[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100619347":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":27,"locations":37,"responsibleParty":86,"collaborators":90,"id":96,"slug":97,"hasResults":98,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":98,"sex":104,"minAge":105,"maxAge":11,"enrollmentInfo":106,"targetDuration":11,"studyType":109,"phases":110,"briefSummary":112,"conditions":113,"keywords":116,"overallStatus":40,"whyStopped":11,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":130},{"fullName":5,"class":6},"University Hospital, Geneva","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Group - Indirect Calorimetry Group","EXPERIMENTAL",null,[13],"Other: Indirect Calorimetry Group",{"label":15,"type":16,"description":11,"interventionNames":17},"Control Group - Formula-Based Group","ACTIVE_COMPARATOR",[18],"Other: Control Group - Formula-Based Group",[20,24],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":11},"Indirect Calorimetry Group","* Nutritional targets measured by IC starting on Day 4\n* Repeated IC measurements 2 times weekly performed with the QNRG+ device\n* Gradual escalation to 80%-100% caloric coverage by Day 4",[9],{"type":6,"name":15,"description":25,"armGroupLabels":26,"otherNames":11},"* Nutritional targets determined using predictive equations (pragmatic, set at local level)\n* Escalation as per local protocol",[15],[28,33],{"name":29,"role":30,"phone":31,"phoneExt":11,"email":32},"Claudia Paula Heidegger, Prof.","CONTACT","+41223727440","claudia.heidegger@hug.ch",{"name":34,"role":30,"phone":35,"phoneExt":11,"email":36},"Aude de Watteville, MSc","+41795533998","aude.dewatteville@hug.ch",[38,60,73],{"facility":39,"status":40,"city":41,"state":11,"zip":11,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Geneva University Hospital","RECRUITING","Geneva","Switzerland","CH",{"type":45,"coordinates":46},"Point",[47,48],6.14569,46.20222,{"lat":48,"lon":47},[51,52,53,56,59],{"name":29,"role":30,"phone":31,"phoneExt":11,"email":32},{"name":34,"role":30,"phone":35,"phoneExt":11,"email":36},{"name":54,"role":55,"phone":11,"phoneExt":11,"email":11},"Claudia Heidegger, Prof.","PRINCIPAL_INVESTIGATOR",{"name":57,"role":58,"phone":11,"phoneExt":11,"email":11},"Hannah Wozniak, Dr. med","SUB_INVESTIGATOR",{"name":34,"role":58,"phone":11,"phoneExt":11,"email":11},{"facility":61,"status":40,"city":62,"state":11,"zip":11,"country":42,"countryCode":43,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"GHOL","Nyon",{"type":45,"coordinates":64},[65,66],6.23955,46.38318,{"lat":66,"lon":65},[69],{"name":70,"role":30,"phone":71,"phoneExt":11,"email":72},"Mallory Moret, Dr. med.","+41 (0)22 994 67 47","mallory.moretbochatay@ghol.ch",{"facility":74,"status":40,"city":75,"state":11,"zip":11,"country":42,"countryCode":43,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"Zürich University Hospitals","Zurich",{"type":45,"coordinates":77},[78,79],8.55,47.36667,{"lat":79,"lon":78},[82],{"name":83,"role":30,"phone":84,"phoneExt":11,"email":85},"Mattia Müller, Dr. med.","0794184324","mattia.muller@usz.ch",{"type":87,"investigatorFullName":88,"investigatorTitle":89,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"SPONSOR_INVESTIGATOR","HEIDEGGER CP","Prof",[91,93],{"name":92,"class":6},"University Hospital, Zürich",{"name":94,"class":95},"GHOL Nyon Hospital","UNKNOWN","100619347","trial-on-the-impact-of-indirect-calorimetry-guided-nutritional-support-on-patient-centered-outcomes-in-critically-ill-patients---the-optical-study-100619347",false,"NCT07343440","Trial on the Impact of Indirect Calorimetry-Guided Nutritional Support on Patient-Centered Outcomes in Critically Ill Patients - The OPTICal Study","A Randomized Controlled Trial on the Impact of Indirect Calorimetry-Guided Nutritional Support on Patient-Centered Outcomes in Critically Ill Patients - The OPTICal Study","OPTICal","Inclusion Criteria:\n\nAll patients admitted to the ICU with the following criteria:\n\n* ≥18 years old\n* On Mechanical Ventilation\n* Expected ICU length of stay \\>72 hours\n\nExclusion Criteria:\n\n* Refusal of the family or patient\n* Patient transferred from another ICU\n* Pregnant patient\n* Patient is planned for a withdrawal of care or is actively dying\n* Cognitive disorder before ICU\n* Patient is in jail\n* Patients already enrolled in the ongoing NutriPhyT trial","ALL","18 Years",{"count":107,"type":108},356,"ESTIMATED","INTERVENTIONAL",[111],"NA","This multicentric randomized controlled trial aims to evaluate whether indirect calorimetry (IC)-guided nutritional support improves patient-centered outcomes in critically ill adult patients compared to standard formula-based nutritional strategies. The study includes mechanically ventilated patients expected to remain in the ICU for more than 72 hours. The intervention group will receive nutritional targets based on measured resting energy expenditure using the QNRG+ device, with a gradual escalation of energy delivery following current ESPEN guidelines. The primary outcome is quality of life at 3 months post-ICU admission, assessed using the EQ-5D-5L. Secondary outcomes include functional recovery, muscle preservation, infection rates, and rehospitalization. This study is the first to assess the long-term impact of IC-guided nutrition on recovery and quality of life using a patient-centered approach.",[114,115],"Critical Illness","ICU",[117,118,119,120],"Nutrition","Indirect calorimetry","Nutrition therapy","Predictive formula","2026-05-15",{"date":123,"type":124},"2026-05-19","ACTUAL",{"date":126,"type":124},"2026-01-01",{"date":128,"type":108},"2027-09-01",{"name":88,"class":6},3]