[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100482474":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":23,"centralContacts":28,"locations":38,"responsibleParty":138,"collaborators":140,"id":143,"slug":144,"hasResults":145,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":145,"sex":151,"minAge":152,"maxAge":153,"enrollmentInfo":154,"targetDuration":18,"studyType":157,"phases":158,"briefSummary":160,"conditions":161,"keywords":168,"overallStatus":41,"whyStopped":18,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":182},{"fullName":5,"class":6},"Australian and New Zealand Intensive Care Research Centre","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Venovenous ECMO","ACTIVE_COMPARATOR","Patients allocated to the ECMO strategy be initiated on V-V ECMO and on anticoagulation (blood thinning medication to prevent clot formation) within 24 hours of being allocated into the intervention group. Anticoagulant medication to prevent clot formation will be initiated as per current local practice for each site. Sites are encouraged to use best practice ECMO management that includes de-sedation, extubation, commencement of physiotherapy and rehabilitation,",[13],"Other: Venovenous ECMO",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard care","NO_INTERVENTION","Patients allocated to the standard care arm will receive routine intensive care for hypoxic respiratory failure, including mechanical ventilation as per local practices, weaning of sedation and assessment for extubation. Patients who continue to deteriorate will be eligible for initiation of V-V ECMO if they meet the ECMO to rescue lung injury in severe ARDS (EOLIA) criteria: Partial pressures of arterial oxygen (PaO2):Fraction of inspired oxygen (FiO2)\\\u003C50 for 3 hours, PaO2:FiO2\\\u003C80 for 6 hours, pH\\\u003C7.25 with PaCO2 \\>60 for \\>6 hours.",null,[20],{"type":6,"name":9,"description":21,"armGroupLabels":22,"otherNames":18},"ECMO therapy for patients with hypoxic respiratory failure.",[9],[24],{"name":25,"affiliation":26,"role":27},"Aidan Burrell, MBBS","Monash University","PRINCIPAL_INVESTIGATOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":18,"email":33},"Stephanie M Hunter","CONTACT","+61 3 9903 0646","Stephanie.Hunter@monash.edu",{"name":35,"role":31,"phone":36,"phoneExt":18,"email":37},"Tony Trapani","+61 3 9903 0343","Tony.Trapani@monash.edu",[39,56,67,79,93,108,124],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"St Vincent's Hospital Sydney","RECRUITING","Darlinghurst","New South Wales","2010","Australia","AU",{"type":48,"coordinates":49},"Point",[50,51],151.21925,-33.87939,{"lat":51,"lon":50},[54],{"name":55,"role":31,"phone":18,"phoneExt":18,"email":18},"Priya Nair",{"facility":57,"status":41,"city":58,"state":43,"zip":18,"country":45,"countryCode":46,"cosmosGeoPoint":59,"geoPoint":63,"contacts":64},"Royal Prince Alfred","Sydney",{"type":48,"coordinates":60},[61,62],151.20732,-33.86785,{"lat":62,"lon":61},[65],{"name":66,"role":31,"phone":18,"phoneExt":18,"email":18},"Richard Totaro",{"facility":68,"status":41,"city":69,"state":70,"zip":18,"country":45,"countryCode":46,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"The Prince Charles Hospital","Brisbane","Queensland",{"type":48,"coordinates":72},[73,74],153.02809,-27.46794,{"lat":74,"lon":73},[77],{"name":78,"role":31,"phone":18,"phoneExt":18,"email":18},"John Fraser",{"facility":80,"status":41,"city":81,"state":70,"zip":82,"country":45,"countryCode":46,"cosmosGeoPoint":83,"geoPoint":87,"contacts":88},"Gold Coast University Hospital","Gold Coast","4217",{"type":48,"coordinates":84},[85,86],153.43088,-28.00029,{"lat":86,"lon":85},[89,91],{"name":90,"role":31,"phone":18,"phoneExt":18,"email":18},"James McCullough, Doctor",{"name":92,"role":31,"phone":18,"phoneExt":18,"email":18},"Mandy Tallott",{"facility":94,"status":41,"city":95,"state":96,"zip":97,"country":45,"countryCode":46,"cosmosGeoPoint":98,"geoPoint":102,"contacts":103},"The Alfred Hospital","Melbourne","Victoria","3004",{"type":48,"coordinates":99},[100,101],144.96332,-37.814,{"lat":101,"lon":100},[104,106],{"name":105,"role":31,"phone":18,"phoneExt":18,"email":18},"Meredith Young",{"name":107,"role":27,"phone":18,"phoneExt":18,"email":18},"Andrew Udy",{"facility":109,"status":110,"city":111,"state":112,"zip":113,"country":45,"countryCode":46,"cosmosGeoPoint":114,"geoPoint":118,"contacts":119},"Fiona Stanley Hospital","NOT_YET_RECRUITING","Perth","Western Australia","6150",{"type":48,"coordinates":115},[116,117],115.8614,-31.95224,{"lat":117,"lon":116},[120,122],{"name":121,"role":31,"phone":18,"phoneExt":18,"email":18},"Chris Allen, Doctor",{"name":123,"role":31,"phone":18,"phoneExt":18,"email":18},"Annamaria Palermo",{"facility":125,"status":41,"city":126,"state":18,"zip":127,"country":128,"countryCode":129,"cosmosGeoPoint":130,"geoPoint":134,"contacts":135},"Charite Universitatmedizin","Berlin","10117","Germany","DE",{"type":48,"coordinates":131},[132,133],13.41053,52.52437,{"lat":133,"lon":132},[136],{"name":137,"role":31,"phone":18,"phoneExt":18,"email":18},"Jan-Matthias Kruse",{"type":139,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[141],{"name":142,"class":6},"The Alfred","100482474","trial-of-venovenous-ecmo-to-de-sedate-extubate-and-mobilise-in-hypoxic-respiratory-failure-100482474",false,"NCT05562505","Trial of Venovenous ECMO to De-Sedate, Extubate and Mobilise in Hypoxic Respiratory Failure","A Randomised Controlled Trial of Venovenous ECMO to De-Sedate, Extubate and Mobilise in Hypoxic Respiratory Failure","REDEEM","Inclusion Criteria:\n\n1. Patients ≥18 to 65 years old\n2. Acute hypoxemic respiratory failure characterised by new or worsening respiratory symptoms developing within 2 weeks prior to the onset of need for oxygen or respiratory support\n3. Mechanical ventilation of \\\u003C7 days\n4. Moderate to severe respiratory failure, as demonstrated by two P:F ratios \\\u003C150mmHg at least 6 hours apart. Arterial Blood Gases (ABG) with P:F ratio \\> 150mmHg are permitted between the two trial inclusion ABGs.\n5. Trial of proning (unless contraindicated)\n\nExclusion Criteria:\n\n1. The patient will be extubated today or tomorrow (i.e. will not remain intubated and ventilated the day after tomorrow)\n2. Cardiogenic cause of respiratory failure\n3. Chronic hypercapnic respiratory failure defined as PaCO2 \\> 60 mmHg in the outpatient setting\n4. Home mechanical ventilation (non-invasive ventilation or via tracheotomy) except for CPAP\u002FBIPAP used solely for sleep disordered breathing\n5. Confirmed diffuse alveolar haemorrhage from vasculitis\n6. Neurologic conditions, i.e. undergoing treatment for intracranial hypertension\n7. Currently receiving any form of ECMO (e.g., venovenous, venoarterial, or hybrid configuration)\n8. Patient needing immediate VV ECMO (as per EOLIA criteria)\n9. The patient is moribund and deemed unlikely to survive past 24 hours (as determined by the clinical team)\n10. The patient is being transitioned to palliative care\n11. Contraindications to anticoagulation (e.g., active GI bleeding, bleeding predisposition, severe trauma)\n12. Previous hypersensitivity\u002Fanaphylactic reaction to heparin or heparin-induced thrombocytopenia\n13. Participation or Consent is declined, OR\n14. Unable to identify or Contact surrogate decision maker.","ALL","18 Years","65 Years",{"count":155,"type":156},140,"ESTIMATED","INTERVENTIONAL",[159],"NA","To determine whether a strategy of adding venovenous ECMO to mechanical ventilation, as compared to mechanical ventilation alone, increases the number of intensive care free days at day 60, in patients with moderate to severe acute hypoxic respiratory failure.",[162,163,164,165,166,167],"Mechanical Ventilation Complication","Hypoxemia","Acute Respiratory Distress Syndrome Due to COVID-19","COVID-19 Respiratory Infection","Pneumonia","Extracorporeal Membrane Oxygenation",[169,170,167,171,172],"Intensive Care Unit","ECMO","Mechanical Ventilation","Early ECMO","2024-08-06",{"date":175,"type":176},"2024-08-09","ACTUAL",{"date":178,"type":176},"2022-11-28",{"date":180,"type":156},"2027-01-31",{"name":5,"class":6},7]