[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100586473":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":29,"locations":38,"responsibleParty":55,"collaborators":57,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":63,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":12,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":12,"overallStatus":40,"whyStopped":12,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"University of Chicago","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Untreated","NO_INTERVENTION","No treatment for OSA",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Treated: Continuous positive airway pressure (CPAP) treatment","ACTIVE_COMPARATOR","Treatment for OSA by CPAP",[18],"Device: Continuous positive airway pressure (CPAP)",[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":12},"DEVICE","Continuous positive airway pressure (CPAP)","All-night CPAP will be applied with bedtimes 23:00h to 7:00h.",[14],[26],{"name":27,"affiliation":5,"role":28},"Esra Tasali, MD","PRINCIPAL_INVESTIGATOR",[30,34],{"name":27,"role":31,"phone":32,"phoneExt":12,"email":33},"CONTACT","7738342663","etasali@bsd.uchicago.edu",{"name":35,"role":31,"phone":36,"phoneExt":12,"email":37},"Becky Tucker","7737022348","tuckerb@bsd.uchicago.edu",[39],{"facility":5,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RECRUITING","Chicago","Illinois","60637","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-87.65005,41.85003,{"lat":50,"lon":49},[53],{"name":35,"role":31,"phone":54,"phoneExt":12,"email":37},"773-702-2348",{"type":56,"investigatorFullName":12,"investigatorTitle":12,"investigatorAffiliation":12,"oldNameTitle":12,"oldOrganization":12},"SPONSOR",[58],{"name":59,"class":60},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100586473","type-1-diabetes-and-obstructive-sleep-apnea-100586473",false,"NCT06915831","Type 1 Diabetes and Obstructive Sleep Apnea","Obstructive Sleep Apnea and Glycemic Dysregulation in Adults With Type 1 Diabetes","T1D and OSA","Inclusion Criteria:\n\n* Age: 18 to 50 years old\n* Type 1 Diabetes on insulin pump therapy and using a CGM device with an GMI (glucose management indicator) between 5.5 and 8.5% with hemoglobin in the normal range at screening\n* OSA by home sleep apnea test\n\nExclusion Criteria:\n\n* Regular and adherent CPAP use per clinical guidelines\n* Requiring oxygen or advanced positive airway pressure modalities during sleep\n* Having a 'fall-asleep' or 'near miss' accident in the past 6-months\n* Shift work\n* Severe hypoglycemia (≥1 episode in the past 3 months or diagnosis of hypoglycemic unawareness)\n* ≥1 trip to emergency room for poor glucose management in the past 6 months\n* Proliferative retinopathy\n* Fasting triglycerides \\>400mg\u002FdL,\n* Liver transaminases \\>2 times upper limit of normal,\n* Renal transplantation or serum creatinine \\>1.5 mg\u002FdL\n* Anemia (hemoglobin \\\u003C13.0g\u002FdL in men or \\\u003C11.6g\u002FdL in women)\n* Acute coronary syndrome or stroke past 6 months\n* Severe hypertension (blood pressure\\>180\u002F105 mmHg)\n* Any other significant health condition: unstable angina, heart failure requiring hospitalization in the past 6 months, significant heart block or arrhythmias, NYHA Class\\>2, pulmonary disease with dependence on oxygen or daily use of bronchodilators, active or chronic infection, thyroid disease and other endocrine disorders (e.g. Cushing syndrome, acromegaly)\n* Recent major surgery\n* Major psychiatric disorder\n* Subjects will also be excluded if taking medications that can confound metabolic assessments including systemic glucocorticoids, antipsychotics, thiazide diuretics, beta-blockers, daily use of aminophylline or theophylline, or use of any immunosuppressant.\n* Currently pregnant or trying to get pregnant or nursing\n* Smoking, alcohol or illegal drug abuse","ALL","18 Years","50 Years",{"count":73,"type":74},40,"ESTIMATED","INTERVENTIONAL",[77],"NA","The purpose of the study is to investigate the role of sleep apnea in glycemic dysregulation in adults with Type 1 diabetes.",[80,81],"Sleep Apnea, Obstructive","Type 1 Diabetes (T1D)","2026-01-15",{"date":84,"type":85},"2026-01-20","ACTUAL",{"date":87,"type":85},"2025-11-10",{"date":89,"type":74},"2029-08-31",{"name":5,"class":6},1]