[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100552825":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":31,"locations":40,"responsibleParty":65,"collaborators":67,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":10,"studyType":84,"phases":10,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":43,"whyStopped":10,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"University of Exeter","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Case with confirmed disease-causing genetic change",null,"Cases with confirmed disease-causing genetic change that results in beta cells not working properly.\n\nConsent, collection of clinical data and blood samples, MRI (optional)",[13,14],"Other: Data and Blood collection","Other: MRI",{"label":16,"type":10,"description":17,"interventionNames":18},"Control (without the variant of interest)","Sex-matched controls with similar age and BMI (age +\u002F-15%, BMI +\u002F- 3 kg\u002Fm2). Consent, collection of clinical data and blood samples, MRI (optional)",[13,14],[20,23],{"type":6,"name":21,"description":21,"armGroupLabels":22,"otherNames":10},"Data and Blood collection",[9,16],{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"MRI","MRI (optional)",[9,16],[28],{"name":29,"affiliation":5,"role":30},"Andrew Hattersley, FRS, FMed","PRINCIPAL_INVESTIGATOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":10,"email":36},"Matthew Johnson, PhD","CONTACT","+44 (0) 1392 408277","m.johnson@exeter.ac.uk",{"name":38,"role":34,"phone":10,"phoneExt":10,"email":39},"Martin Eichmann, PhD","m.eichmann@exeter.ac.uk",[41],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Royal Devon University Healthcare NHS Foundation Trust","RECRUITING","Exeter","Devon","EX2 5DW","United Kingdom","UK",{"type":50,"coordinates":51},"Point",[52,53],-3.52751,50.7236,{"lat":53,"lon":52},[56,57,58,60,63],{"name":33,"role":34,"phone":35,"phoneExt":10,"email":36},{"name":38,"role":34,"phone":10,"phoneExt":10,"email":39},{"name":59,"role":30,"phone":10,"phoneExt":10,"email":10},"Andrew T Hattersley",{"name":61,"role":62,"phone":10,"phoneExt":10,"email":10},"Matthew Johnson","SUB_INVESTIGATOR",{"name":64,"role":62,"phone":10,"phoneExt":10,"email":10},"Martin Eichmann",{"type":66,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[68],{"name":69,"class":6},"Royal Devon and Exeter NHS Foundation Trust","100552825","understanding-beta-cell-disorders-through-the-study-of-rare-genotypes-endure-100552825",false,"NCT06478121","Understanding Beta Cell Disorders Through the Study of Rare Genotypes (ENDURE)","ENDURE","Inclusion Criteria\n\n* Mental capacity to give informed consent\n* Of any sex, ethnicity, location.\n* Group 1: Cases will have a genetic variant(s) resulting in a beta cell disorder.\n* Group 2: Controls will not have a genetic variant(s) resulting in a beta cell disorder and will be matched to a Case for sex, age (+\u002F- 15%) and BMI (+\u002F- 3 kg\u002Fm2).\n\nExclusion Criteria\n\n* Lack of mental capacity to give informed consent\n* Age \\\u003C6 years; \\>99 years\n\nAdditional exclusions for MRI assessments:\n\n* Cochlear Implant\n* Aneurysm Clips\n* Neurological stimulator\n* Implanted cardiac devices (ICD, PPM, loop recorders, or any others)\n* Metal heart valve\n* History of metal foreign bodies in orbits\n* Other implanted metal device which prevents MRI\n* Known claustrophobia.",true,"ALL","6 Years","99 Years",{"count":82,"type":83},50,"ESTIMATED","OBSERVATIONAL","This observational 'recruit by genotype' study aims to provide insights into the cellular and molecular pathways underlying beta cell disorders and their physiological consequences. Eligible individuals are those with and without a pathogenic genetic variant, acting as case and control, respectively. Using a \"recruit by genotype\" approach, the researchers will perform detailed and specific analysis according to the individual's genetic variant.\n\nThe study's main aims are to : 1) identify and describe biomarkers and cellular features in blood samples that occur because of the rare causal genetic variant; 2) study the altered physiology or cellular function that are due to the rare causal genetic variant.\n\nParticipants will attend a study visit that will entail:\n\n* Consent\n* Data collection\n* Height and weight measures\n* Blood samples\n* MRI (optional), dependent on genotype and sub-study objectives.\n\nThere is no treatment and the participants' normal clinical care will be unaffected and will continue uninterrupted.\n\nA small subset of participants may be invited for further sub-studies in the future. Researchers may recruit sex-matched healthy controls (without the variant of interest) with similar age and BMI (age: +\u002F-15%, BMI: +\u002F- 3 kg\u002Fm2) for specified case-control studies.",[87,88,89],"Diabetes Mellitus","Monogenic Diabetes","Hyperinsulinism",[88,89,91,92,93,94],"Beta cell disorders","Genotype-to-phenotype","Causal genetic variant","Beta cell","2026-01-14",{"date":97,"type":98},"2026-01-16","ACTUAL",{"date":100,"type":98},"2025-11-11",{"date":102,"type":83},"2029-02-28",{"name":5,"class":6},1]