[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641671":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":17,"locations":10,"responsibleParty":25,"collaborators":10,"id":28,"slug":29,"hasResults":30,"nctId":31,"briefTitle":32,"officialTitle":32,"acronym":33,"eligibilityCriteria":34,"healthyVolunteers":35,"sex":36,"minAge":37,"maxAge":38,"enrollmentInfo":39,"targetDuration":10,"studyType":42,"phases":10,"briefSummary":43,"conditions":44,"keywords":48,"overallStatus":58,"whyStopped":10,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":10},{"fullName":5,"class":6},"University of Alcala","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Healthy adults",null,"Healthy\u002Fcommunity-dwelling adults aged 18-89 years participating in an observational study evaluating ultrasound-derived muscle biomarkers and their relationship with isometric quadriceps muscle strength and handgrip.",[13],{"name":14,"affiliation":15,"role":16},"Nicola S. Diciolla, PT, Ph.D.","University of Alcalá","PRINCIPAL_INVESTIGATOR",[18,22],{"name":14,"role":19,"phone":20,"phoneExt":10,"email":21},"CONTACT","+34 918 85 48 28","nicola.diciolla@uah.es",{"name":23,"role":19,"phone":20,"phoneExt":10,"email":24},"Beatriz Sánchez-Sánchez, PT, Ph.D.","beatriz.sanchez@uah.es",{"type":16,"investigatorFullName":26,"investigatorTitle":27,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Nicola S. Diciolla","Principal Investigator, Scientific Coordinator","100641671","ultrasound-muscle-biomarkers-as-predictors-of-isometric-quadriceps-muscle-strength-and-handgrip-in-healthy-adults-an-observational-study-100641671",false,"NCT07647393","Ultrasound Muscle Biomarkers as Predictors of Isometric Quadriceps Muscle Strength and Handgrip in Healthy Adults: an Observational Study","MUSCLE-US","Inclusion Criteria:\n\n* Healthy adults aged 18-89 years.\n* Resident in Spain for at least 5 years.\n* Living independently in the community and able to complete all study assessments.\n* Able to understand and follow verbal instructions in Spanish.\n* Able and willing to provide written informed consent prior to study participation.\n\nExclusion Criteria:\n\n* Neurological, musculoskeletal, or systemic disorders affecting muscle strength or mobility.\n* Recent surgery or acute injury affecting the upper or lower limbs.\n* Recent use of medications affecting the musculoskeletal system (e.g., systemic corticosteroids for \\>1 week during the previous 6 months or muscle relaxants during the previous week).\n* Cognitive or psychiatric conditions limiting participation.\n* Pregnancy.\n* Recent postpartum period (≤3 months after delivery).\n* Presence of clinically relevant pain, fatigue, physical deconditioning, or functional limitations that may interfere with study procedures or measurement validity.\n* Acute illness at the time of assessment.\n* Uncontrolled hypertension (≥140\u002F90 mmHg).\n* Resting peripheral oxygen saturation ≤90%.\n* Moderate-to-severe pain (Numeric Rating Scale ≥4\u002F10).\n* Any medical condition considered by the investigator to contraindicate study participation.",true,"ALL","18 Years","89 Years",{"count":40,"type":41},300,"ESTIMATED","OBSERVATIONAL","This observational study aims to determine whether ultrasound-derived muscle biomarkers can predict isometric quadriceps muscle strength and handgrip in healthy adults aged 18-89 years.\n\nThe main questions it aims to answer are:\n\n* Which ultrasound muscle characteristics are associated with isometric quadriceps muscle strength and handgrip?\n* Can ultrasound-derived biomarkers be used to develop predictive models of muscle strength in healthy adults?\n\nParticipants will undergo:\n\n* Ultrasound assessment of the quadriceps and forearm flexor muscles;\n* Measurement of isometric quadriceps muscle strength and handgrip using standardized dynamometry protocols;\n* Assessment of functional capacity, mobility and balance;\n* Completion of questionnaires related to health status, physical activity, nutrition, fatigue and health-related quality of life.\n\nThe study will also assess the reliability of ultrasound measurements and explore the relationship between ultrasound variables, muscle strength, physical function and health-related factors.",[45,46,47],"Healthy Adult","Muscle Strength","Skeletal Muscle Ultrasound",[49,50,51,52,53,54,55,56,57],"Muscle ultrasound","Skeletal muscle ultrasonography","Muscle biomarkers","Isometric quadriceps muscle strength","Handgrip","Muscle thickness","Echo intensity","Muscle quality","Predictive models","NOT_YET_RECRUITING","2026-06-12",{"date":61,"type":62},"2026-06-16","ACTUAL",{"date":64,"type":41},"2026-06",{"date":66,"type":41},"2029-06",{"name":5,"class":6}]