[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100482912":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":22,"locations":28,"responsibleParty":43,"collaborators":10,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":10,"eligibilityCriteria":50,"healthyVolunteers":47,"sex":51,"minAge":52,"maxAge":10,"enrollmentInfo":53,"targetDuration":10,"studyType":56,"phases":10,"briefSummary":57,"conditions":58,"keywords":10,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":70},{"fullName":5,"class":6},"University of Minnesota","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Group 1",null,"Patients will make one visit to the M Health Clinical Research Unit (CRU) after overnight withdrawal of PD medications (still on-DBS) and undergo motor and cognitive assessments in the following three conditions:\n\n1. clinically-optimized stimulation\n2. model-based stimulation directed towards motor subregions of STN and GPi\n3. model-based stimulation directed towards associative\u002Flimbic subregions of STN\u002FGPi\n\nRandomized to start with condition1 assessment",{"label":13,"type":10,"description":14,"interventionNames":10},"Group 2","Patients will make one visit to the M Health Clinical Research Unit (CRU) after overnight withdrawal of PD medications (still on-DBS) and undergo motor and cognitive assessments in the following three conditions:\n\n1. clinically-optimized stimulation\n2. model-based stimulation directed towards motor subregions of STN and GPi\n3. model-based stimulation directed towards associative\u002Flimbic subregions of STN\u002FGPi\n\nRandomized to start with condition 2 assessment",{"label":16,"type":10,"description":17,"interventionNames":10},"Group 3","Patients will make one visit to the M Health Clinical Research Unit (CRU) after overnight withdrawal of PD medications (still on-DBS) and undergo motor and cognitive assessments in the following three conditions:\n\n1. clinically-optimized stimulation\n2. model-based stimulation directed towards motor subregions of STN and GPi\n3. model-based stimulation directed towards associative\u002Flimbic subregions of STN\u002FGPi\n\nRandomized to start with condition 3 assessment",[19],{"name":20,"affiliation":5,"role":21},"Jerrold Vitek, MD, PhD","PRINCIPAL_INVESTIGATOR",[23],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},"Niecy Beltz","CONTACT","612-626-5711","beltz070@umn.edu",[29],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":10},"University Of Minnesota","RECRUITING","Minneapolis","Minnesota","55455","United States","US",{"type":38,"coordinates":39},"Point",[40,41],-93.26384,44.97997,{"lat":41,"lon":40},{"type":44,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100482912","udall-project-1-aim-4-100482912",false,"NCT05568199","Udall Project 1 Aim 4","Inclusion Criteria:\n\n* Implanted with a DBS system\n* Existing 7T imagery (either done as standard-of-care or done as part of Noam Harel's study, IRB #1210M22183)\n* Diagnosed with idiopathic Parkinson's Disease\n* Minimum age 21 years\n\nExclusion Criteria:\n\n* Other significant neurological disorder, as determined by PI\n* Diagnosis of dementia\n* Pregnant","ALL","21 Years",{"count":54,"type":55},100,"ESTIMATED","OBSERVATIONAL","By defining the strength and direction of connectivity patterns at rest and during movement across the basal ganglia-thalamocortical (BGTC) network we will characterize the role of individual circuits in motor performance and cognitive function, paving the way for future development of optimization algorithms for DBS that take advantage of this understanding.",[59,60],"Parkinsons Disease","Deep Brain Stimulation","2026-04-02",{"date":63,"type":64},"2026-04-08","ACTUAL",{"date":66,"type":64},"2024-03-05",{"date":68,"type":55},"2027-03-01",{"name":5,"class":6},1]