[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100398242":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":33,"responsibleParty":83,"collaborators":10,"id":86,"slug":87,"hasResults":88,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":88,"sex":94,"minAge":95,"maxAge":10,"enrollmentInfo":96,"targetDuration":99,"studyType":100,"phases":10,"briefSummary":101,"conditions":102,"keywords":105,"overallStatus":36,"whyStopped":10,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},{"fullName":5,"class":6},"University of Turku","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Myocardial infarction",null,"Recruited patients with STEMI or NSTEMI and elevated Troponin T",[13],"Diagnostic Test: troponin T fragmentation test",{"label":15,"type":10,"description":16,"interventionNames":17},"Myocardial injury","Recruited patients with myocardial injury based on elevated Troponin T and associated with renal failure, severe infection, strenouos exercise, atrial fibrillation, myocarditis, takotsubo cardiomyopathy or other similar conditions.\n\nPatients undergoing interventions konow to cause troponin elevations, e.g. heart surgery, TAVI operations, catheter ablation of atrial fibrillation, PCI.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","troponin T fragmentation test","laboratory test from blood sample",[9,15],[25],{"name":26,"affiliation":5,"role":27},"Juhani K Airaksinen, MD, PhD","PRINCIPAL_INVESTIGATOR",[29],{"name":26,"role":30,"phone":31,"phoneExt":10,"email":32},"CONTACT","+358 2 3131005","juhani.airaksinen@tyks.fi",[34,71],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Turku University Hospital, Heart Center","RECRUITING","Turku","Southwest Finland","20521","Finland","FI",{"type":43,"coordinates":44},"Point",[45,46],22.26869,60.45148,{"lat":46,"lon":45},[49,52,56,57,60,62,63,65,67,69],{"name":50,"role":30,"phone":51,"phoneExt":10,"email":32},"Juhani KE Airaksinen, MD, PhD","+358 2 313 1079",{"name":53,"role":30,"phone":54,"phoneExt":10,"email":55},"Samuli Jaakkola, MD, PhD","+358 2 3138 025","samuli.jaakkola@tyks.fi",{"name":26,"role":27,"phone":10,"phoneExt":10,"email":10},{"name":58,"role":59,"phone":10,"phoneExt":10,"email":10},"Saara Wittfooth, PhD","SUB_INVESTIGATOR",{"name":61,"role":59,"phone":10,"phoneExt":10,"email":10},"Tapio Hellman, MD, PhD",{"name":53,"role":59,"phone":10,"phoneExt":10,"email":10},{"name":64,"role":59,"phone":10,"phoneExt":10,"email":10},"Kaj Metsärinne, MD, PhD",{"name":66,"role":59,"phone":10,"phoneExt":10,"email":10},"Rami Aalto, MSc",{"name":68,"role":59,"phone":10,"phoneExt":10,"email":10},"Tuomas Paana, MD",{"name":70,"role":59,"phone":10,"phoneExt":10,"email":10},"Kim Pettersson, MD, PhD",{"facility":72,"status":73,"city":74,"state":10,"zip":75,"country":76,"countryCode":77,"cosmosGeoPoint":78,"geoPoint":82,"contacts":10},"University Hospital Zurich","ENROLLING_BY_INVITATION","Zurich","8091 Zurich","Switzerland","CH",{"type":43,"coordinates":79},[80,81],8.55,47.36667,{"lat":81,"lon":80},{"type":27,"investigatorFullName":84,"investigatorTitle":85,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Juhani Airaksinen","Professor","100398242","troponin-fragmentation-in-myocardial-injury-study-100398242",false,"NCT04465591","TROPOnin FRAGMentation in Myocardial Injury Study","Troponin T Fragmentation in the Assessment of Myocardial Injury Study","Tropo-Fragm","Inclusion Criteria:\n\n* Troponin T fragmentation sample collected from a recruited patient.\n\nExclusion Criteria:\n\n* Age \\\u003C18","ALL","18 Years",{"count":97,"type":98},1500,"ESTIMATED","1 Year","OBSERVATIONAL","Troponin T (TnT) is a part of the troponin protein complex that principally exists in cardiac and skeletal muscle cells and is widely used as diagnostic biomarker for myocardial injury and, thus, myocardial infarction (MI). Elevated TnT levels can, however, be observed in the presence of other clinical conditions such as heart failure, sepsis and kidney failure and the contemporary high-sensitivity TnT test may yield false positive results when performing diagnostics for suspected MI in these patients.\n\nRecent data have demonstrated that in the presence of MI, TnT gradually undergoes fragmentation into smaller fragments. It has been suggested that in the presence of e.g. chronic kidney disease or physical exercise the released TnT is predominantly in the form of smaller fragments.\n\nHowever, the clinical significance of TnT fragmentation is unknown and, thus, we sought to investigate the prevalence of fragmentation of TnT in different patient cohorts.",[103,104],"Acute Myocardial Infarction Type 1","Myocardial Injury",[106,107,108],"Troponin","myocardial injury","myocardial infarction","2026-05-04",{"date":111,"type":112},"2026-05-08","ACTUAL",{"date":114,"type":112},"2020-04-02",{"date":116,"type":98},"2028-12-31",{"name":5,"class":6},2]