[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630061":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":21,"locations":10,"responsibleParty":27,"collaborators":10,"id":31,"slug":32,"hasResults":33,"nctId":34,"briefTitle":35,"officialTitle":36,"acronym":37,"eligibilityCriteria":38,"healthyVolunteers":33,"sex":39,"minAge":40,"maxAge":41,"enrollmentInfo":42,"targetDuration":10,"studyType":45,"phases":10,"briefSummary":46,"conditions":47,"keywords":49,"overallStatus":56,"whyStopped":10,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":10},{"fullName":5,"class":6},"Nanjing Medical University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"ESCC Patients Receiving Neoadjuvant Chemo-Immunotherapy",null,"Patients with pathologically confirmed esophageal squamous cell carcinoma who are scheduled to receive standard neoadjuvant chemotherapy combined with immunotherapy followed by surgical resection. Tumor tissue samples will be collected before treatment and at the time of surgery for translational analyses of tumor microenvironment changes associated with treatment response.",[13],"Other: Biological: Tumor Tissue and Blood Sample Collection",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Biological: Tumor Tissue and Blood Sample Collection","Tumor tissue samples will be collected at baseline before treatment and again at the time of surgical resection. Peripheral blood samples may also be collected when feasible. Collected biospecimens will be used for single-cell RNA sequencing, spatial transcriptomics, and related molecular analyses to evaluate dynamic changes in the tumor microenvironment associated with treatment response.",[9],[20],"Biospecimen Collection",[22],{"name":23,"role":24,"phone":25,"phoneExt":10,"email":26},"Zhiyun Xu, M.D.","CONTACT","+86 15251759696","zhiyunxu2012@njmu.edu.cn",{"type":28,"investigatorFullName":29,"investigatorTitle":30,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Zhiyun Xu","Principal Investigator","100630061","tumor-microenvironment-changes-after-neoadjuvant-chemo-immunotherapy-in-esophageal-squamous-cell-carcinoma-100630061",false,"NCT07482774","Tumor Microenvironment Changes After Neoadjuvant Chemo-Immunotherapy in Esophageal Squamous Cell Carcinoma","Dynamic Characterization of Tumor Microenvironment Remodeling and Immune Escape After Neoadjuvant Chemo-Immunotherapy in Esophageal Squamous Cell Carcinoma Using Single-Cell and Spatial Transcriptomics","TME-ESCC","Inclusion Criteria:\n\nAge 18 to 80 years; Pathologically confirmed esophageal squamous cell carcinoma; Potentially resectable disease and planned to receive standard neoadjuvant chemotherapy combined with immunotherapy followed by surgery; ECOG performance status 0 to 2; Adequate major organ function as judged by the investigator; Willing to provide tumor tissue samples at baseline and at the time of surgery; peripheral blood samples may also be collected when feasible; Written informed consent provided;\n\nExclusion Criteria:\n\nPrior treatment with immune checkpoint inhibitors; Active infection, immunodeficiency, or autoimmune disease requiring systemic immunosuppressive therapy; Pregnancy or breastfeeding; Contraindications to study-related tissue sampling or planned surgery; Inability to comply with study procedures or follow-up;","ALL","18 Years","80 Years",{"count":43,"type":44},12,"ESTIMATED","OBSERVATIONAL","This prospective observational study aims to characterize dynamic changes in the tumor microenvironment of patients with esophageal squamous cell carcinoma receiving standard neoadjuvant chemotherapy combined with immunotherapy followed by surgical resection. Paired tumor tissue samples will be collected before treatment and at surgery, and peripheral blood samples may also be collected when feasible. Single-cell RNA sequencing and spatial transcriptomics will be used to evaluate changes in cellular composition, transcriptional states, and spatial organization within the tumor microenvironment and to explore their associations with pathological response.",[48],"Esophageal Squamous Cell Carcinoma",[50,51,52,53,54,55],"Tumor Microenvironment","Neoadjuvant Chemoimmunotherapy","Single-Cell RNA Sequencing","Spatial Transcriptomics","Pathological Response","Immune Escape","NOT_YET_RECRUITING","2026-03-16",{"date":59,"type":60},"2026-03-19","ACTUAL",{"date":62,"type":44},"2026-06-01",{"date":64,"type":44},"2027-12-31",{"name":5,"class":6}]