[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621680":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":24,"locations":30,"responsibleParty":50,"collaborators":54,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":10,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":10,"studyType":74,"phases":10,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":84,"whyStopped":10,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"University of British Columbia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"healthy volunteers",null,"who have no known history of liver disease",[13],"Device: Ultrasound and magentic resonance imaging",{"label":15,"type":10,"description":16,"interventionNames":17},"patients with chronic liver disease","with fibrosis stages F0, F1, F2, F3 or F4.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DEVICE","Ultrasound and magentic resonance imaging","For each healthy volunteer and patient, there will be two sessions of imaging. Magnetic resonance imaging, including proton density fat fraction (PDFF) and elastography (MRE) will be acquired. Multi-paramteric, volumetric ultrasound will also be acquired, including shear wave absolute elastography and attenuation, as well as raw radio-frequecy (echo) data. Two systems, a Philips Epiq and a Sonic Incytes Velacur will be used to acquire ultrasound images, including elasticity and attenuation. In addition, Fibroscan measurements (Liver Stiffness measurement and Controlled Attenuation Parameter) will be acquired.",[9,15],[25],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Septimiu Salcudean, PhD","CONTACT","1(604)822-3243","tims@ece.ubc.ca",[31],{"facility":5,"status":10,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Vancouver","British Columbia","V6T1Z4","Canada","CA",{"type":38,"coordinates":39},"Point",[40,41],-123.11934,49.24966,{"lat":41,"lon":40},[44,46],{"name":26,"role":27,"phone":45,"phoneExt":10,"email":29},"604-822-3243",{"name":47,"role":27,"phone":48,"phoneExt":10,"email":49},"Robert Rohling, PhD","604-822-2045","rohling@ece.ubc.ca",{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Septimiu E. Salcudean","Professor",[55,58],{"name":56,"class":57},"Philips Health Care","INDUSTRY",{"name":59,"class":57},"Sonic Incytes","100621680","ultrasound-liver-imaging-for-classification-of-metabolic-dysfunction-associated-steatotic-liver-disease-100621680",false,"NCT07373769","Ultrasound Liver Imaging for Classification of Metabolic Dysfunction-associated Steatotic Liver Disease","Multi-modal, Multi-parametric Liver Imaging for Ultrasound-based Stratification of Patients With MAFLD","Inclusion Criteria:\n\n* Participants between the ages of 19 and 75.\n* healthy volunteers and have no known history of liver disease\n* patients with chronic liver disease, with fibrosis stages F0, F1, F2, F3 or F4.\n\nExclusion Criteria:\n\nDoes not speak and\u002For read English\n\nCANNOT undergo an MRI exam for one of the following reasons:\n\n* Retained wires from an electronic implant that has been removed (i.e. pacemaker wires not attached to a pacemaker)\n* Cardiac pacemaker or defibrillator\n* Metal in eye or orbit\n* Ferromagnetic aneurysm clip\n* Pregnancy\n* Makeup tattoos that are not designed to fade over time\n* Stainless steel intrauterine device (IUD)\n\nDepending on the individual situation, patients MAY NOT be able to participate the MRI exam if they have\u002Fhad any of the following:\n\n* Artificial heart valve\n* Ear or eye implant\n* Brain aneurysm clip\n* Implanted electronic device (i.e. drug infusion pump, electrical stimulator)\n* Coil, catheter, or filter in any blood vessel\n* Orthopedic hardware (artificial joint, plate, screw, rod)\n* Shrapnel, bullets, or other metal fragments\n* Surgery, medical procedure or tattoos (including tattooed eyeliner) in the last six weeks\n* Other metallic prostheses",true,"ALL","19 Years","75 Years",{"count":72,"type":73},145,"ESTIMATED","OBSERVATIONAL","Tissue elasticity and viscosity correlate with pathology. These tissue properties are typically evaluated subjectively using palpation. The purpose of \"elastography\" is to provide an objective elasticity image that is equivalent to the remote palpation of tissue. The investigators have developed elastography imaging systems based on ultrasound and magnetic resonance imaging and have applied them previously to prostate imaging, breast imaging in patients and liver imaging in healthy volunteers.\n\nA first objective of this study is to compare the investigators' ultrasound shear wave absolute vibro-elastography (S-WAVE) technology with the existing clinical standard, FibroScan, and magnetic resonance elastography to quantify liver stiffness in healthy volunteers and in patients suspected of fatty liver disease.\n\nA second objective of this study is to compare ultrasound-based liver tissue fat measurement with MRI-based measurements.\n\nA third objective of this study is to determine whether ultrasound can be used to assess liver inflammation.",[77],"Metabolic Dysfunction-Associated Steatotic Liver Disease",[79,80,81,82,83],"steatosis","fibrosis","Metabolic dysfunction-associated steatotic liver disease","inflammation","liver","NOT_YET_RECRUITING","2026-01-23",{"date":87,"type":88},"2026-01-28","ACTUAL",{"date":90,"type":73},"2026-01-01",{"date":92,"type":73},"2032-07-01",{"name":5,"class":6},1]