[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100571749":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":8,"locations":7,"responsibleParty":14,"collaborators":7,"id":18,"slug":19,"hasResults":20,"nctId":21,"briefTitle":22,"officialTitle":23,"acronym":7,"eligibilityCriteria":24,"healthyVolunteers":20,"sex":25,"minAge":26,"maxAge":7,"enrollmentInfo":27,"targetDuration":7,"studyType":30,"phases":7,"briefSummary":31,"conditions":32,"keywords":34,"overallStatus":38,"whyStopped":7,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":7},{"fullName":5,"class":6},"Tanta University","OTHER",null,[9],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},"Amer Soliman","CONTACT","+201094963127","amer.soliman0@gmail.com",{"type":15,"investigatorFullName":16,"investigatorTitle":17,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Amer Bahir Soliman","Principal investigator","100571749","ultrasound-assessment-of-the-thickening-fraction-of-the-respiratory-muscles-for-predicting-weaning-outcomes-100571749",false,"NCT06724302","Ultrasound Assessment of the Thickening Fraction of the Respiratory Muscles for Predicting Weaning Outcomes","The Accuracy of Ultrasound Assessment of the Thickening Fraction of the Diaphragm, Parasternal Intercostal, and Abdominal Expiratory Muscles for Predicting Weaning Outcomes in Mechanically Ventilated Patients","Inclusion Criteria:\n\n* Patients will be enrolled if they are ≥18 years old, on invasive mechanical ventilation (MV) for more than 48 h and are eligible for first spontaneous breathing trial (SBT) after fulfilling all the following criteria:\n\n  1. Resolution or improvement of the disease leading to MV.\n  2. Adequate oxygenation, indicated by arterial oxygen partial pressure to inspired oxygen fraction (PaO2\u002FFiO2) ≥ 200 mmHg, both with positive end-expiratory pressure (PEEP) ≤ 5 cmH2O and rapid shallow breathing index\\\u003C 105.\n  3. Adequate pulmonary function, indicated by a RR\\\u003C30 breaths\u002Fmin with VT ≥5 mL\u002Fkg ideal body weight (IBW) and no significant respiratory acidosis with normal serum electrolytes.\n  4. Stable hemodynamics status, without or with minimal vasopressors\n  5. Conscious and cooperative patient\n  6. Absence of excessive tracheobronchial secretion (\\\u003C3 times suction in the past 8 hours).\n  7. Effective cough reflex .Exclusion Criteria:\n\n  \u003C!-- -->\n\n  1. Pregnancy.\n  2. Presence of tracheostomy, pleural effusion, pneumothorax, pneumomediastinum, or hemothorax.\n  3. Presence of rib fractures.\n  4. Pre-existing cervical spinal injury, history or final diagnosis of neuromuscular disorders, and diaphragmatic paralysis or disorders\n  5. Use of neuromuscular blocking agents within 48 hours.\n  6. A distorted abdominal wall anatomy, or damage to the abdominal wall.\n  7. Patients with localized fluid collections in the abdomen, hernias, abdominal wall hematomas, inguinal masses, femoral hernias, abdominal surgeries.\n  8. BMI≥ 40\n  9. Patients with previously failed SBT","ALL","18 Years",{"count":28,"type":29},80,"ESTIMATED","OBSERVATIONAL","The accuracy of ultrasound assessment of the thickening fraction of the diaphragm, parasternal intercostal, and abdominal expiratory muscles for predicting weaning outcomes in mechanically ventilated patients. A prospective observational study",[33],"Weaning From Mechanical Ventilation",[35,36,37],"diaghragm","Parasternal intercostal","Abdominal expiratory","NOT_YET_RECRUITING","2024-12-06",{"date":41,"type":42},"2024-12-09","ACTUAL",{"date":44,"type":29},"2025-01",{"date":46,"type":29},"2026-12",{"name":5,"class":6}]