[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640546":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":34,"locations":40,"responsibleParty":71,"collaborators":26,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":77,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":26,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":98,"overallStatus":105,"whyStopped":26,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":113,"locationsCount":114},{"fullName":5,"class":6},"Ukrainian Society of Regional Anesthesia and Pain Therapy","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"PRP Injection Around Neuroma","EXPERIMENTAL","Ultrasound-guided perineuroma platelet-rich plasma (PRP) injection performed for treatment of chronic neuroma pain after combat-related amputation. PRP will be prepared using autologous blood and injected under sterile conditions around the ultrasound-confirmed painful neuroma.",[13],"Biological: Platelet-Rich Plasma (PRP) Injections",{"label":15,"type":16,"description":17,"interventionNames":18},"Local Anesthetic Injection","ACTIVE_COMPARATOR","Ultrasound-guided perineuroma local anesthetic injection performed for treatment of chronic neuroma pain after combat-related amputation under sterile conditions around the ultrasound-confirmed painful neuroma.",[19],"Drug: Local Anesthetic Injection",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BIOLOGICAL","Platelet-Rich Plasma (PRP) Injections","Ultrasound-guided perineuroma platelet-rich plasma injection performed around the ultrasound-confirmed painful neuroma for treatment of chronic neuroma pain after combat-related amputation.",[9],null,{"type":28,"name":15,"description":29,"armGroupLabels":30,"otherNames":31},"DRUG","Ultrasound-guided perineuroma local anesthetic injection performed around the ultrasound-confirmed painful neuroma for treatment of chronic neuroma pain after combat-related amputation.",[15],[32,33],"Lidocaine","Bupivacaine",[35],{"name":36,"role":37,"phone":38,"phoneExt":26,"email":39},"Dmytro Dmytriiev, PhD.Professor","CONTACT","+380674309449","mddmytriiev@gmail.com",[41,58],{"facility":42,"status":26,"city":43,"state":26,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Feofaniya Clinical Hospital","Kyiv","03143","Ukraine","UA",{"type":48,"coordinates":49},"Point",[50,51],30.5238,50.45466,{"lat":51,"lon":50},[54],{"name":55,"role":37,"phone":56,"phoneExt":26,"email":57},"Andrii Khomenko, MD","+380937635858","farmen@ukr.net",{"facility":59,"status":26,"city":60,"state":26,"zip":61,"country":45,"countryCode":46,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"Vinnitsya university hospital","Vinnytsia","21000",{"type":48,"coordinates":63},[64,65],28.46871,49.2322,{"lat":65,"lon":64},[68],{"name":69,"role":37,"phone":70,"phoneExt":26,"email":39},"Dmytro Dmytriiev, Phd","0674309449",{"type":72,"investigatorFullName":73,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Dmytro Dmytriiev","MD, PhD, Professor","100640546","ultrasound-guided-platelet-rich-plasma-versus-local-anesthetic-injection-for-chronic-neuroma-pain-after-combat-related-amputation-100640546",false,"NCT07624890","Ultrasound-Guided Platelet-Rich Plasma Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation","Ultrasound-Guided Platelet-Rich Plasma Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation: A Prospective Multicenter Controlled Study","PRP-NEUROMA","Inclusion Criteria:\n\n* Age ≥18 years\n* Combat-related limb amputation\n* Chronic neuroma pain lasting ≥3 months\n* Ultrasound-confirmed painful neuroma\n* Average neuroma pain intensity ≥4\u002F10 on the Numeric Rating Scale\n* Persistent pain interfering with rehabilitation, prosthesis use, or daily activities\n* Ability to undergo ultrasound-guided injection\n* Stable analgesic regimen for at least 14 days before enrollment\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Active infection at or near the injection site\n* Open wound preventing safe injection\n* Previous PRP injection for neuroma pain within 6 months\n* Previous neuroma surgery within 3 months\n* Severe coagulopathy or platelet disorder\n* Anticoagulant therapy contraindicating injection\n* Active malignancy\n* Severe uncontrolled systemic disease\n* Known allergy to local anesthetics\n* Inability to complete follow-up assessments","ALL","18 Years","60 Years",{"count":87,"type":88},100,"ESTIMATED","INTERVENTIONAL",[91],"NA","Patients with combat-related amputations frequently experience chronic neuroma pain that may interfere with rehabilitation, prosthesis use, mobility, sleep, and quality of life. Current treatment approaches often provide only temporary pain relief.\n\nPlatelet-rich plasma (PRP) has emerged as a potential regenerative treatment option because of its possible effects on tissue healing, neuroinflammation, and peripheral nerve irritation. However, its role in the treatment of chronic neuroma pain after amputation remains unclear.\n\nThis prospective multicenter controlled study aims to compare ultrasound-guided PRP injection around the neuroma with ultrasound-guided local anesthetic injection in patients with chronic neuroma pain after combat-related amputation.\n\nParticipants will undergo one of the two injection treatments and will be followed over time to evaluate changes in pain intensity, neuropathic pain symptoms, phantom limb pain, prosthesis tolerance, and functional outcomes.\n\nThe goal of the study is to evaluate the safety, feasibility, and potential clinical effectiveness of PRP injection for chronic neuroma pain following combat-related amputation.",[94,95,96,97],"Neuroma","Phantom Limb Pain After Amputation","Stump Pain","Platelet-rich Plasma (PRP)",[99,100,101,102,103,104],"Chronic Neuroma Pain","Residual Limb Pain","Combat-Related Amputation","Post-Amputation Pain Syndrome","Painful Stump Neuroma","Platelet-rich plasma","NOT_YET_RECRUITING","2026-05-30",{"date":108,"type":109},"2026-06-03","ACTUAL",{"date":111,"type":88},"2026-12-15",{"date":111,"type":88},{"name":5,"class":6},2]