Minimally invasive catheter evacuation","Minimally invasive surgery","Neurosurgery","Thrombolysis","Urokinase","Medical Economic","Hospital Economics","2026-03-06",{"date":655,"type":656},"2026-03-09","ACTUAL",{"date":658,"type":656},"2025-10-24",{"date":660,"type":632},"2028-03-01",{"name":5,"class":6},50]