[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100571847":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":23,"centralContacts":27,"locations":36,"responsibleParty":54,"collaborators":58,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":10,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":10,"studyType":78,"phases":10,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":39,"whyStopped":10,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Ablation Group",null,"Patients in this group received ablation therapy for low-risk papillary thyroid carcinoma. The ablation method used was microwave ablation (MWA), with ablation performed under ultrasound guidance. Patients were informed of the potential risks and benefits of ablation, and follow-ups were conducted at regular intervals using thyroid ultrasound and contrast-enhanced ultrasound to evaluate treatment efficacy and disease progression.",[13],"Procedure: Ablation",{"label":15,"type":10,"description":16,"interventionNames":10},"Surgery Group","Patients in this group underwent surgical treatment for low-risk papillary thyroid carcinoma. The surgery performed was partial or total thyroidectomy, based on the patient's condition and preferences. Patients were informed of the risks, including potential complications such as hypothyroidism, recurrent laryngeal nerve injury, and hypoparathyroidism. Follow-ups were conducted using thyroid ultrasound and clinical assessments to monitor for recurrence and evaluate postoperative recovery.",[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"PROCEDURE","Ablation","Thyroid ablation performed under ultrasound guidance to treat low-risk papillary thyroid carcinoma.",[9],[24],{"name":25,"affiliation":5,"role":26},"Miaoyun Long, MD","STUDY_DIRECTOR",[28,32],{"name":25,"role":29,"phone":30,"phoneExt":10,"email":31},"CONTACT","86-34070602","longmy@mail.sysu.edu.cn",{"name":33,"role":29,"phone":34,"phoneExt":10,"email":35},"Yuxin Shen, MBBS","86-15083138712","shenyx53@mail2.sysu.edu.cn",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Sun Yat-sen Memorial Hospital, Sun Yat-sen University","RECRUITING","Guangzhou","Guangdong","510030","China","CN",{"type":46,"coordinates":47},"Point",[48,49],113.25,23.11667,{"lat":49,"lon":48},[52,53],{"name":25,"role":29,"phone":30,"phoneExt":10,"email":31},{"name":33,"role":29,"phone":34,"phoneExt":10,"email":35},{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Longmiaoyun","Chief Physician",[59,62],{"name":60,"class":61},"National Natural Science Foundation of China","OTHER_GOV",{"name":63,"class":64},"Guangzhou Science and Technology Innovation Commission,China","UNKNOWN","100571847","ultrasound-guided-microwave-ablation-vs-surgery-for-low-risk-papilarythyroid-carcinoma-100571847",false,"NCT06725576","Ultrasound-Guided Microwave Ablation Vs. Surgery for Low-Risk PapilaryThyroid Carcinoma","Ultrasound and Gene-Guided Microwave Ablation Versus Surgery for Low-Risk Papillary Thyroid Carcinoma: a Prospective Observational Cohort Study.","The inclusion criteria of this study were as followed:\n\n1. PTC confirmed by fine-needle aspiration (FNA);\n2. Confirmed low-risk mutation types by next-generation sequencing (NGS) before surgery;\n3. No severe functional diseases, such as heart failure, severe respiratory diseases, or renal failure;\n4. Availability of complete follow-up data.\n\nThe exclusion criteria were as followed:\n\n1. No local or distant metastasis assessed by imaging evaluations, including ultrasound or computed tomography (CT);\n2. Lacking of preoperative genetic testing or inability to assess genetic test results;\n3. Inability to complete follow-up or lost to follow-up during the study.\n\nLow-risk PTC is defined as:\n\n1. Maximum tumor diameter ≤1 cm;\n2. Solitary lesion;\n3. No local or distant metastasis;\n4. No tumor invasion into extrathyroidal tissues;\n5. No vascular invasion;\n6. Non-invasive pathological subtype for the primary lesion (invasive subtypes include tall cell, columnar cell, diffuse sclerosing, solid\u002Ftrabecular, and oncocytic vari ants);\n7. No history of head and neck radiotherapy during adolescence;\n8. No family history of thyroid cancer;\n9. Genetic testing showing BRAF V600E mutation (without concurrent TERT mutation), RAS family gene mutations, (HRAS, NRAS, KRAS), or other low-risk mutations, such as isolated RET\u002FPTC) rearrangements.\n\nIntermediate-high risk PTC is defined as:\n\n1. Maximum tumor diameter \\>1 cm;\n2. Multifocal thyroid cancer;\n3. Local or distant metastasis;\n4. Primary lesion with extrathyroidal extension;\n5. Vascular invasion;\n6. Primary lesion with an invasive pathological subtype;\n7. History of head and neck radiotherapy during adolescence;\n8. Family history of thyroid cancer;\n9. Genetic testing revealing high-risk mutation combinations, such as BRAF V600E or RAS mutations with concurrent TERT or TP53 mutations, or RAS mutations combined with EIF1AX mutations.","ALL","18 Years","70 Years",{"count":76,"type":77},201,"ESTIMATED","OBSERVATIONAL","This study aims to investigate the efficacy and prognosis of ultrasound-guided and gene-based microwave ablation (MWA) versus surgical treatment in patients with low-risk papillary thyroid carcinoma (PTC). By analyzing genetic testing results, the study explores the impact of genetic mutations on treatment selection for low-risk patients, providing more precise molecular biological evidence for treatment choices and prognosis evaluation of thyroid cancer. This prospective study collects clinical data from patients diagnosed with PTC at Sun Yat-sen Memorial Hospital of Sun Yat-sen University between January 2022 and November 2024, who underwent genetic testing prior to treatment, and assesses efficacy and complications through long-term follow-up.",[81],"Thyroid Cancer, Papillary",[83,84,85,86],"Papillary Thyroid Carcinoma","Ablation Therapy","Personalized treatment","Thyroid cancer gene mutations","2024-12-25",{"date":89,"type":90},"2024-12-31","ACTUAL",{"date":92,"type":90},"2022-01-01",{"date":94,"type":77},"2025-03-04",{"name":5,"class":6},1]