[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634083":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":25,"responsibleParty":40,"collaborators":25,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":25,"eligibilityCriteria":50,"healthyVolunteers":46,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":25,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":67,"whyStopped":25,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":25},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Ultrasound guided platelet rich fibrin injection.","EXPERIMENTAL","Patient receive PRF injection under ultrasound guidance",[13],"Device: ultrasound guided platelet rich fibrin injection",{"label":15,"type":10,"description":16,"interventionNames":17},"Arthroscopic guided platelet-rich fibrin injection.","Patient receive PRF injection under arsothscopic guidance",[18],"Device: Arthroscopic guided platelet rich Fibrin injection",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","ultrasound guided platelet rich fibrin injection","1. A high-frequency linear ultrasound probe will be used to identify the TMJ space.\n2. A sterile syringe containing 1 mL of PRF will be inserted into the superior joint space under real-time ultrasound guidance.\n3. PRF will be injected slowly with continuous confirmation of needle position.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Arthroscopic guided platelet rich Fibrin injection","1. TMJ arthroscopy will be performed under local or general anesthesia following standard aseptic preparation.\n2. The superior joint space will be visualized using a 1.9 mm arthroscope.\n3. A sterile syringe containing 1 mL of PRF will be introduced through a lateral portal under direct arthroscopic visualization.\n4. PRF will be injected slowly into the superior joint space.",[15],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Sami Faiz Kahwaji, DDS","CONTACT","+20 1096094940","sami.kahwaji@dentistry.cu.edu.eg",{"name":37,"role":33,"phone":38,"phoneExt":25,"email":39},"Khalid Atef Elhayes, PhD","+20 1030000360","khaled.atef@dentistry.cu.edu.eg",{"type":41,"investigatorFullName":42,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Sami faiz kahwaji","Principal investigator, postgraduate researcher","100634083","ultrasound-guided-versus-arthroscopic-guided-prf-injection-for-tmj-disc-displacement-100634083",false,"NCT07535073","Ultrasound-guided Versus Arthroscopic Guided PRF Injection for TMJ Disc Displacement.","Ultrasound Guided Versus Arthroscopic Guided PRF Injection in Management of Temporomandibular Joint Disc Displacement With Reduction: A Randomized Controlled Clinical Trials","Inclusion Criteria:\n\n* Patients aged 18-60 years.\n* Clinically and radiographically diagnosed temporomandibular joint disc displacemet with reduction.\n* Presence of TMJ pain exacerbated by mandibular movement.\n* Limited mandibular function and\u002For reduced maximum mouth opening.\n* Symptoms persisting for at least 3 months.\n* Failure of conservative treatment (e.g. occlusal splint, physiotherapy, NSAIDs). -Ability to understand the study protocol and provide informed consent.\n\nExclusion Criteria:\n\n* Previous TMJ surgery or arthroscopic intervention.\n* Intra-articular injection in the TMJ within the last 6 months.\n* Systemic inflammatory or autoimmune joint diseases.\n* Coagulation disorders or current anticoagulant therapy.\n* Active local infection at the injection site.\n* Pregnancy or lactation.\n* Severe degenerative joint disease (advanced osteoarthritis).\n* Known allergy or contraindication to ( PRF) preparation.","ALL","18 Years","60 Years",{"count":55,"type":56},18,"ESTIMATED","INTERVENTIONAL",[59],"NA","To compare the clinical effectiveness of ultrasound-guided versus arthroscopic guided platelet rich fibrin injection in the management of anterior disc displacement with reduction of the temporomandibular joint, in terms of pain reduction, improvement of mandibular function, and patient-reported outcomes.",[62],"TMJ Disc Displacement With Reduction",[64,65,66],"temporomandibular joint","Tmj disc displacement","PRF","NOT_YET_RECRUITING","2026-04-09",{"date":70,"type":71},"2026-04-16","ACTUAL",{"date":73,"type":56},"2026-05-07",{"date":75,"type":56},"2027-06-07",{"name":5,"class":6}]