[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584093":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":30,"locations":36,"responsibleParty":62,"collaborators":29,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":29,"eligibilityCriteria":70,"healthyVolunteers":67,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":29,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":29,"overallStatus":39,"whyStopped":29,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"National Cancer Institute, Egypt","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Erector spinae plane block (ESPB)","EXPERIMENTAL","Erector spinae plane block (ESPB) using multilevel injections of bupivacaine 0.25%.\n\nWe injected 15ml at the level of T2 and 15ml at the level of T5.",[13],"Drug: Erector spinae plane block (ESPB)",{"label":15,"type":10,"description":16,"interventionNames":17},"Thoracic epidural block","Thoracic epidural block at level of T5 -T6 using 10 ml of bupivacaine 0.25% as a bolus followed by 5 ml bupivacaine 0.25% every 1-2 hours depending on the duration of surgery and the response of the patient.",[18],"Drug: Thoracic epidural block",[20,26],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","Erector spinae plane block (ESPB) using multilevel injections of bupivacaine 0.25%.\n\nWe will inject 15ml at the level of T2 and 15ml at the level of T5.",[9],[25],"Bupivacaine 0.25%",{"type":21,"name":15,"description":16,"armGroupLabels":27,"otherNames":28},[15],[25],null,[31],{"name":32,"role":33,"phone":34,"phoneExt":29,"email":35},"Ahmed El Abdelaal, Master","CONTACT","00201097900275","drahmedsayeh9915@gmail.com",[37],{"facility":38,"status":39,"city":40,"state":29,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"National Cancer Institute","RECRUITING","Cairo","11796","Egypt","EG",{"type":45,"coordinates":46},"Point",[47,48],31.24967,30.06263,{"lat":48,"lon":47},[51,52,55,57,60],{"name":32,"role":33,"phone":34,"phoneExt":29,"email":35},{"name":53,"role":54,"phone":29,"phoneExt":29,"email":29},"Ghada G Elsayed, MD","SUB_INVESTIGATOR",{"name":56,"role":54,"phone":29,"phoneExt":29,"email":29},"Mohamed A Abdelwadoud, MD",{"name":58,"role":59,"phone":29,"phoneExt":29,"email":29},"Mai M Elrawas, MD","PRINCIPAL_INVESTIGATOR",{"name":61,"role":54,"phone":29,"phoneExt":29,"email":29},"Doaa A Mohamed, MD",{"type":59,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"Dr Ahmed elsayeh","Assistant Lecturer of Anesthesiology, Surgical Intensive Care Unit and Pain Medicine, National Cancer Institute ,Cairo University, Egypt","100584093","ultrasound-guided-multilevel-erectorspinae-plane-block-versus-thoracic-epidural-analgesia-for-prevention-of-post-mastectomy-pain-syndrome-for-breast-cancer-patients-100584093",false,"NCT06884852","Ultrasound-guided Multilevel Erectorspinae Plane Block Versus Thoracic Epidural Analgesia for Prevention of Post Mastectomy Pain Syndrome for Breast Cancer Patients","Inclusion Criteria:\n\n* Female patients age ≥ 18 years and ≤ 65 Years.\n* Type of surgery; Modified Radical Mastectomy (MRM)\n* Physical status ASA II, III.\n* Body mass index (BMI): \\> 20 kg\u002Fm2 and \\\u003C 35 kg\u002Fm2.\n\nExclusion Criteria:\n\n* Patient refusal.\n* Allergy or a contraindication to the drug used in the study, e.g. local anesthetics, opioids.\n* History of psychological disorders.\n* History of chronic pain.\n* Contraindication to regional anesthesia e.g. sepsis, peripheral neuropathies and coagulopathy.\n* Advanced chronic renal disease, which is defined as a chronic kidney disease (CKD) in which there is a severe reduction in glomerular filtration rate (GFR \\\u003C 30 ml\u002Fmin) and includes stages 4 and 5 of the CKD classification.\n* Decompensated cirrhosis, which is defined as an acute deterioration in liver function in a patient with cirrhosis and is characterized by jaundice, ascites, hepatic encephalopathy, hepatorenal syndrome, or variceal hemorrhage.\n* Severe heart disease which is defined as NYHA class iii (moderate symptoms with less than normal activity, marked limitation of function status) or NYHA class IV (severe symptoms with features of heart failure with minimal activity or at rest and severe limitation of functional status)\n* Severe lung disease which includes oxygen saturation of blood less than 92%, RR more than 20, FEV1\u002FFVC ratio less than 60%.\n* Pregnancy.","FEMALE","18 Years","65 Years",{"count":75,"type":76},44,"ESTIMATED","INTERVENTIONAL",[79],"NA","The aim of this study is to compare the analgesic efficacy of multilevel erector spinae plane block (ESPB) vs thoracic epidural in modified radical mastectomy (MRM) regarding duration of analgesia, postoperative opioid consumption, effect on intraoperative fentanyl consumption, postoperative numerical pain rating scale and quality of life for the next 6 months.",[82,83,84,85,86,87],"Ultrasound","Multilevel Erector Spinae Plane Block","Thoracic Epidural Analgesia","Post Mastectomy","Pain Syndrome","Breast Cancer Patients","2025-05-18",{"date":90,"type":91},"2025-05-21","ACTUAL",{"date":93,"type":91},"2025-03-20",{"date":95,"type":76},"2026-03-01",{"name":5,"class":6},1]