[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603151":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":85,"centralContacts":89,"locations":99,"responsibleParty":118,"collaborators":120,"id":124,"slug":125,"hasResults":126,"nctId":127,"briefTitle":128,"officialTitle":128,"acronym":129,"eligibilityCriteria":130,"healthyVolunteers":126,"sex":131,"minAge":132,"maxAge":30,"enrollmentInfo":133,"targetDuration":30,"studyType":136,"phases":137,"briefSummary":139,"conditions":140,"keywords":142,"overallStatus":102,"whyStopped":30,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":154},{"fullName":5,"class":6},"University of Pennsylvania","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Low resistance exercise intervention","Participants will be asked to perform a series of exercises recommend by the National Institute on Aging Go4Life campaign, namely hand grip, overhead arm raise, arm curl, wall push-ups, and chair dips.",[12,13,14,15,16,17,18,19,20,21,22,23],"Diagnostic Test: blood draw","Diagnostic Test: Short Performance Physical Battery","Diagnostic Test: Grip strength test","Diagnostic Test: Six minute walk test","Radiation: Chest CT scan","Radiation: Dual-Energy X-ray Absorptiometry Scan","Behavioral: Activity monitoring","Behavioral: 24 hour diet recall","Diagnostic Test: Echocardiogram","Behavioral: Quality of Life Questionnaire (emPHasis 10)","Behavioral: International Physical Activity Questionnaire Short Form (IPAQ-SF)","Behavioral: Low resistance exercise intervention",[25,31,35,39,43,48,55,60,64,71,77,83],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DIAGNOSTIC_TEST","blood draw","Research blood draw",[9],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Short Performance Physical Battery","test of physical performance, which involves measuring movement from sitting to standing, walking speed, and balance",[9],{"type":26,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"Grip strength test","Measures grip strength",[9],{"type":26,"name":40,"description":41,"armGroupLabels":42,"otherNames":30},"Six minute walk test","Measures distance walked in 6 minutes",[9],{"type":44,"name":45,"description":46,"armGroupLabels":47,"otherNames":30},"RADIATION","Chest CT scan","X-ray and computer technology takes detailed pictures of the organs and structures inside your chest",[9],{"type":44,"name":49,"description":50,"armGroupLabels":51,"otherNames":52},"Dual-Energy X-ray Absorptiometry Scan","Uses X-ray technology to measure the mineral density of your bones, and provides a ratio of fat tissue to lean mass (muscle) and bone",[9],[53,54],"DXA Scan","DEXA Scan",{"type":56,"name":57,"description":58,"armGroupLabels":59,"otherNames":30},"BEHAVIORAL","Activity monitoring","A device worn on your non-dominant wrist which measures motion\u002F movement\u002F activity",[9],{"type":56,"name":61,"description":62,"armGroupLabels":63,"otherNames":30},"24 hour diet recall","A research dietitian will contact you and ask you to provide details of what you ate over the previous 24 hours",[9],{"type":26,"name":65,"description":66,"armGroupLabels":67,"otherNames":68},"Echocardiogram","Ultrasound technology to create moving images of your heart, valves, and chambers",[9],[69,70],"Echo","Cardiac Ultrasound",{"type":56,"name":72,"description":73,"armGroupLabels":74,"otherNames":75},"Quality of Life Questionnaire (emPHasis 10)","The emPHasis-10 is a pulmonary hypertension-specific questionnaire which is scored from 0-50 (with higher scores indicating worse quality of life.)",[9],[76],"emPHasis 10",{"type":56,"name":78,"description":79,"armGroupLabels":80,"otherNames":81},"International Physical Activity Questionnaire Short Form (IPAQ-SF)","The IPAQ-SF is a small set of questions to obtain comparable estimates of physical activity.",[9],[82],"IPAQ-SF",{"type":56,"name":9,"description":10,"armGroupLabels":84,"otherNames":30},[9],[86],{"name":87,"affiliation":5,"role":88},"Nadine Al-Naamani, MD","PRINCIPAL_INVESTIGATOR",[90,95],{"name":91,"role":92,"phone":93,"phoneExt":30,"email":94},"Rebecca Gallagher","CONTACT","215-294-9755","Rebecca.lang@Pennmedicine.upenn.edu",{"name":96,"role":92,"phone":97,"phoneExt":30,"email":98},"Nicole Denney, MS","215-615-4156","nicole.denney@pennmedicine.upenn.edu",[100],{"facility":101,"status":102,"city":103,"state":104,"zip":105,"country":106,"countryCode":107,"cosmosGeoPoint":108,"geoPoint":113,"contacts":114},"University of Pennsylvania Hospital","RECRUITING","Philadelphia","Pennsylvania","19104","United States","US",{"type":109,"coordinates":110},"Point",[111,112],-75.16362,39.95238,{"lat":112,"lon":111},[115,117],{"name":96,"role":92,"phone":30,"phoneExt":93,"email":116},"Nicole.denney@Pennmedicine.upenn.edu",{"name":87,"role":88,"phone":30,"phoneExt":30,"email":30},{"type":119,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR",[121],{"name":122,"class":123},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100603151","understanding-the-effects-of-pulmonary-arterial-hypertension-on-lean-muscle-mass-100603151",false,"NCT07132788","Understanding the Effects of Pulmonary Arterial Hypertension on Lean Muscle Mass","MUSCLE UP-PH","Inclusion Criteria:\n\n* Signed informed consent prior to initiation of any study mandated procedure.\n* Diagnosis of PAH belonging to one of the following subgroups of Group 1 PH according to the updated clinical classification \\[Humbert 2022\\]\n\n  * Idiopathic (IPAH)\n  * Heritable (HPAH)\n  * Drugs or toxins induced\n  * Associated (APAH) with one of the following:\n\n    * Connective tissue disease;\n    * Human immunodeficiency virus (HIV) infection;\n    * Congenital heart disease; or\n    * Portopulmonary hypertension\n* Diagnosis of PAH within 6 months of enrollment or diagnosis of PAH and on stable therapy for 3 months prior to enrollment\n* Documented hemodynamic diagnosis of PAH by right heart catheterization (RHC), prior to enrollment showing:\n\n  * mPAP \\> 20 mmHg; and\n  * PAWP or LVEDP ≤ 15 mmHg\n  * PVR \\> 2 Wood units\n\nExclusion Criteria:\n\n* Prior to enrollment, evidence of moderately severe obstructive ventilator defect with:\n\n  * FEV1\u002FFVC ≤ 5th percentile; and\n  * FEV1 z-score \\\u003C 2.5\n* Prior to enrollment, evidence of severe restrictive defect with\n\n  * TLC \\\u003C 5th percentile\n  * FEV1 z-score \\\u003C 4\n* Prior to enrollment, hospitalization (within 1 week) for decompensated right heart failure\n* More than moderate aortic or mitral valve disease\n* LVEF \\\u003C 40% within 1 year of screening\n* Pregnancy","ALL","18 Years",{"count":134,"type":135},150,"ESTIMATED","INTERVENTIONAL",[138],"NA","Patients with pulmonary arterial hypertension (PAH) are at increased risk of muscle loss and decreased physical activity. This study will aim to (1) understand the way in which muscle loss occurs in PAH, particularly the role of fat surrounding the heart, and (2) look at the impact muscle loss has on quality of life, daily physical activity, and hospitalizations in patients with PAH. The findings from this study could help identify potentially treatable factors that may improve the overall quality of life and physical functioning of patients with PAH.\n\nSubjects will be asked to attend a baseline visit where the following will be performed:\n\n* Measure your vital signs\n* Undergo a research blood draw, less than 4 tablespoons\n* Provide a urine pregnancy test (if applicable)\n* Review demographics, personal history, and medical history\n* Review current PAH medications\n* Complete questionnaires on how your PAH affects you\n* Complete a test of physical performance\n* Complete a grip strength test\n* Undergo an echocardiogram (Echo)\n* Complete a six-minute walk test\n* Undergo a Chest CT Scan\n* Undergo a scan of your body composition (DXA scan)\n* Obtain a weight and body composition measurement on the InBody Scale Subjects will also complete activity moniotring, two 24-hour diet recalls, and participate in remote follow-up visits every 6 months",[141],"Pulmonary Hypertension",[143,144],"pulmonary hypertension","body composition","2026-05-07",{"date":147,"type":148},"2026-05-11","ACTUAL",{"date":150,"type":148},"2025-05-01",{"date":152,"type":135},"2029-09-30",{"name":5,"class":6},1]