[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600591":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":33,"locations":33,"responsibleParty":34,"collaborators":33,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":40,"sex":46,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":33,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":33,"overallStatus":62,"whyStopped":33,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":33},{"fullName":5,"class":6},"Sinai University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental: Propolis Phonophoresis","EXPERIMENTAL","Participants will receive topical application of 10% propolis gel on the diabetic foot ulcer followed by therapeutic ultrasound (phonophoresis) using 1 MHz frequency, 0.5-1.5 W\u002Fcm² intensity, pulsed mode (20%), for 5 minutes per session, 3 sessions\u002Fweek for 4 weeks\n\n.Interventions:\n\n* Drug: Propolis gel (10%)\n* Device: Therapeutic ultrasound (phonophoresis)",[13,14],"Device: Sham ultrasound (placebo)","Drug: Propolis gel (10%)",{"label":16,"type":17,"description":18,"interventionNames":19},"Standard Wound Care + Sham Ultrasound","PLACEBO_COMPARATOR","Participants will receive conventional wound care including debridement, cleaning, and dressing. A sham ultrasound device that emits no therapeutic waves will be applied to simulate the intervention procedure.\n\nInterventions:\n\n* Other: Standard wound care procedures\n* Device: Sham ultrasound (placebo)",[13],[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Sham ultrasound (placebo)","Participants will receive conventional wound care including debridement, cleaning, and dressing. A sham ultrasound device that emits no therapeutic waves will be applied to simulate the intervention procedure.",[9,16],[27],"Standard wound care procedures (placebo)",{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"DRUG","Propolis gel (10%)","Participants will receive topical application of 10% propolis gel on the diabetic foot ulcer followed by therapeutic ultrasound (phonophoresis) using 1 MHz frequency, 0.5-1.5 W\u002Fcm² intensity, pulsed mode (20%), for 5 minutes per session, 3 sessions\u002Fweek for 4 weeks.",[9],null,{"type":35,"investigatorFullName":36,"investigatorTitle":37,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"PRINCIPAL_INVESTIGATOR","Amany Gomaa Atiaa","lecturer","100600591","ultrasound-enhanced-propolis-therapy-for-healing-diabetic-foot-wounds-100600591",false,"NCT07099482","\"Ultrasound-Enhanced Propolis Therapy for Healing Diabetic Foot Wounds\"","Effectiveness of Propolis Phonophoresis on Wound Healing in Diabetic Ulcer: a Randomized Controlled Trial","PEARL","Inclusion Criteria:\n\nAdults aged 18 to 75 years\n\nDiagnosed with type 1 or type 2 diabetes mellitus\n\nPresence of a diabetic foot ulcer classified as Grade 1 or 2 (Wagner classification)\n\nUlcer size between 1 cm² and 5 cm²\n\nAble and willing to provide informed consent\n\nExclusion Criteria:\n\nSevere infection or presence of osteomyelitis at the ulcer site\n\nUse of systemic immunosuppressants or corticosteroids\n\nKnown allergy or hypersensitivity to propolis\n\nPregnant or breastfeeding women\n\nParticipation in another clinical trial within the past 30 days","ALL","18 Years","75 Years",{"count":50,"type":51},80,"ESTIMATED","INTERVENTIONAL",[54],"NA","This study aims to evaluate whether using ultrasound (phonophoresis) can help deliver propolis-a natural compound made by bees-more effectively into the skin to speed up wound healing in people with diabetic foot ulcers. Diabetic foot ulcers are a common and serious complication of diabetes and often take a long time to heal. Propolis has natural anti-inflammatory and antimicrobial properties that may promote healing, but it does not easily penetrate the skin. By using ultrasound to enhance absorption, this study tests whether combining propolis with phonophoresis is more effective than standard wound care alone. Participants will be randomly assigned to receive either the propolis ultrasound therapy or standard care. The study will measure wound size, healing time, pain, infection rates, and quality of life.",[57,58,59,60,61],"Diabetic Foot Ulcer t","Type 1 Diabetes Mellitus","Type 2 Diabetes Mellitus","Wound Management","Chronic Wound Healing","NOT_YET_RECRUITING","2026-05-05",{"date":65,"type":66},"2026-05-06","ACTUAL",{"date":68,"type":51},"2026-05-30",{"date":70,"type":51},"2026-09-25",{"name":5,"class":6}]