[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100536416":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":29,"locations":36,"responsibleParty":50,"collaborators":52,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":56,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":11,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":81,"whyStopped":11,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"S.LAB (SOLOWAYS)","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"zinc, selenium, and L-tyrosine supplementation","EXPERIMENTAL",null,[13],"Dietary Supplement: zinc, selenium, and L-tyrosine in SEPP1",{"label":15,"type":16,"description":11,"interventionNames":17},"placebo group","PLACEBO_COMPARATOR",[18],"Other: Placebo",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DIETARY_SUPPLEMENT","zinc, selenium, and L-tyrosine in SEPP1","zinc, selenium, and L-tyrosine in SEPP1 polymorphism",[9],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Placebo","placebo comparator in SEPP1 polymorphism group",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":34,"email":35},"Andrey V Ponomarenko, MD","CONTACT","9628316017","+7","dasyshadoff@gmail.com",[37],{"facility":38,"status":11,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":11},"Center of New Medical Technologies","Novosibirsk","Novosibisk Region","630090","Russia","RU",{"type":45,"coordinates":46},"Point",[47,48],82.93175,55.02259,{"lat":48,"lon":47},{"type":51,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR",[53],{"name":38,"class":6},"100536416","trial-to-evaluate-the-efficacy-of-a-zinc-selenium-and-l-tyrosine-supplement-in-the-prevention-of-thyrotoxicosis-in-subjects-with-r25191ga-sepp1-polymorphism-100536416",false,"NCT06264544","Trial to Evaluate the Efficacy of a Zinc, Selenium, and L-Tyrosine Supplement in the Prevention of Thyrotoxicosis in Subjects With r25191G\u002FA SEPP1 Polymorphism","A Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Efficacy of a Zinc, Selenium, and L-Tyrosine Supplement in the Prevention of Thyrotoxicosis in Subjects With r25191G\u002FA SEPP1 Polymorphism","ZEST-PREP","Inclusion Criteria:\n\n* Confirmed presence of one or more specified gene polymorphism r25191G\u002FA SEPP1\n* TPOAb levels \\> 300 IU\u002FmL\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years and \\>85\n* Pregnant or breastfeeding woman\n* Subjects with allergy to any of the supplementation component patients with any established diagnosis of thyroid disease","ALL","18 Years","85 Years",{"count":66,"type":67},150,"ESTIMATED","INTERVENTIONAL",[70],"NA","This randomized, double-blind, placebo-controlled trial evaluates the efficacy of a zinc, selenium, and L-tyrosine supplement in preventing thyrotoxicosis among adults aged 18-85 with elevated TPOAb levels and the r25191G\u002FA SEPP1 polymorphism. The study excludes those with thyroid disease, pregnant\u002Fbreastfeeding women, and individuals allergic to the supplement. Key endpoints include changes in thyroid antibodies and hormones over a 6-month period. With an estimated sample size of 150 participants per group, accounting for a 20% dropout rate, the trial seeks to demonstrate the supplement's potential in reducing thyrotoxicosis risk through a genetically-informed approach.",[73],"Thyrotoxicosis",[75,76,77,78,79,80],"Thyrotoxicosis Prevention","SEPP1 Polymorphism","Zinc, Selenium, and L-Tyrosine Supplementation","supplementation","Nutrigenomics","Thyroid Peroxidase Antibodies (TPOAb)","NOT_YET_RECRUITING","2025-06-06",{"date":84,"type":85},"2025-06-08","ACTUAL",{"date":87,"type":67},"2025-07-30",{"date":89,"type":67},"2025-12-30",{"name":5,"class":6},1]