[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624125":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":20,"locations":26,"responsibleParty":39,"collaborators":10,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":10,"eligibilityCriteria":47,"healthyVolunteers":43,"sex":48,"minAge":49,"maxAge":10,"enrollmentInfo":50,"targetDuration":10,"studyType":53,"phases":10,"briefSummary":54,"conditions":55,"keywords":60,"overallStatus":66,"whyStopped":10,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"Bursa Sevket Yilmaz Training and Research Hospital","OTHER_GOV",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Pneumonia ICU Patients on Invasive Mechanical Ventilation",null,"This cohort includes adult intensive care unit patients admitted with pneumonia who are receiving invasive mechanical ventilation via endotracheal intubation. All participants will undergo serial bedside ultrasonographic assessments of the diaphragm, parasternal intercostal muscles, and anterior scalene muscles during the weaning process. No therapeutic intervention is assigned as part of the study, and all clinical management decisions, including ventilator settings and weaning strategies, are determined by the treating ICU team according to standard care.",[13],"Other: No intervention (observational study)",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"OTHER","No intervention (observational study)","This is an observational study with no assigned therapeutic intervention. Serial ultrasonographic assessments of respiratory muscles are performed for observational and data collection purposes only, and all clinical care and weaning decisions are made by the treating intensive care unit team according to standard practice.",[9],[21],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Gürcan Güler","CONTACT","+90 541 975 0407","gurcanguler.45@gmail.com",[27],{"facility":28,"status":10,"city":29,"state":10,"zip":10,"country":30,"countryCode":10,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"Principal Investigator","Bursa","Turkey (Türkiye)",{"type":32,"coordinates":33},"Point",[34,35],29.06013,40.19559,{"lat":35,"lon":34},[38],{"name":28,"role":23,"phone":24,"phoneExt":10,"email":25},{"type":40,"investigatorFullName":22,"investigatorTitle":28,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","100624125","ultrasound-evaluation-of-respiratory-muscles-during-mechanical-ventilation-weaning-in-icu-patients-100624125",false,"NCT07405567","Ultrasound Evaluation of Respiratory Muscles During Mechanical Ventilation Weaning in ICU Patients","Ultrasonographic Evaluation of Diaphragm and Accessory Respiratory Muscles During Weaning in ICU Patients With Pneumonia","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Admission to the intensive care unit with a diagnosis of pneumonia\n* Receiving invasive mechanical ventilation via endotracheal intubation\n* Expected to undergo a weaning process from mechanical ventilation\n* Written informed consent obtained from the patient or legally authorized representative\n\nExclusion Criteria:\n\n* Known neuromuscular disease affecting respiratory muscles\n* High cervical spinal cord injury\n* History of major neck, thoracic, or diaphragmatic surgery\n* Acute thoracic trauma or pneumothorax\n* Central nervous system pathology affecting respiratory drive\n* Continuous neuromuscular blocking agent use\n* Pregnancy","ALL","18 Years",{"count":51,"type":52},150,"ESTIMATED","OBSERVATIONAL","Patients with pneumonia who require invasive mechanical ventilation in the intensive care unit (ICU) often experience difficulties during the process of being separated from the breathing machine (weaning). Failure of weaning is associated with longer ventilation duration, prolonged ICU stay, and increased risk of complications and death. Therefore, simple and reliable bedside tools are needed to better understand respiratory muscle function and to help predict weaning outcomes.\n\nThis prospective, observational, single-center study aims to evaluate respiratory muscle function using bedside ultrasound in adult ICU patients with pneumonia receiving invasive mechanical ventilation. The diaphragm, parasternal intercostal muscles, and anterior scalene muscles will be assessed using ultrasound during the weaning process. Measurements will be performed serially, starting from the first day when patients demonstrate meaningful spontaneous breathing effort and continuing until successful extubation, tracheostomy, or ICU mortality.\n\nUltrasound measurements of muscle thickness and thickening fraction will be analyzed in relation to weaning outcomes. In addition, ventilator parameters and commonly used weaning indices will be recorded at the time of each ultrasound assessment. The findings of this study are expected to improve understanding of respiratory muscle involvement during weaning and may contribute to earlier identification of patients at risk of weaning failure.",[56,57,58,59],"Pneumonia","Invasive Mechanical Ventilation","Weaning From Mechanical Ventilation in Care Unit","Respiratory Muscle Dysfunction",[61,62,63,64,65],"Mechanical Ventilation Weaning","Respiratory Muscle Ultrasound","Diaphragm Ultrasound","Parasternal Intercostal Muscle","Anterior Scalene Muscle","NOT_YET_RECRUITING","2026-02-05",{"date":69,"type":70},"2026-02-12","ACTUAL",{"date":72,"type":52},"2026-02-15",{"date":74,"type":52},"2027-02-15",{"name":5,"class":6},1]