[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100541982":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":27,"responsibleParty":44,"collaborators":20,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":50,"sex":56,"minAge":57,"maxAge":20,"enrollmentInfo":58,"targetDuration":20,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":30,"whyStopped":20,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"University of Pisa","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Ultrasound group","EXPERIMENTAL","The patients with a clinical diagnosis of oral squamous cell carcinoma will undergo intraoral ultrasonographic scan with a 70 MHz frequency probe to evaluate tumor depth of invasion and thickness",[13],"Device: Ultrasound",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Ultrasound","Ultrasonographic scan with a 70 MHz probe",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Rossana Izzetti, DDS, PhD","CONTACT","+39050993037","rossana.izzetti@unipi.it",[28],{"facility":29,"status":30,"city":31,"state":20,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Università di Pisa","RECRUITING","Pisa","56126","Italy","IT",{"type":36,"coordinates":37},"Point",[38,39],10.4036,43.70853,{"lat":39,"lon":38},[42],{"name":43,"role":24,"phone":25,"phoneExt":20,"email":26},"Rossana Izzetti, DS, PhD",{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","Rossana Izzetti","Researcher at the Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine of the University of Pisa, Principal Investigator","100541982","ultra-high-frequency-intraoral-ultrasonography-of-the-tongue-houston-100541982",false,"NCT06336941","\"Ultra-High Frequency intraOral UltraSonography of the TONgue\" (HOUSTON)","Intraoral Ultra-High Frequency Ultrasound of Oral Soft Tissue Lesions","HOUSTON","Inclusion Criteria:\n\n* Clinical diagnosis of oral squamous cell carcinoma\n* Eligibility for surgical treatment\n* Acceptance to be included in the study\n\nExclusion Criteria:\n\n* Oral lesions other than oral squamous cell carcinoma\n* Pregnant or breastfeeding patients\n* Uncontrolled chronic diseases and\u002For conditions hindering the participation in the study\n* Denial of inclusion in the study","ALL","18 Years",{"count":59,"type":60},400,"ESTIMATED","INTERVENTIONAL",[63],"NA","Oral diseases are currently diagnosed by means of clinical examination and supported by surgical biopsy procedures. In particular, daily oral medicine practice is lacking the use of a routine diagnostic support to the visualization of anatomical structures located beyond the mucosal surface. Considering the growing interest in minimally invasive diagnosis, the possibility of having an imaging technique dedicated to the investigation of oral soft tissues and their alterations may be instrumental to support the clinical diagnosis. Therefore, attempts to introduce conventional ultrasonography (US) to the diagnostic work-up of pathological conditions of the head and neck have been done, exploiting the unique features of this technique in terms of limited invasive- ness, repeatability, and cost efficiency.\n\nIn the literature, both extraoral and intraoral applications of US have been reported. Extraoral applications mainly focus on the characterization of oral and maxillofacial swellings of various origin, while intraoral applications mostly involve the study of malignant lesions in terms of tumor thickness and depth of invasion. The aim of the present protocol is to evaluate the role of intraoral ultra-high frequency ultrasonography in the study of oral mucosal lesions.",[66],"Oral Squamous Cell Carcinoma",[68,69,70],"oral neoplasm","ultrasonography","depth of invasion","2026-02-24",{"date":73,"type":74},"2026-02-25","ACTUAL",{"date":76,"type":74},"2018-06-07",{"date":78,"type":60},"2030-12-31",{"name":5,"class":6},1]