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Alternative for Risk-reducing Salpingo-oophorectomy in High Risk Women to Assess the Safety of Prevention: TUBA-WISP II Study.","TUBA-WISP-II","Inclusion Criteria:\n\n* Women with a class 5 (definitely pathogenic) BRCA1, BRCA2, RAD51C, RAD51D or BRIP1 germline mutation in one of the participating centers.\n* Age at inclusion;\n\n  * BRCA1: 25-40 years\n  * BRCA2: 25-45 years\n  * RAD51C, RAD51D, BRIP1: 25-50 years\n* Childbearing completed\n* Presence of at least one fallopian tube\n* Participants may have a personal history of non-ovarian malignancy\n* Informed consent must be obtained and documented according to national and local regulatory requirements and the local rules followed in the institution.\n\nExclusion Criteria:\n\n* Postmenopausal status (natural menopause or due to treatment)\n* Wish for second stage RRO within two years after RRS\n* Legally incapable\n* Prior bilateral salpingectomy\n* A personal history of ovarian, fallopian tube or peritoneal cancer\n* Current diagnosis or treatment for malignant disease","FEMALE","25 Years","50 Years",{"count":807,"type":808},3000,"ESTIMATED","INTERVENTIONAL",[811],"NA","The aim of the project is to evaluate the risk-reducing salpingectomy with delayed oophorectomy as an alternative for risk-reducing salpingo-oophorectomy in high risk women with respect to ovarian cancer incidence.",[814,815,816,817,818,819],"BRCA1 Gene Mutation","BRCA2 Gene Mutation","RAD51C Gene Mutation","RAD51D Gene Mutation","BRIP1 Gene Mutation","Ovarian Cancer","2026-03-31",{"date":822,"type":823},"2026-04-06","ACTUAL",{"date":825,"type":823},"2020-03-01",{"date":827,"type":808},"2040-02-17",{"name":5,"class":6},66]