[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635698":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":33,"responsibleParty":92,"collaborators":10,"id":94,"slug":95,"hasResults":96,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":100,"eligibilityCriteria":101,"healthyVolunteers":96,"sex":102,"minAge":103,"maxAge":10,"enrollmentInfo":104,"targetDuration":10,"studyType":107,"phases":10,"briefSummary":108,"conditions":109,"keywords":10,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":121},{"fullName":5,"class":6},"Beijing Shijitan Hospital, Capital Medical University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Cerebral autoregulation monitoring cohort",null,"The consecutively enrolled participants undergoing thrombectomy for acute ischemic stroke. Intraoperative cerebral autoregulation will be assessed using near-infrared spectroscopy (NIRS)-based cerebral oxygen saturation monitoring combined with continuous blood pressure monitoring (noninvasive or invasive). This cohort will be used to develop the predictive and validate model for futile recanalization.",[13],"Diagnostic Test: diagnostic accuracy study",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","diagnostic accuracy study","Cerebral autoregulation is assessed intraoperatively during thrombectomy using near-infrared spectroscopy (NIRS)-derived cerebral oxygen saturation combined with continuous noninvasive or invasive arterial blood pressure monitoring. The correlation between cerebral oxygen saturation and arterial blood pressure is analyzed to quantify cerebral autoregulation status. This monitoring is performed as part of routine clinical care and does not constitute an additional research intervention.",[9],[21],{"name":22,"affiliation":5,"role":23},"Shen Li","PRINCIPAL_INVESTIGATOR",[25,30],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Zidong Li","CONTACT","010-63925615","walx592815088@163.com",{"name":22,"role":27,"phone":31,"phoneExt":10,"email":32},"010-63925616","lishen@mail.ccmu.edu.cn",[34,49,63,78],{"facility":5,"status":35,"city":36,"state":37,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"RECRUITING","Beijing","Beijing Municipality","China","CN",{"type":41,"coordinates":42},"Point",[43,44],116.39723,39.9075,{"lat":44,"lon":43},[47,48],{"name":22,"role":27,"phone":31,"phoneExt":10,"email":32},{"name":22,"role":23,"phone":10,"phoneExt":10,"email":10},{"facility":50,"status":35,"city":51,"state":52,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":53,"geoPoint":57,"contacts":58},"The First Affiliated Hospital of Harbin Medical University","Harbin","Heilongjiang",{"type":41,"coordinates":54},[55,56],126.65,45.75,{"lat":56,"lon":55},[59,62],{"name":60,"role":27,"phone":10,"phoneExt":10,"email":61},"Guang Zhang","Zhangguang@hrbmu.edu.cn",{"name":60,"role":23,"phone":10,"phoneExt":10,"email":10},{"facility":64,"status":65,"city":66,"state":67,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"Dalian Municipal Central Hospital","NOT_YET_RECRUITING","Dalian","Liaoning",{"type":41,"coordinates":69},[70,71],121.60222,38.91222,{"lat":71,"lon":70},[74,77],{"name":75,"role":27,"phone":10,"phoneExt":10,"email":76},"Tieping Fan","13841132091@126.com",{"name":75,"role":23,"phone":10,"phoneExt":10,"email":10},{"facility":79,"status":35,"city":80,"state":81,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"Weifang People's Hospital Affiliated to Weifang Medical University","Weifang","Shandong",{"type":41,"coordinates":83},[84,85],119.10194,36.71,{"lat":85,"lon":84},[88,91],{"name":89,"role":27,"phone":10,"phoneExt":10,"email":90},"Weili Li","liweili0536@163.com",{"name":89,"role":23,"phone":10,"phoneExt":10,"email":10},{"type":23,"investigatorFullName":22,"investigatorTitle":93,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Professor","100635698","ultra-early-identification-of-futile-recanalization-after-reperfusion-therapy-in-acute-ischemic-stroke-based-on-cerebral-autoregulation-100635698",false,"NCT07556068","Ultra-early Identification of Futile Recanalization After Reperfusion Therapy in Acute Ischemic Stroke Based on Cerebral Autoregulation","Ultra-early Identification of Futile Recanalization After Reperfusion Therapy in Acute Ischemic Stroke Based on Cerebral Autoregulation Monitoring: a Multicenter, Prospective, Observational Study","CAREFUL-CA","Inclusion Criteria:\n\n1. Age ≥ 18\n2. Clinical signs consistent with acute ischemic stroke with large vessel occlusion in the anterior circulation (intracranial segment of the internal carotid artery, middle cerebral artery M1 segment) demonstrated with CTA\u002FMRA\u002FDSA.\n3. NIHSS score ≥ 6 obtained prior to endovascular treatment.\n4. Modified Rankin Scale ≤ 1 prior to qualifying stroke.\n5. Acute ischemic stroke, undergone endovascular treatment within 24 hours of onset (time of stroke is the last known normal for wake-up stroke or with unknown onset time).with reaching the goal of mTICI grade 2b-3\n6. For patients with symptom onset within 6 hours: ASPECTS ≥ 3; for patients with symptom onset between 6 and 24 hours: age ≤ 80 years and ASPECTS ≥ 3.\n7. Patient\u002FLegally Authorized Representative has signed the Informed Consent Form.\n\nExclusion Criteria:\n\n1. Baseline CT\u002FMRI confirms the presence of multiple vascular territory acute strokes.\n2. Baseline CT\u002FMRI confirms the presence of arterial dissection.\n3. Evidence of intracranial hemorrhage or hemorrhagic transformation before thrombectomy.\n4. Known allergies or intolerances to antiplatelet agents, anticoagulation drugs, iodinated contrast and\u002For anesthetics.\n5. Severe infection (e.g. sepsis) or multiple organ failure.\n6. Known hereditary or acquired hemorrhagic diathesis or coagulation factor deficiency; oral anticoagulant therapy with INR \\> 3; or use of a factor Xa inhibitor within the preceding 48 hours with an abnormal aPTT.\n7. Baseline platelet count \\\u003C 50 × 10\\^9\u002FL.\n8. Blood glucose concentration\\\u003C50 mg\u002FdL (2.7 mmol\u002FL) or \\>400 mg\u002FdL (22.2 mmol\u002FL).\n9. Refractory hypertension that is difficult to control by medication (Defined as persistent systolic blood pressure\\>185 mmHg or diastolic blood pressure\\>110 mmHg).\n10. Severe cardiomyopathy with heart failure (LVEF ≤ 30% or NYHA class IV), acute myocardial infarction, or unstable angina.\n11. Untreated moderate or severe coronary artery stenosis, or previous coronary artery bypass surgery.\n12. Current hemodialysis or peritoneal dialysis; known severe renal insufficiency with estimated glomerular filtration rate \\\u003C 30 mL\u002Fmin or serum creatinine \\> 220 μmol\u002FL (2.5 mg\u002FdL).\n13. Known intracranial aneurysm, and cerebral arteriovenous malformation.\n14. Malignant brain tumor or CNS infection.\n15. Pre-existing neurological or psychiatric disease that would confound the neurological or functional evaluations (e.g., dementia or mental illness)\n16. Female who is pregnant or lactating at time of admission.\n17. Anticipated life expectancy \\\u003C 6 months.\n18. Current participation in another investigational drug or device study.\n19. local skin damage or other conditions that cannot cooperate with electrode sticking.\n20. severe agitation or other conditions affecting data collection.","ALL","18 Years",{"count":105,"type":106},129,"ESTIMATED","OBSERVATIONAL","This multicenter, prospective, observational diagnostic accuracy study enrolls patients undergoing thrombectomy with intraoperative cerebral autoregulation monitoring and follows them up at predefined time points up to 90 days post-enrollment. The study aims to determine whether impaired cerebral autoregulation during thrombectomy can serve as an ultra-early biomarker for predicting futile recanalization in patients with acute ischemic stroke.",[110,111],"Acute Ischemic Stroke","Cerebral Autoregulation","2026-04-30",{"date":114,"type":115},"2026-05-06","ACTUAL",{"date":117,"type":115},"2026-04-20",{"date":119,"type":106},"2026-10-20",{"name":5,"class":6},4]