[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100258134":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":17,"locations":26,"responsibleParty":47,"collaborators":10,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":10,"eligibilityCriteria":54,"healthyVolunteers":51,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":10,"studyType":61,"phases":10,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"National Institutes of Health Clinical Center (CC)","NIH",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients",null,"Patients who have solitary primary or recurrent brain tumor with associated seizures.",[13],{"name":14,"affiliation":15,"role":16},"Kareem A Zaghloul, M.D.","National Institute of Neurological Disorders and Stroke (NINDS)","PRINCIPAL_INVESTIGATOR",[18,23],{"name":19,"role":20,"phone":21,"phoneExt":10,"email":22},"Gretchen C Scott, R.N.","CONTACT","(301) 496-2921","SNBrecruiting@nih.gov",{"name":14,"role":20,"phone":24,"phoneExt":10,"email":25},"(301) 594-8114","zaghloulka@mail.nih.gov",[27],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"National Institutes of Health Clinical Center","RECRUITING","Bethesda","Maryland","20892","United States","US",{"type":36,"coordinates":37},"Point",[38,39],-77.10026,38.98067,{"lat":39,"lon":38},[42],{"name":43,"role":20,"phone":44,"phoneExt":45,"email":46},"For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)","800-411-1222","TTY dial 711","ccopr@nih.gov",{"type":48,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100258134","tumor-related-epilepsy-100258134",false,"NCT02639325","Tumor Related Epilepsy","* INCLUSION CRITERIA:\n\nTo be eligible for entry into the study, a candidate must meet all the following criteria:\n\n* Be 8 years of age or older.\n* Have solitary primary or recurrent brain tumor with associated seizures. Brain tumor may be diagnosed radiologically. Associated seizures are defined as those with activity starting within three months of radiologic diagnosis of the primary or recurrent tumor. In cases when the timing of seizure activity is unclear with respect to the timing of diagnosis, seizures will be considered associated with the tumor if seizure semiology is consistent with that location. Ongoing seizures are not required. Patients can be included if they have had a single previous seizure. Patients who have not experienced seizures after institution of anti-convulsant therapy are not excluded.\n\nEXCLUSION CRITERIA:\n\nCandidates will be excluded if they:\n\n-At the time of enrollment, lack consent capacity due to cognitive impairment that would make them incapable of understanding the explanation of the procedures in this study. Cognitive capacity to consent will be determined at the time of enrollment. Patients with mental disorders or those patients who are cognitively impaired yet still retain consent capacity will not be excluded. Children may be enrolled if there is a parent or guardian able to consent on their behalf.","ALL","8 Years","99 Years",{"count":59,"type":60},100,"ESTIMATED","OBSERVATIONAL","Background:\n\nSome people with brain tumors have seizures related to the tumor. This is called tumor-related epilepsy. Usually brain tumors are treated by removing as much of the brain tumor as possible without causing problems. Researchers think this may improve the outcome for people with brain tumors. It may completely relieve or greatly reduce the number of seizures they have.\n\nObjectives:\n\nTo evaluate people with brain tumors that are associated with seizures and to offer surgical treatment. Also, to study how surgery affects seizures.\n\nEligibility:\n\nPeople age 8 and older who have a brain tumor with associated seizures. They must be willing to have brain surgery to treat their epilepsy.\n\nDesign:\n\nParticipants will be screened with a review of their medical records.\n\nParticipants will have a medical history and physical exam.\n\nParticipants will be admitted to the hospital at NIH. They will have\n\nMedical history\n\nPhysical exam\n\nNeurological exam\n\nTests of memory, attention, and thinking\n\nQuestions about their symptoms and quality of life\n\nBlood drawn\n\nThey may also have:\n\nMRI or CT scan. They will lie on a table that slides in and out of a machine that takes pictures. For part of the MRI, they will get a dye through an intravenous (IV) catheter.\n\nVideo electroencephalography monitoring. Electrodes will be placed on the scalp. The participant s brain waves will be recorded while doing normal activities. Participants will be videotaped.\n\nParticipants will keep a seizure diary before and after surgery.\n\nParticipants will have surgery to remove their brain tumor and the brain area where their seizures start.\n\nThey will stay in the hospital up to a week after surgery.\n\nParticipants have for follow-up visits at NIH.",[64,65,66],"Epilepsy","Cancer","Brain Neoplasm",[68,69,70,71,72],"Brain Tumor","Brain Cancer","Seizure Disorder","Seizures","Natural History","2026-06-18",{"date":75,"type":76},"2026-06-22","ACTUAL",{"date":78,"type":76},"2016-01-26",{"date":80,"type":60},"2032-07-01",{"name":15,"class":6},1]