[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100375602":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":24,"locations":34,"responsibleParty":204,"collaborators":10,"id":206,"slug":207,"hasResults":208,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":212,"eligibilityCriteria":213,"healthyVolunteers":208,"sex":214,"minAge":215,"maxAge":10,"enrollmentInfo":216,"targetDuration":10,"studyType":219,"phases":10,"briefSummary":220,"conditions":221,"keywords":225,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":230,"lastUpdatePostDateStruct":231,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":239},{"fullName":5,"class":6},"Hospices Civils de Lyon","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with bone metastases at risk of fracture",null,"Adult patients with tumor osteolytic bone lesions located in proximal femur and\u002For vertebrae secondary to a myeloma or a breast, lung (NSCL: Non-Small Cell Lung), bladder, thyroid or kidney cancer. The target vertebrae or femur has to be naïve of localized treatment (interventional radiology - cementoplasty, cryotherapy, radiofrequency…). Previous exposure to systemic oncological treatments (chemotherapy, targeted therapy, immunotherapy…) and bone treatments are allowed if administered for less than 3 months.",[13],"Other: Evaluation of the fracture risk using data from routine qCT (quantitative Computed Tomography) scan and numerical simulation",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Evaluation of the fracture risk using data from routine qCT (quantitative Computed Tomography) scan and numerical simulation","Assessment of the mechanical tumor bone strength by numerical simulation using qCT routine imagery of proximal femur (applying a monopodal standing load) and vertebrae (applying a uniaxial compression load).",[9],[20],{"name":21,"affiliation":22,"role":23},"Cyrille CONFAVREUX, PR","Service de Rhumatologie","PRINCIPAL_INVESTIGATOR",[25,30],{"name":21,"role":26,"phone":27,"phoneExt":28,"email":29},"CONTACT","4.78.86.12.31","+33","cyrille.confavreux@chu-lyon.fr",{"name":31,"role":26,"phone":32,"phoneExt":28,"email":33},"Sara CALATTINI","4.78.86.37.79","sara.calattini@chu-lyon.fr",[35,53,67,81,95,109,123,137,147,160,174,190],{"facility":36,"status":37,"city":38,"state":10,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Service de rhumatologie, CHU d'Angers","RECRUITING","Angers","49100","France","FR",{"type":43,"coordinates":44},"Point",[45,46],-0.55202,47.47156,{"lat":46,"lon":45},[49],{"name":50,"role":26,"phone":51,"phoneExt":28,"email":52},"Béatrice BOUVARD","2 41 35 35 76","bebouvard@chu-angers.fr",{"facility":54,"status":37,"city":55,"state":10,"zip":56,"country":40,"countryCode":41,"cosmosGeoPoint":57,"geoPoint":61,"contacts":62},"Ch Annecy Genevois","Annecy","74000",{"type":43,"coordinates":58},[59,60],6.12565,45.90878,{"lat":60,"lon":59},[63],{"name":64,"role":26,"phone":65,"phoneExt":10,"email":66},"Frédérique ORSINI-PIOCELLE","0450636144","forsinipiocelle@ch-annecy-genevois.fr",{"facility":68,"status":37,"city":69,"state":10,"zip":70,"country":40,"countryCode":41,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Service de radiothérapie, Institut Jean-Perrin","Clermont-Ferrand","63011",{"type":43,"coordinates":72},[73,74],3.08682,45.77969,{"lat":74,"lon":73},[77],{"name":78,"role":26,"phone":79,"phoneExt":28,"email":80},"Aurélie BELLIERE","4 73 27 81 42","aurelie.belliere@laposte.net",{"facility":82,"status":37,"city":83,"state":10,"zip":84,"country":40,"countryCode":41,"cosmosGeoPoint":85,"geoPoint":89,"contacts":90},"Service de rhumatologie, CH Annemasse","Contamine-sur-Arve","74130",{"type":43,"coordinates":86},[87,88],6.33215,46.14223,{"lat":88,"lon":87},[91],{"name":92,"role":26,"phone":93,"phoneExt":28,"email":94},"Arnaud MAZOUYES","4 50 82 29 81","amazouyes@ch-alpes-léman.fr",{"facility":96,"status":37,"city":97,"state":10,"zip":98,"country":40,"countryCode":41,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"Service d'onco-rhumatologie, Centre Oscar Lombret","Lille","59000",{"type":43,"coordinates":100},[101,102],3.05512,50.63391,{"lat":102,"lon":101},[105],{"name":106,"role":26,"phone":107,"phoneExt":28,"email":108},"Marie-Hélène VIEILLARD","3 20 44 40 58","mh-vieillard@chru-lille.fr",{"facility":110,"status":37,"city":111,"state":10,"zip":112,"country":40,"countryCode":41,"cosmosGeoPoint":113,"geoPoint":117,"contacts":118},"Service de Radiothérapie, Centre Léon Bérard, 28 Prom. Léa et Napoléon Bullukian","Lyon","69008",{"type":43,"coordinates":114},[115,116],4.84789,45.74906,{"lat":116,"lon":115},[119],{"name":120,"role":26,"phone":121,"phoneExt":28,"email":122},"Line CLAUDE","4 78 78 26 49","line.claude@lyon.unicancer.fr",{"facility":124,"status":37,"city":125,"state":10,"zip":126,"country":40,"countryCode":41,"cosmosGeoPoint":127,"geoPoint":131,"contacts":132},"Service d'oncologie médicale, Institut Curie, 26 rue d'Ulm","Paris","75014",{"type":43,"coordinates":128},[129,130],2.3488,48.85341,{"lat":130,"lon":129},[133],{"name":134,"role":26,"phone":135,"phoneExt":28,"email":136},"Nicolas GIRARD","1 56 61 62 50","nicolas.girard2@curie.fr",{"facility":138,"status":37,"city":125,"state":10,"zip":126,"country":40,"countryCode":41,"cosmosGeoPoint":139,"geoPoint":141,"contacts":142},"Service de Radiologie, Hôpital Cochin, Assistance Publique - Hôpitaux de Paris",{"type":43,"coordinates":140},[129,130],{"lat":130,"lon":129},[143],{"name":144,"role":26,"phone":145,"phoneExt":28,"email":146},"Antoine FEYDY","1 58 41 24 83","antoine.feydy@aphp.fr",{"facility":148,"status":37,"city":149,"state":10,"zip":150,"country":40,"countryCode":41,"cosmosGeoPoint":151,"geoPoint":155,"contacts":156},"Service de Rhumatologie, Hospices Civils de Lyon, Groupement Hospitalier Lyon Sud","Pierre-Bénite","69310",{"type":43,"coordinates":152},[153,154],4.82424,45.70359,{"lat":154,"lon":153},[157],{"name":21,"role":26,"phone":158,"phoneExt":28,"email":159},"4 78 86 12 31","Cyrille.confavreux@chu-lyon.fr",{"facility":161,"status":37,"city":162,"state":10,"zip":163,"country":40,"countryCode":41,"cosmosGeoPoint":164,"geoPoint":168,"contacts":169},"Service de rhumatologie, CHU de Poitiers","Poitiers","86021",{"type":43,"coordinates":165},[166,167],0.34348,46.58261,{"lat":167,"lon":166},[170],{"name":171,"role":26,"phone":172,"phoneExt":28,"email":173},"Guillaumd LARID","05 49 44 44 65","guillaume.larid@chu-poitiers.fr",{"facility":175,"status":37,"city":176,"state":10,"zip":177,"country":40,"countryCode":41,"cosmosGeoPoint":178,"geoPoint":182,"contacts":183},"Service de rhumatologie, CHU de Saint Etienne","Saint-Priest-en-Jarez","42270",{"type":43,"coordinates":179},[180,181],4.37678,45.4739,{"lat":181,"lon":180},[184,187],{"name":185,"role":26,"phone":186,"phoneExt":28,"email":10},"Thierry THOMAS","4 77 12 76 42",{"name":188,"role":26,"phone":186,"phoneExt":28,"email":189},"Karima BOUSSOUALI","Karima.boussoualim@chu-st-etienne.fr",{"facility":191,"status":37,"city":192,"state":10,"zip":193,"country":40,"countryCode":41,"cosmosGeoPoint":194,"geoPoint":198,"contacts":199},"Institut de Cancérologie de Lorraine","Vandœuvre-lès-Nancy","54500",{"type":43,"coordinates":195},[196,197],6.17114,48.66115,{"lat":197,"lon":196},[200],{"name":201,"role":26,"phone":202,"phoneExt":10,"email":203},"Selima SELLAMI","03 83 59 84 00","s.sellami@nancy.unicancer.fr",{"type":205,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100375602","tumoral-bone-strength-assessment-by-numerical-simulation-using-quantitative-ct--the-mekanos-study-100375602",false,"NCT04170634","Tumoral Bone Strength Assessment by Numerical Simulation Using Quantitative CT : the MEKANOS Study","Tumoral Bone Strength Assessment by Numerical Simulation Using Quantitative CT (Computed Tomography) : the MEKANOS Study","MEKANOS","Inclusion Criteria:\n\n* Adult patients (\\> 18 years of age).\n* Patients who do not object to participating in the study. For patients participating to the biological collection: signature of the written informed consent..\n* Patients with secondary tumor lesion(s) of mammary or pulmonary non-small cell, renal, bladder, thyroid or myeloma bone origin.\n* Existence of a CT scan focused on the target lesion (or which will be performed as part of the care), performed within a time window of 30 days before and 20 days after inclusion, as part of the patient's usual bone management.\n* Target location: upper end of the femur (1\u002F3 proximal) and\u002For vertebrae. Several locations are possible for the same patient, provided that the inclusion criteria are met for each target.\n* Size of target lesion: either diffuse permeative or \\> 15 mm in size.\n* Exposure to systemic bone therapy for 3 months or less (daily clodronate or denosumab, zoledronic acid, monthly pamidronate) is allowed\n* Patients who received previous systemic oncological treatments (chemotherapy, targeted therapy, immunotherapy…) are eligible.\n\nExclusion Criteria:\n\n* Patients who have received targeted treatment at the target location either in the form of radiotherapy, surgery or interventional radiology (cementoplasty, cryotherapy, radiofrequency).\n* Fractured pathological target bone.\n* For the femur target, the patient must not have a hip prosthesis on either side (target or contralateral)\n* Patients under trusteeship.","ALL","18 Years",{"count":217,"type":218},220,"ESTIMATED","OBSERVATIONAL","Osteolytic bone metastases and myeloma bone lesions are responsible of long bone and vertebral fractures leading to restricted mobility, surgery and medullar compression that severely alter quality of life and that have a huge medico-economic impact. It has been estimated that 50% of the patients with bone metastasis will encounter bone complications. In the recent years, Bone Oncology Multidisciplinary Meetings have been developed to optimize bone metastases management for each patient in harmony with oncology program.\n\nThe assessment of the fracture risk of bone metastasis remains fairly empirical and is based on simple radiography. The Mirel's score for long bones is focused on the extent of cortical defect caused by bone metastasis to identify high-risk patients at risk of fracture during surgery. It is old, little used in routine and lacks sensitivity and specificity. The SINS (Spinal Instability Neoplastic Score) score is the reference for vertebrae. Today, most patients with fracture-risk bone metastasis benefit from a lesion-centered CT scan to better characterize its extent and position but the interpretation remains qualitative. Metastases are considered as an air cavity and the mechanical properties of the tumor are not evaluated. However, many other parameters from the CTscan are available such as cortical or trabecular compartment densitometry, cortical thickness, tumor volume, and position of lysis in the bone.\n\nBased on experience acquired by the service in the evaluation of bone mechanical strength on benign bones, the investigator aim at integrating in the numerical simulation the mechanical properties of both bone and tumor, in order to evaluate the mechanical strength of the pathological bone using a numerical simulation model (finite element analysis-FEA).\n\nMEKANOS will enroll patients with bone metastases of breast, lung, kidney, thyroid or bladder cancer and myeloma lesions affecting the vertebrae or the upper end of the femur.\n\nThe resistance obtained will be compared to that of an intact bone. The best predictive parameters of mechanical strength (position of lysis, tumor nature, and bone architecture) will be then determined. Finally, the added value of this technique in relation to historical fragility scores (Mirel's and SINS scores) will be assessed.\n\nThe ultimate goal is to provide tools to assess fracture risk and improve the preventive management of bone metastases in harmony with the referring oncologist",[222,223,224],"Metastases to Bone","Metastatic Breast Cancer","Metastatic NSCLC",[226,227,228,229],"osteolytic secondary tumoral lesion","femur","vertebrae","qCT routine imagery","2024-12-11",{"date":232,"type":233},"2024-12-16","ACTUAL",{"date":235,"type":233},"2019-11-28",{"date":237,"type":218},"2026-11-28",{"name":5,"class":6},12]