[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631749":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":19,"locations":25,"responsibleParty":76,"collaborators":10,"id":80,"slug":81,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":10,"eligibilityCriteria":86,"healthyVolunteers":82,"sex":87,"minAge":88,"maxAge":10,"enrollmentInfo":89,"targetDuration":10,"studyType":92,"phases":10,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Zhongda Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Intubated mechanically ventilated ARDS patients",null,"Intubated mechanically ventilated patients with moderate to severe ARDS according to the Berlin definition",[13],"Other: Specific lung recruitment maneuvers and decremental PEEP steps",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Specific lung recruitment maneuvers and decremental PEEP steps","Specific lung recruitment maneuvers will be performed to measure the potential for lung recruitment. Followed by a decremental PEEP steps to determine lung mechanics at different PEEP levels. These process will be repeated when patients change to another position. Electrical impedance tomography signals, synchronized signals of airway pressure and flow, esophageal pressure will be recorded continuously.",[9],[20],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Fengmei Guo, M.D","CONTACT","+8618255127433","fmguo2022@163.com",[26,45,60],{"facility":27,"status":28,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"Zhongda Hospital, Southeast University","RECRUITING","Nanjing","Jiangsu","210009","China","CN",{"type":35,"coordinates":36},"Point",[37,38],118.77778,32.06167,{"lat":38,"lon":37},[41],{"name":42,"role":22,"phone":43,"phoneExt":10,"email":44},"Zhichang Wang","+8615261887038","wang15zc@163.com",{"facility":46,"status":28,"city":47,"state":48,"zip":49,"country":32,"countryCode":33,"cosmosGeoPoint":50,"geoPoint":54,"contacts":55},"The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital","Jinan","Shandong","250014",{"type":35,"coordinates":51},[52,53],116.99722,36.66833,{"lat":53,"lon":52},[56],{"name":57,"role":22,"phone":58,"phoneExt":10,"email":59},"Yidan Wang, M.D.","+8617865150360","sofardan@163.com",{"facility":61,"status":62,"city":63,"state":64,"zip":65,"country":32,"countryCode":33,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"West China Hospital of Sichuan University","NOT_YET_RECRUITING","Chengdu","Sichuan","610041",{"type":35,"coordinates":67},[68,69],104.06667,30.66667,{"lat":69,"lon":68},[72],{"name":73,"role":22,"phone":74,"phoneExt":10,"email":75},"Hao He, M.D.","+8613858878793","dr_hehao@163.com",{"type":77,"investigatorFullName":78,"investigatorTitle":79,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Fengmei Guo","Deputy director","100631749","trunk-inclination-positive-end-expiratory-pressure-and-lung-recruitability-100631749",false,"NCT07504731","Trunk Inclination, Positive End-expiratory Pressure, and Lung Recruitability","Impact of Trunk Inclination on Lung Mechanics According to PEEP and Reruitability","Inclusion Criteria:\n\n* Intubated moderate and severe ARDS according to the Berlin definition (PaO2\u002FFiO2 ratio \\\u003C= 200 mmHg)\n* Under continuous sedation with or without paralysis\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* Bronchopleural fistula\n* Pure COPD exacerbation\n* Contraindication to EIT monitoring (e.g. burns, pacemaker, thoracic wounds limiting electrode belt placement)\n* Hemodynamic instability (Systolic BP \\\u003C 75 mmHg or MAP \\\u003C 60 mmHg despite vasopressors and\u002For heart rate \\\u003C 55 bpm)\n* Contraindications to mobilization (e.g., intracranial hypertension, spinal cord injury)\n* Intra-abdominal hypotension (IAP≥12mmHg)\n* Pregnancy\n* Attending physician deems the transient application of high airway pressures to be unsafe","ALL","18 Years",{"count":90,"type":91},40,"ESTIMATED","OBSERVATIONAL","This multicenter, physiological, observational study hypothesizes that in moderate to severe ARDS, trunk inclination unloads the chest wall, but its impact on lung mechanics depends on PEEP levels and lung recruitability.",[95],"Acute Respiratory Distress Syndrome (ARDS)",[97,98,99,100],"trunk inclination","lung mechanics","positive end-expiratory pressure","lung recruitability","2026-03-25",{"date":103,"type":104},"2026-04-01","ACTUAL",{"date":106,"type":104},"2026-03-20",{"date":108,"type":91},"2027-04-30",{"name":5,"class":6},3]