[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100597365":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":53,"collaborators":26,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":58,"sex":64,"minAge":65,"maxAge":26,"enrollmentInfo":66,"targetDuration":26,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":78,"overallStatus":39,"whyStopped":26,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Faculty Hospital Kralovske Vinohrady","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"CSP-CRT arm","EXPERIMENTAL","In this arm, LBBAP CRT will be performed",[13],"Device: LBBAP CRT device implantation",{"label":15,"type":16,"description":17,"interventionNames":18},"BVP-CRT arm","ACTIVE_COMPARATOR","In this arm, BVP CRT will be performed.",[19],"Device: BVP-CRT",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","LBBAP CRT device implantation","Pacing system with a lead implanted in the left bundle branch area will be done.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"BVP-CRT","Implantation of biventricular device",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Karol Curila, MD","CONTACT","+420777869171","karol.curila@fnkv.cz",[38],{"facility":5,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":26,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"RECRUITING","Prague","Česká Republika","10034","Czechia",{"type":45,"coordinates":46},"Point",[47,48],14.42076,50.08804,{"lat":48,"lon":47},[51],{"name":52,"role":34,"phone":35,"phoneExt":26,"email":36},"Karol Curila",{"type":54,"investigatorFullName":52,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","MD, PhD","100597365","uhf-ecg-in-lbbb-and-response-to-crt-prediction-100597365",false,"NCT07057544","UHF ECG in LBBB and Response to CRT Prediction","The Role of Ultra-high-frequency ECG in the Localization of Left Ventricular Conduction Disorders and Prediction of Response to Resynchronization Therapy","UHF BLOCK","Inclusion Criteria:\n\n* HF due to ischemic or non-ischemic cardiomyopathy\n* known coronary angiography\n* NYHA II-IV\n* LVEF ≤40%\n* non-RBBB QRSd lasting \\>130 ms (by automated measurement)\n* proximal LBBB proved by an invasive EP study or non-invasive dyssynchrony assessment in case such a method is confirmed to be non-inferior to an invasive EP study during the project\n\nExclusion Criteria:\n\n* Age ˂18 years\n* heart failure from reversible causes\n* Moderate to severe aortic stenosis\n* pregnancy\n* active myocarditis\n* hypertrophic cardiomyopathy\n* cardiac valve surgery in the last three months\n* myocardial infarction, PCI, or CABG in the last three months\n* severe valvular disease requiring intervention\n* severe atherosclerotic disease of the aorta and\u002For femoral arteries\n* life expectancy ˂1 year\n* known medical condition or contraindication causing potential complications for EP study","ALL","18 Years",{"count":67,"type":68},200,"ESTIMATED","INTERVENTIONAL",[71],"NA","The main objective of the project is to demonstrate that in patients with heart failure and QRS complex of nonRBBB morphology lasting over 130 ms, UHF-ECG can differentiate patients with trueLBBB from IVCD better than existing approaches based on the assessment of QRS complex morphology and duration from 12-lead ECG.\n\nAnother goal of the proposed study is to demonstrate that trueLBBB patients will benefit more from CRT using left bundle branch pacing than from CRT using biventricular pacing.\n\nThe final aim of the project is to demonstrate that the echocardiographic and clinical response in patients with intraventricular conduction disturbance will be dependent on the degree of reduction in ventricular dyssynchrony after CRT.",[74,75,76,77],"Left Bundle Branch Block","Left Bundle Branch Area Pacing","Biventricular Pacing","Intraventricular Conduction Delay",[79,80,81,82,83],"left bundle branch block","resynchronization therapy","intraventricular conduction delay","left bundle branch pacing","biventricular pacing","2025-07-09",{"date":86,"type":87},"2025-07-14","ACTUAL",{"date":89,"type":87},"2024-05-01",{"date":91,"type":68},"2027-12-31",{"name":5,"class":6},1]