[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100559167":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":21,"centralContacts":36,"locations":46,"responsibleParty":414,"collaborators":417,"id":436,"slug":437,"hasResults":438,"nctId":439,"briefTitle":440,"officialTitle":440,"acronym":441,"eligibilityCriteria":442,"healthyVolunteers":438,"sex":443,"minAge":10,"maxAge":444,"enrollmentInfo":445,"targetDuration":448,"studyType":449,"phases":10,"briefSummary":450,"conditions":451,"keywords":10,"overallStatus":49,"whyStopped":10,"lastUpdateSubmitDate":453,"lastUpdatePostDateStruct":454,"startDateStruct":457,"completionDateStruct":459,"leadSponsor":461,"locationsCount":462},{"fullName":5,"class":6},"The Hospital for Sick Children","OTHER",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"Cohort 1 - Biologic Basis of JIA",null,"The objectives for this group are to help researchers look at childhood arthritis and determine which management approach is best for each individual child.\n\nTo be eligible for this group:\n\nParticipant must be ≤ 18 years of age at time of study enrollment. Participant is suspected to have JIA. Participant has not received any treatment other than non-steroidal anti-inflammatory drugs, such as acetaminophen.",{"label":13,"type":10,"description":14,"interventionNames":10},"Cohort 2 - Start Biologics","The objectives for this group are to help researchers develop a tool to predict response to therapy.\n\nTo be eligible for this group:\n\nParticipant ≤ 18 years of age at time of study enrollment. Participant has been diagnosed with JIA and arthritis is active. Participant will be starting, re-starting or switching to a new biologic therapy.",{"label":16,"type":10,"description":17,"interventionNames":10},"Cohort 3 - Stop Biologics","The objectives for this group are to help researchers develop a tool to predict who will remain in remission after discontinuing therapy.\n\nTo be eligible for this group:\n\nParticipant ≤ 18 years of age at time of study enrollment. Participant has been diagnosed with JIA and arthritis is inactive. Participant will be stopping or tapering biologic therapy.",{"label":19,"type":10,"description":20,"interventionNames":10},"Cohort 4: Extreme Phenotypes","The objective for this group is new gene discovery and drug target identification.\n\nTo be eligible for this group:\n\nThere is high suspicion of genetic contribution. Participants are severely affected with difficult to control arthritis or systemic disease.\n\nThere is unexplained systemic inflammation with arthritis\u002Farthralgia as a part of manifestations",[22,26,29,32,34],{"name":23,"affiliation":24,"role":25},"Rae SM Yeung, MD, PhD, FRCPC","The Hospital for Sick Children (SickKids), University of Toronto","PRINCIPAL_INVESTIGATOR",{"name":27,"affiliation":28,"role":25},"Nico Wulffraat, MD, PhD","Wilhelmina Children's Hospital, University Medical Center Utrecht",{"name":30,"affiliation":31,"role":25},"Susa Benseler, MD, PhD","Alberta Children's Hospital and Cumming School of Medicine, University of Calgary",{"name":33,"affiliation":28,"role":25},"Joost Swart, MD, PhD",{"name":35,"affiliation":28,"role":25},"Bas Vastert, MD, PhD",[37,43],{"name":38,"role":39,"phone":40,"phoneExt":41,"email":42},"Alexander Mosoiu","CONTACT","416-813-7654","302495","alexander.mosiu@sickkids.ca",{"name":44,"role":39,"phone":40,"phoneExt":41,"email":45},"Amy Xu","amy.xu@sickkids.ca",[47,79,97,124,137,150,169,186,202,223,256,277,296,313,326,345,360,376,390],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Alberta Children's Hospital - University of Calgary","RECRUITING","Calgary","Alberta","T3B 6A8","Canada","CA",{"type":56,"coordinates":57},"Point",[58,59],-114.08529,51.05011,{"lat":59,"lon":58},[62,64,67,69,71,73,75,77],{"name":63,"role":25,"phone":10,"phoneExt":10,"email":10},"Paivi Miettunen, MD",{"name":65,"role":66,"phone":10,"phoneExt":10,"email":10},"Nicole Johnson, MD","SUB_INVESTIGATOR",{"name":68,"role":66,"phone":10,"phoneExt":10,"email":10},"Muhammed Dhalla, MD",{"name":70,"role":66,"phone":10,"phoneExt":10,"email":10},"Heinrike Schmeling, MD",{"name":72,"role":66,"phone":10,"phoneExt":10,"email":10},"Marinka Twilt, MD",{"name":74,"role":66,"phone":10,"phoneExt":10,"email":10},"Rebeka Stevenson, MD",{"name":76,"role":66,"phone":10,"phoneExt":10,"email":10},"Susanne Benseler, MD",{"name":78,"role":66,"phone":10,"phoneExt":10,"email":10},"Deborah Marshall, PhD",{"facility":80,"status":49,"city":81,"state":51,"zip":82,"country":53,"countryCode":54,"cosmosGeoPoint":83,"geoPoint":87,"contacts":88},"Stollery Children's Hospital","Edmonton","T6G 2B7",{"type":56,"coordinates":84},[85,86],-113.46871,53.55014,{"lat":86,"lon":85},[89,91,93,95],{"name":90,"role":25,"phone":10,"phoneExt":10,"email":10},"Dax G Rumsey, MD, MSc, FRCP(C)",{"name":92,"role":66,"phone":10,"phoneExt":10,"email":10},"Daniah Basodan, MBBS, FRCP(C)",{"name":94,"role":66,"phone":10,"phoneExt":10,"email":10},"Lillian Lim, MD, MPH, FRCP(C)",{"name":96,"role":66,"phone":10,"phoneExt":10,"email":10},"Tara McGrath, MD",{"facility":98,"status":49,"city":99,"state":100,"zip":101,"country":53,"countryCode":54,"cosmosGeoPoint":102,"geoPoint":106,"contacts":107},"BC Children's Hospital","Vancouver","British Columbia","V6H 3N1",{"type":56,"coordinates":103},[104,105],-123.11934,49.24966,{"lat":105,"lon":104},[108,110,112,114,116,118,120,122],{"name":109,"role":25,"phone":10,"phoneExt":10,"email":10},"Lori Tucker, MD, FRCPC",{"name":111,"role":66,"phone":10,"phoneExt":10,"email":10},"Andrea Human, MD, MScHQ, FRCPC",{"name":113,"role":66,"phone":10,"phoneExt":10,"email":10},"David Cabral, MBBS, FRCPC",{"name":115,"role":66,"phone":10,"phoneExt":10,"email":10},"Jaime Guzman, MD, MSc, FRCPC",{"name":117,"role":66,"phone":10,"phoneExt":10,"email":10},"Kim Morishita, MD, MHSc, FRCPC",{"name":119,"role":66,"phone":10,"phoneExt":10,"email":10},"Kristin Houghton, MD, MSc, FRCPC, Dip Sports Med",{"name":121,"role":66,"phone":10,"phoneExt":10,"email":10},"Herman Tam, MD, FRCPC",{"name":123,"role":66,"phone":10,"phoneExt":10,"email":10},"Mercedes Chan, MBBS, MHPE, FRCPC",{"facility":125,"status":49,"city":126,"state":127,"zip":128,"country":53,"countryCode":54,"cosmosGeoPoint":129,"geoPoint":133,"contacts":134},"Children's Hospital Health Science Centre Winnipeg","Winnipeg","Manitoba","R3A 1R9",{"type":56,"coordinates":130},[131,132],-97.14704,49.8844,{"lat":132,"lon":131},[135],{"name":136,"role":25,"phone":10,"phoneExt":10,"email":10},"Lily Lim, MBBS, MRCPCH, FRCPC, PhD",{"facility":138,"status":49,"city":139,"state":140,"zip":141,"country":53,"countryCode":54,"cosmosGeoPoint":142,"geoPoint":146,"contacts":147},"Janeway Children's Hospital and Rehabilitation Centre","St. John's","Newfoundland and Labrador","A1B 3V6",{"type":56,"coordinates":143},[144,145],-52.70931,47.56494,{"lat":145,"lon":144},[148],{"name":149,"role":25,"phone":10,"phoneExt":10,"email":10},"Paul Dancey, MD, FRCPC",{"facility":151,"status":49,"city":152,"state":153,"zip":154,"country":53,"countryCode":54,"cosmosGeoPoint":155,"geoPoint":159,"contacts":160},"IWK Health Centre","Halifax","Nova Scotia","B3K 6R8",{"type":56,"coordinates":156},[157,158],-63.57688,44.64269,{"lat":158,"lon":157},[161,163,165,167],{"name":162,"role":25,"phone":10,"phoneExt":10,"email":10},"Adam Huber, MD",{"name":164,"role":66,"phone":10,"phoneExt":10,"email":10},"Bianca Lang, MD",{"name":166,"role":66,"phone":10,"phoneExt":10,"email":10},"Elizabeth Stringer, MD",{"name":168,"role":66,"phone":10,"phoneExt":10,"email":10},"Chelsea DeCoste, MD",{"facility":170,"status":49,"city":171,"state":172,"zip":173,"country":53,"countryCode":54,"cosmosGeoPoint":174,"geoPoint":178,"contacts":179},"McMaster Children's Hospital","Hamilton","Ontario","L8N 3Z5",{"type":56,"coordinates":175},[176,177],-79.84963,43.25011,{"lat":177,"lon":176},[180,182,184],{"name":181,"role":25,"phone":10,"phoneExt":10,"email":10},"Michelle Batthish, MD",{"name":183,"role":66,"phone":10,"phoneExt":10,"email":10},"Tania Cellucci",{"name":185,"role":66,"phone":10,"phoneExt":10,"email":10},"Liane Heale",{"facility":187,"status":49,"city":188,"state":172,"zip":189,"country":53,"countryCode":54,"cosmosGeoPoint":190,"geoPoint":194,"contacts":195},"Children's Hospital, London Health Sciences Centre","London","N6A 5W9",{"type":56,"coordinates":191},[192,193],-81.23304,42.98339,{"lat":193,"lon":192},[196,198,200],{"name":197,"role":25,"phone":10,"phoneExt":10,"email":10},"Roberta Berard, MD",{"name":199,"role":66,"phone":10,"phoneExt":10,"email":10},"Jonathan Park, MD",{"name":201,"role":66,"phone":10,"phoneExt":10,"email":10},"Erkan Demirkaya, MD",{"facility":203,"status":49,"city":204,"state":172,"zip":205,"country":53,"countryCode":54,"cosmosGeoPoint":206,"geoPoint":210,"contacts":211},"Children's Hospital of Eastern Ontario","Ottawa","K1H 8L1",{"type":56,"coordinates":207},[208,209],-75.69812,45.41117,{"lat":209,"lon":208},[212,215,217,219,221],{"name":213,"role":39,"phone":10,"phoneExt":10,"email":214},"Michele Gibbon","mgibbon@cheo.on.ca",{"name":216,"role":25,"phone":10,"phoneExt":10,"email":10},"Ciaran Duffy, MB",{"name":218,"role":66,"phone":10,"phoneExt":10,"email":10},"Roman Jurencak, MD",{"name":220,"role":66,"phone":10,"phoneExt":10,"email":10},"Nadia Luca, MD",{"name":222,"role":66,"phone":10,"phoneExt":10,"email":10},"Tala El Tal, MD",{"facility":5,"status":49,"city":224,"state":172,"zip":225,"country":53,"countryCode":54,"cosmosGeoPoint":226,"geoPoint":230,"contacts":231},"Toronto","M5G 1E8",{"type":56,"coordinates":227},[228,229],-79.39864,43.70643,{"lat":229,"lon":228},[232,234,236,238,240,242,244,246,248,250,252,254],{"name":233,"role":25,"phone":10,"phoneExt":10,"email":10},"Shirley Tse, MD",{"name":235,"role":25,"phone":10,"phoneExt":10,"email":10},"Deborah Levy, MD",{"name":237,"role":66,"phone":10,"phoneExt":10,"email":10},"Ronald Laxer, MDCM",{"name":239,"role":66,"phone":10,"phoneExt":10,"email":10},"Brian Feldman, MD",{"name":241,"role":66,"phone":10,"phoneExt":10,"email":10},"Dilan Dissanayake, MD",{"name":243,"role":66,"phone":10,"phoneExt":10,"email":10},"Elizaveta Limenis, MD",{"name":245,"role":66,"phone":10,"phoneExt":10,"email":10},"Ruud Verstegen, MD",{"name":247,"role":66,"phone":10,"phoneExt":10,"email":10},"Lynn Spiegel, MD",{"name":249,"role":66,"phone":10,"phoneExt":10,"email":10},"Evelyn Rozenblyum, MD",{"name":251,"role":66,"phone":10,"phoneExt":10,"email":10},"Jennifer JY Lee, MD",{"name":253,"role":66,"phone":10,"phoneExt":10,"email":10},"Alisa Rachlis, MD",{"name":255,"role":66,"phone":10,"phoneExt":10,"email":10},"Rae Yeung, MD",{"facility":257,"status":49,"city":258,"state":259,"zip":260,"country":53,"countryCode":54,"cosmosGeoPoint":261,"geoPoint":265,"contacts":266},"Montréal Children's Hospital","Montreal","Quebec","H4A 3J1",{"type":56,"coordinates":262},[263,264],-73.58781,45.50884,{"lat":264,"lon":263},[267,269,271,273,275],{"name":268,"role":25,"phone":10,"phoneExt":10,"email":10},"Claire LeBlanc, M.A, MD, FRCPC, Dip Sport Med",{"name":270,"role":66,"phone":10,"phoneExt":10,"email":10},"Gaelle Chedeville, MsC, MD",{"name":272,"role":66,"phone":10,"phoneExt":10,"email":10},"Rosie Scuccimarri, MD",{"name":274,"role":66,"phone":10,"phoneExt":10,"email":10},"Sarah Campillo, MD, FRCPC",{"name":276,"role":66,"phone":10,"phoneExt":10,"email":10},"Piya Lahiry, M.SC, PHD, MD, FRCPC",{"facility":278,"status":49,"city":279,"state":280,"zip":281,"country":53,"countryCode":54,"cosmosGeoPoint":282,"geoPoint":286,"contacts":287},"University of Saskatchewan","Saskatoon","Saskatchewan","S7N 5A2",{"type":56,"coordinates":283},[284,285],-106.66892,52.13238,{"lat":285,"lon":284},[288,290,292,294],{"name":289,"role":25,"phone":10,"phoneExt":10,"email":10},"Alan Rosenberg",{"name":291,"role":66,"phone":10,"phoneExt":10,"email":10},"Mehul Jariwala",{"name":293,"role":66,"phone":10,"phoneExt":10,"email":10},"Tristan Kerr",{"name":295,"role":66,"phone":10,"phoneExt":10,"email":10},"Kate Neufeld",{"facility":297,"status":49,"city":298,"state":299,"zip":300,"country":301,"countryCode":302,"cosmosGeoPoint":303,"geoPoint":307,"contacts":308},"Amalia Children's Hospital, Radboudumc","Nijmegen","Gelderland","6525 GA","Netherlands","NL",{"type":56,"coordinates":304},[305,306],5.85278,51.8425,{"lat":306,"lon":305},[309,311],{"name":310,"role":25,"phone":10,"phoneExt":10,"email":10},"Ellen Schatorjé, MD, PhD",{"name":312,"role":66,"phone":10,"phoneExt":10,"email":10},"Esther Hoppenreijs, MD",{"facility":314,"status":49,"city":315,"state":316,"zip":317,"country":301,"countryCode":302,"cosmosGeoPoint":318,"geoPoint":322,"contacts":323},"Sint Maartenskinderkliniek","Boxmeer","North Brabant","6574 NA",{"type":56,"coordinates":319},[320,321],5.94722,51.64667,{"lat":321,"lon":320},[324,325],{"name":310,"role":66,"phone":10,"phoneExt":10,"email":10},{"name":312,"role":25,"phone":10,"phoneExt":10,"email":10},{"facility":327,"status":49,"city":328,"state":329,"zip":330,"country":301,"countryCode":302,"cosmosGeoPoint":331,"geoPoint":335,"contacts":336},"Emma Children's Hospital, Amsterdam UMC","Amsterdam","North Holland","1105 AZ",{"type":56,"coordinates":332},[333,334],4.88969,52.37403,{"lat":334,"lon":333},[337,339,341,343],{"name":338,"role":66,"phone":10,"phoneExt":10,"email":10},"Dieneke Schonenberg, MD, PhD",{"name":340,"role":66,"phone":10,"phoneExt":10,"email":10},"Mariken Gruppen, MD",{"name":342,"role":25,"phone":10,"phoneExt":10,"email":10},"Merlijn van den Berg, MD, PhD",{"name":344,"role":66,"phone":10,"phoneExt":10,"email":10},"Giske Biesbroek, MD",{"facility":346,"status":49,"city":347,"state":348,"zip":349,"country":301,"countryCode":302,"cosmosGeoPoint":350,"geoPoint":354,"contacts":355},"Willem-Alexander Children's Hospital, LUMC","Leiden","South Holland","2333 ZA",{"type":56,"coordinates":351},[352,353],4.49306,52.15833,{"lat":353,"lon":352},[356,358],{"name":357,"role":66,"phone":10,"phoneExt":10,"email":10},"Danielle Brinkman, MD",{"name":359,"role":25,"phone":10,"phoneExt":10,"email":10},"Petra Hissink Muller, MD",{"facility":361,"status":49,"city":362,"state":348,"zip":363,"country":301,"countryCode":302,"cosmosGeoPoint":364,"geoPoint":368,"contacts":369},"Sophia Children's Hospital, EMC","Rotterdam","3015 CN",{"type":56,"coordinates":365},[366,367],4.47917,51.9225,{"lat":367,"lon":366},[370,372,374],{"name":371,"role":66,"phone":10,"phoneExt":10,"email":10},"Philomine van Pelt, MD, PhD",{"name":373,"role":66,"phone":10,"phoneExt":10,"email":10},"Marleen Verkaaik, MD",{"name":375,"role":25,"phone":10,"phoneExt":10,"email":10},"Sylvia Kamphuis, MD, PhD",{"facility":377,"status":49,"city":378,"state":10,"zip":379,"country":301,"countryCode":302,"cosmosGeoPoint":380,"geoPoint":384,"contacts":385},"Beatrix Children's Hospital, UMCG","Groningen","9713 GZ",{"type":56,"coordinates":381},[382,383],6.56667,53.21917,{"lat":383,"lon":382},[386,388],{"name":387,"role":66,"phone":10,"phoneExt":10,"email":10},"Elisabeth Legger, MD",{"name":389,"role":25,"phone":10,"phoneExt":10,"email":10},"Wineke Armbrust, MD, PhD",{"facility":391,"status":49,"city":392,"state":10,"zip":393,"country":301,"countryCode":302,"cosmosGeoPoint":394,"geoPoint":398,"contacts":399},"Wilhelmina Children's Hospital, UMCU","Utrecht","3584 EA",{"type":56,"coordinates":395},[396,397],5.12222,52.09083,{"lat":397,"lon":396},[400,403,405,406,408,410,411,413],{"name":401,"role":39,"phone":10,"phoneExt":10,"email":402},"Regina de Geus","r.degeus@umcutrecht.nl",{"name":404,"role":66,"phone":10,"phoneExt":10,"email":10},"Annet van Royen-Kerkhof, MD, PhD",{"name":35,"role":25,"phone":10,"phoneExt":10,"email":10},{"name":407,"role":66,"phone":10,"phoneExt":10,"email":10},"Berent Prakken, MD, PhD",{"name":409,"role":66,"phone":10,"phoneExt":10,"email":10},"Erika VanNieuwenhove, MD, PhD",{"name":33,"role":25,"phone":10,"phoneExt":10,"email":10},{"name":412,"role":66,"phone":10,"phoneExt":10,"email":10},"Marc Jansen, MD, PhD",{"name":27,"role":66,"phone":10,"phoneExt":10,"email":10},{"type":25,"investigatorFullName":415,"investigatorTitle":416,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Rae Yeung","Professor, Staff Physician and Senior Scientist",[418,421,423,425,427,430,432,434],{"name":419,"class":420},"Canadian Institutes of Health Research (CIHR)","OTHER_GOV",{"name":422,"class":6},"Genome Canada",{"name":424,"class":6},"Genome Alberta",{"name":426,"class":6},"The Arthritis Society, Canada",{"name":428,"class":429},"ReumaNederland","UNKNOWN",{"name":431,"class":6},"ZonMw: The Netherlands Organisation for Health Research and Development",{"name":433,"class":6},"Alberta Children's Hospital",{"name":435,"class":429},"Ontario Genomics","100559167","ucan-can-du-canada-netherlands-personalized-medicine-network-in-childhood-arthritis-and-rheumatic-disease-100559167",false,"NCT06560606","UCAN CAN-DU: Canada-Netherlands Personalized Medicine Network in Childhood Arthritis and Rheumatic Disease","UCAN CAN-DU","Inclusion Criteria:\n\nCohort 1: - Biologic Basis of JIA\n\n* ≤18 years\\*\n* Active objective arthritis suspected to be JIA or diagnosed with JIA within 6 months of enrolment\n* Treatment naïve except for NSAIDs, allowed to have received NSAIDS within 6 months of diagnosis\n\nCohort 2 - Start Biologics\n\n* JIA diagnosis as per ILAR criteria (all subtypes)\n* ≤18 years\\*\n* Active arthritis\n* For sJIA, active disease not necessarily with arthritis.\n* Time of start, restart or switch biologic therapy: e.g. failure, insufficient\u002Fpartial response or intolerance\n\nCohort 3 - Stop Biologics\n\n* JIA diagnosis as per ILAR criteria (all subtypes)\n* ≤18 years\\*\n* Inactive disease\n* Discontinuing\u002Ftapering biologics for inactive disease\n\nCohort 4: Extreme Phenotypes\n\n* Unexplained systemic inflammation with arthritis\u002Farthralgia as a part of manifestations\n* High suspicion of genetic contribution\n* Severely affected patients with difficult to control disease (ie failure of multiple biologics)\n\nExclusion Criteria:\n\nCohort 1 :\n\n* Arthritis explained by another diagnosis\n* Joint injections as previous treatment less than 4 weeks prior to enrollment\n\nCohort 2:\n\n* Arthritis explained by any other cause\n* Start on biologics as an indication for uveitis only\n\nCohort 3:\n\n\\- Tapering scheme \\> 12 months to complete biologics stop\n\nCohort 4:\n\n\\- Arthritis explained by another diagnosis","ALL","18 Years",{"count":446,"type":447},4100,"ESTIMATED","2 Years","OBSERVATIONAL","Childhood arthritis is a chronic disabling disease. New medications called biologic therapies are now available to treat arthritis that target key biologic molecules that cause inflammation. Biologic therapies, while very effective in treating arthritis in children, may have serious side effects including infections and potentially cancers, and are very expensive and doctors don't know, which one to choose for which child. The investigators will develop tests that enable them to learn about the biology of each child's arthritis and be able to predict when and which biologic therapy to start and when to stop.",[452],"Juvenile Idiopathic Arthritis","2024-08-16",{"date":455,"type":456},"2024-08-19","ACTUAL",{"date":458,"type":456},"2018-08-24",{"date":460,"type":447},"2027-03-30",{"name":5,"class":6},19]