[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605552":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":37,"locations":42,"responsibleParty":44,"collaborators":42,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":49,"sex":55,"minAge":56,"maxAge":42,"enrollmentInfo":57,"targetDuration":42,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":76,"whyStopped":42,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":42},{"fullName":5,"class":6},"Indiana University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Twin-Specific Growth Chart Group","EXPERIMENTAL","Participants in this arm will receive prenatal ultrasound assessments interpreted using a twin-specific growth chart for estimated fetal weight and biometry. Clinical decisions and perinatal risk assessments will be guided based on twin-specific percentiles.",[13],"Other: Twin-Specific Growth Chart Interpretation",{"label":15,"type":16,"description":17,"interventionNames":18},"Singleton-Based Growth Chart Group","ACTIVE_COMPARATOR","Participants in this arm will receive prenatal ultrasound assessments interpreted using a singleton-based growth chart for estimated fetal weight and biometry. Clinical decisions and perinatal risk assessments will be based on singleton percentiles, which represent standard practice in many settings.",[19],"Other: Singleton-Based Growth Chart Interpretation",[21,27],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Twin-Specific Growth Chart Interpretation","Participants in this arm will have their fetal growth assessed using twin-specific growth charts. These charts account for twin gestation norms and may influence clinical decision-making regarding growth restriction and perinatal management. The intervention does not involve any direct physical procedure or device but rather a change in the interpretation framework of routinely collected ultrasound data.",[9],[26],"TWiST-Twin Chart",{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Singleton-Based Growth Chart Interpretation","Participants in this arm will have their fetal growth assessed using singleton-based growth charts. These charts are commonly used in standard practice but may overestimate growth restriction in twin pregnancies. The intervention does not involve any direct physical procedure or device but alters the interpretation framework for standard prenatal ultrasound findings.",[15],[32],"TWiST-Singleton Chart",[34],{"name":35,"affiliation":5,"role":36},"Hiba Mustafa, MD","PRINCIPAL_INVESTIGATOR",[38],{"name":39,"role":40,"phone":41,"phoneExt":42,"email":43},"Emrah Aydin, MD, PhD, MBA, MSc","CONTACT","5132202779",null,"eaydin@iu.edu",{"type":36,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":42,"oldOrganization":42},"Hiba Mustafa","Assistant Professor","100605552","twins-with-specific-vs-traditional-fetal-growth-charts-100605552",false,"NCT07164001","Twins With Specific vs. Traditional Fetal Growth Charts","Twins With Specific vs. Traditional Fetal Growth Charts (TWiST): A Randomized Controlled Trial","TWiST","Inclusion Criteria:\n\n* Pregnant individuals with a twin pregnancy of at least 18 weeks gestation.\n* Willing and able to provide informed consent.\n* Planning to deliver at a participating center.\n\nExclusion Criteria:\n\n* Major fetal anomalies or known aneuploidy.\n* Significant maternal medical conditions that might confound study outcomes.\n* Inability to comply with study procedures.","FEMALE","18 Years",{"count":58,"type":59},150,"ESTIMATED","INTERVENTIONAL",[62],"NA","This study aims to compare how well two different types of fetal growth charts work in tracking the growth of twins during pregnancy. These charts help doctors decide if a fetus is growing normally. One type is commonly used for all pregnancies, while the other is specially designed for twin pregnancies. The study will enroll pregnant individuals carrying twins. Participants will be randomly assigned to have their care guided by either the traditional chart or the twin-specific chart. Researchers will compare outcomes such as birth weight, timing of delivery, and newborn health. The goal is to find out if using twin-specific charts can improve care and reduce unnecessary interventions.",[65],"Twin Pregnancy",[67,68,69,70,71,72,73,74,75],"Twin-Specific Growth Chart","Singleton-Based Growth Chart","Fetal Biometry","Small for Gestational Age","Growth Assessment","Perinatal Outcomes","Randomized Controlled Trial","Prenatal Ultrasound","Twin Gestation","NOT_YET_RECRUITING","2025-09-09",{"date":79,"type":80},"2025-09-15","ACTUAL",{"date":82,"type":59},"2026-01-01",{"date":84,"type":59},"2030-01-28",{"name":5,"class":6}]