[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635739":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":30,"locations":40,"responsibleParty":67,"collaborators":25,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":25,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":25,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":25,"overallStatus":61,"whyStopped":25,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Fundacion Dexeus","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard Vitrification Protocol","ACTIVE_COMPARATOR","The standard vitrification protocol corresponds to the routine clinical practice of the laboratory and consists of the following steps:\n\n1. Equilibration step: Blastocysts are equilibrated in Equilibration Solution (ES) for 10-12 minutes at room temperature.\n2. Vitrification solution exposure: Blastocysts are then transferred to Vitrification Solution (VS) for a maximum exposure time of 90 seconds.\n3. Loading: The blastocyst is loaded onto a Cryotop device (Kitazato).\n4. Vitrification: The Cryotop is plunged directly into liquid nitrogen within 1 second of loading to ensure ultra-rapid cooling.\n5. Capping: The Cryotop is immediately capped under liquid nitrogen conditions.",[13],"Other: Standard Vitrification",{"label":15,"type":16,"description":17,"interventionNames":18},"Ultra-Rapid Vitrification Protocol","EXPERIMENTAL","The ultra-rapid vitrification protocol is identical to the standard protocol in terms of media, devices, and laboratory conditions, with the following modifications:\n\nPreparation step - Blastocyst shrinkage: Prior to equilibration, artificial collapse of the blastocyst is performed using a single laser pulse to induce blastocoel shrinkage.\n\nThe subsequent steps are:\n\n1\\. Equilibration step: Blastocysts are equilibrated in Equilibration Solution (ES) for 2-4 minutes.\n\nVitrification solution exposure: Transfer to Vitrification Solution (VS) for a maximum of 90 seconds.\n\n3\\. Loading: Loading of the blastocyst onto a Cryotop device. 4. Vitrification: Immediate plunging of the Cryotop into liquid nitrogen within 1 second.\n\n5\\. Capping: Immediate capping under liquid nitrogen.",[19],"Other: Ultra-Rapid Vitrification",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Standard Vitrification","1. Equilibration step: Blastocysts are equilibrated in Equilibration Solution (ES) for 10-12 minutes at room temperature.\n2. Vitrification solution exposure: Blastocysts are then transferred to Vitrification Solution (VS) for a maximum exposure time of 90 seconds.\n3. Loading: The blastocyst is loaded onto a Cryotop device (Kitazato).\n4. Vitrification: The Cryotop is plunged directly into liquid nitrogen within 1 second of loading to ensure ultra-rapid cooling.\n5. Capping: The Cryotop is immediately capped under liquid nitrogen conditions.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Ultra-Rapid Vitrification","The ultra-rapid vitrification protocol is identical to the standard protocol in terms of media, devices, and laboratory conditions, with the following modifications:\n\nPreparation step - Blastocyst shrinkage: Prior to equilibration, artificial collapse of the blastocyst is performed using a single laser pulse to induce blastocoel shrinkage.\n\nThe subsequent steps are:\n\n1. Equilibration step: Blastocysts are equilibrated in Equilibration Solution (ES) for 2-4 minutes.\n2. Vitrification solution exposure: Transfer to Vitrification Solution (VS) for a maximum of 90 seconds.\n3. Loading: Loading of the blastocyst onto a Cryotop device.\n4. Vitrification: Immediate plunging of the Cryotop into liquid nitrogen within 1 second.\n5. Capping: Immediate capping under liquid nitrogen.",[15],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Monica Parriego, PhD","CONTACT","0034932274700","monpar@dexeus.com",{"name":37,"role":33,"phone":34,"phoneExt":38,"email":39},"Ignacio Rodríguez, MSc","22029","nacrod@dexeus.com",[41,60],{"facility":42,"status":43,"city":44,"state":25,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Hospital Universitario Quiron Dexeus","NOT_YET_RECRUITING","Barcelona","08028","Spain","ES",{"type":49,"coordinates":50},"Point",[51,52],2.15899,41.38879,{"lat":52,"lon":51},[55,56,58],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},{"name":57,"role":33,"phone":34,"phoneExt":25,"email":39},"Ignacio Rodriguez, MSc",{"name":32,"role":59,"phone":25,"phoneExt":25,"email":25},"PRINCIPAL_INVESTIGATOR",{"facility":42,"status":61,"city":44,"state":25,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":62,"geoPoint":64,"contacts":65},"RECRUITING",{"type":49,"coordinates":63},[51,52],{"lat":52,"lon":51},[66],{"name":37,"role":33,"phone":34,"phoneExt":25,"email":39},{"type":68,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100635739","ultra-rapid-blastocyst-vitrification-pilot-randomized-study-100635739",false,"NCT07556601","Ultra-rapid Blastocyst Vitrification: Pilot Randomized Study","Clinical Validation of Ultra-rapid Blastocyst Vitrification: a Randomized Pilot Study in Oocyte Donation Cycles","Inclusion Criteria:\n\n* Recipients of donor oocytes\n* Blastocysts suitable for cryopreservation\n\nExclusion Criteria:\n\n* Cycles involving PGT\n* Cycles not reaching blastocyst stage.","FEMALE","18 Years","50 Years",{"count":80,"type":81},80,"ESTIMATED","INTERVENTIONAL",[84],"NA","Blastocyst vitrification is standard in assisted reproduction, but clinical data on ultra-rapid vitrification are limited. This pilot study evaluates the safety, feasibility, and preliminary clinical performance of an ultra-rapid blastocyst vitrification protocol compared with the standard approach.",[87],"Infertility","2026-06-29",{"date":90,"type":91},"2026-06-30","ACTUAL",{"date":93,"type":91},"2026-06-01",{"date":95,"type":81},"2028-03",{"name":5,"class":6},2]