[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589294":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":24,"locations":29,"responsibleParty":55,"collaborators":57,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":24,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":24,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":24,"overallStatus":32,"whyStopped":24,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Study Group","EXPERIMENTAL","Symptomatic patients with claudication, at risk for peripheral arterial disease (PAD)",[13],"Diagnostic Test: Ultrasound Imaging",{"label":15,"type":10,"description":16,"interventionNames":17},"Healthy Volunteers","Healthy volunteers with normal ankle-brachial index (ABI)",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DIAGNOSTIC_TEST","Ultrasound Imaging","Non-invasive ultrasound will be performed using Angio Flow Reactivity Analysis (AFRA)\n\nThe ultrasound probe will be attached to the subject's calf muscle and a pressure cuff will be secured around thigh. Ultrasound data will be collected for 1 minute.\n\nThe cuff will then be induced to a tolerable pressure of no more than 160 mm Hg, and ultrasound data will be collected for 3 minutes while cuff is inflated.\n\nThe cuff pressure will be released, and ultrasound data will be collected for 2 minutes after the release.\n\nSubject will be asked to perform 1 minute plantar flexion exercise, and ultrasound data will be collected for two minutes after the completion of exercise",[15,9],null,[26],{"name":27,"affiliation":5,"role":28},"Azra Alizad","PRINCIPAL_INVESTIGATOR",[30],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Mayo Clinic in Rochester","RECRUITING","Rochester","Minnesota","55905","United States","US",{"type":39,"coordinates":40},"Point",[41,42],-92.4699,44.02163,{"lat":42,"lon":41},[45,50,54],{"name":46,"role":47,"phone":48,"phoneExt":24,"email":49},"Azra Alizad, MD","CONTACT","507-538-1727","alizad.azra@mayo.edu",{"name":51,"role":47,"phone":52,"phoneExt":24,"email":53},"Fatima Zohra, MS","5075382234","Zohra.Fatima@mayo.edu",{"name":27,"role":28,"phone":24,"phoneExt":24,"email":24},{"type":28,"investigatorFullName":27,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Principal Investigator",[58],{"name":59,"class":60},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100589294","ultrasound-perfusion-estimation-for-assessment-of-peripheral-arterial-disease-100589294",false,"NCT06952543","Ultrasound Perfusion Estimation for Assessment of Peripheral Arterial Disease","Ultrasound Perfusion Estimation for Assessment of PAD","Inclusion Criteria:\n\nPatient volunteers:\n\n* Male and Female, ages 18 years old and up\n* Symptom of claudication and suspected for PAD\n* Scheduled for vascular testing.\n\nHealthy volunteers:\n\n* Male and female, ages 18-75 years old and up\n* Normal BMI\n* No history of smoking, cardiovascular disease, or diabetes.\n\nExclusion Criteria:\n\nPatient volunteers:\n\n* Patients with gangrene\n* Patients having surgery or stent\n* Patients with ulcer on their leg\n* Any health condition that does not allow proper use of ultrasound scanning\n* People considered in \"vulnerable\" populations.\n\nHealthy volunteers:\n\n* Include volunteers with BMI not more than 30\n* No history of smoking\n* No history of (diabetes, hypertension, cardiovascular diseases)\n* People considered in \"vulnerable\" populations.",true,"ALL","18 Years","75 Years",{"count":73,"type":74},400,"ESTIMATED","INTERVENTIONAL",[77],"NA","The purpose of this study is to develop a new noninvasive tool for early diagnosis of Peripheral Arterial Disease (PAD) and use the proposed method for monitoring the disease progression and the response to interventional treatment in PAD patients.",[80],"Peripheral Arterial Disease","2026-04-29",{"date":83,"type":84},"2026-05-05","ACTUAL",{"date":86,"type":84},"2025-03-14",{"date":88,"type":74},"2029-08-30",{"name":5,"class":6},1]