[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100417293":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":41,"locations":47,"responsibleParty":63,"collaborators":66,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":45,"enrollmentInfo":81,"targetDuration":45,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":50,"whyStopped":45,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"University of Geneva, Switzerland","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ZR-TiB","EXPERIMENTAL","Monolithic zirconia screw retained implant-supported cantilever reconstruction supported by titanium base abutments, in a full digital workflow (ZR)",[13],"Device: Monolithic zirconia screw retained implant-supported cantilever reconstruction supported by titanium base abutments, in a full digital workflow (ZR-TiB)",{"label":15,"type":16,"description":17,"interventionNames":18},"PFM-GA","ACTIVE_COMPARATOR","Porcelain fused-to metal screw retained implant-supported cantilever reconstruction supported by a gold-abutment, in a conventional workflow (PFM)",[19],"Device: porcelain fused-to metal screw retained implant-supported cantilever reconstruction supported by a gold-abutment, in a conventional workflow (PFM-GA)",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Monolithic zirconia screw retained implant-supported cantilever reconstruction supported by titanium base abutments, in a full digital workflow (ZR-TiB)","In group ZR-TiB the implant impressions will be taken using an intra-oral scanner and the respective scanbody. The restorations will be manufactured by means of CAD\u002FCAM procedures using monolithic zirconia. For sufficient aesthetics, the zirconia restorations can be manually veneered with veneering ceramic only at the buccal surface, while the occlusal surface will remain monolithic and will be high-gloss polished. The zirconia restorations will be extra-orally cemented onto titanium base abutments (Straumann® Variobase® for crown, Straumann AG), correctly polished and delivered to the patient, by screw-retention onto the implant.",[9],[27],"Straumann® Variobase® for crown",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"porcelain fused-to metal screw retained implant-supported cantilever reconstruction supported by a gold-abutment, in a conventional workflow (PFM-GA)","In group PFM-GA implant impression will be taken using a polyvinyl siloxane or polyether impression material in a conventional manner with the use of stock trays and corresponding impression copings. The framework will be manufactured by the lost wax-technique using a gold-abutment (Straumann® Gold abutment for crown, Straumann AG) and a gold-alloy. All metal frameworks will be manually veneered with veneering ceramic, polished and glazed, and delivered to the patient, by screw-retention onto the implant.",[15],[33],"Straumann® Gold abutment for crown",[35,38],{"name":36,"affiliation":5,"role":37},"João Pitta, Dr","PRINCIPAL_INVESTIGATOR",{"name":39,"affiliation":5,"role":40},"Irena Sailer, Prof","STUDY_CHAIR",[42],{"name":36,"role":43,"phone":44,"phoneExt":45,"email":46},"CONTACT","+41223794088",null,"joao.pitta@unige.ch",[48],{"facility":49,"status":50,"city":51,"state":45,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"University of Geneva","RECRUITING","Geneva","1211","Switzerland","CH",{"type":56,"coordinates":57},"Point",[58,59],6.14569,46.20222,{"lat":59,"lon":58},[62],{"name":36,"role":43,"phone":45,"phoneExt":45,"email":45},{"type":37,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":45,"oldOrganization":45},"João Pitta","Principal Investigator, Research and Teaching Fellow",[67],{"name":68,"class":69},"ITI Foundation","INDUSTRY","100417293","two-unit-cantilever-implant-prostheses-made-of-monolithic-zirconia-or-pfm-100417293",false,"NCT04713800","Two-unit Cantilever Implant Prostheses Made of Monolithic Zirconia or PFM","Randomized Controlled Clinical Trial of Two-unit Cantilever Implant Prostheses Made of Monolithic Zirconia on Titanium Base Abutments or Porcelain-fused to Metal on Gold Abutments","Cantilever","Inclusion Criteria:\n\n* Minimal age of 22 years old.\n* No general medical condition which represents a contraindication to implant treatment\n* Good oral hygiene (PII ≤ 20%), and healthy periodontal tissues (BOP≤ 20%)\n* Two adjacent-teeth gap in posterior maxilla or mandible arch (first premolar, second premolar, first molar, second molar) with an osseointegrated regular or wide-diameter bone-level implant in a prosthetically correct position to allow occlusal screw-retention. Free-end edentulous gaps can also be included\n* Presence of antagonist occlusal units\n\nExclusion Criteria:\n\n* Severe bruxism or clenching habits\n* Patients with inadequate oral hygiene or persistent intraoral infection\n* Women who are pregnant or breast feeding at the day of inclusion\n* Smokers exceeding 15 cigarettes \u002F day, or equivalent; patients chewing tobacco\n* Unable or unwilling to cooperate for the trial period\n* Estimated cantilever crown mesial-distal length \\> 10 mm\n* Estimated implant crown height (from implant platform to occlusal contact points) \\> 15 mm",true,"ALL","22 Years",{"count":82,"type":83},38,"ESTIMATED","INTERVENTIONAL",[86],"NA","The aim of is to compare the survival rate and technical outcomes of cantilever implant-supported fixed denture prosthetics (cFDPs) made either out of monolithic zirconia bonded to a titanium base in a digital workflow, or porcelain fused-to metal using a gold abutment in a conventional workflow. In addition, biological outcomes, wear patterns, PROMs and time efficiency will be recorded. The null hypothesis is: the reconstruction type does not influence the survival rate and technical outcomes of 2-unit implant-supported cFDP.",[89,90],"Jaw, Edentulous, Partially","Missing Teeth",[92,76,93,94,95,96,97],"Dental Implants","Titanium base","Dental abutment","Fixed dental prosthesis","Monolithic zirconia","Porcelain fused to metal","2022-11-21",{"date":100,"type":101},"2022-11-23","ACTUAL",{"date":103,"type":101},"2021-07-28",{"date":105,"type":83},"2027-07",{"name":5,"class":6},1]