[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100552307":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":24,"locations":30,"responsibleParty":48,"collaborators":10,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":54,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":10,"studyType":66,"phases":10,"briefSummary":67,"conditions":68,"keywords":75,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"University of Cyprus","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Abstainers",null,"Participants who achieve biochemically-verified smoking abstinence for at least 6 months following a cessation attempt aided by a computerized intervention program.",[13],"Behavioral: Flexiquit Smoking Cessation Intervention",{"label":15,"type":10,"description":16,"interventionNames":17},"Relapsers","Participants who do not achieve abstinence and relapse to smoking following the cessation attempt.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"BEHAVIORAL","Flexiquit Smoking Cessation Intervention","Participants will enter a 6-week (once weekly) self-delivered computerized intervention program called Flexiquit. Developed and validated by Clinical Psychologists of the Department of Psychology at the University of Cyprus, Flexiquit is an avatar-led app designed to support smoking cessation. It aims to assist with abstinence and monitor participants' progress through personalized modules and assessments.",[9,15],[25],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Andrea N Georgiou, Ph.D.","CONTACT","(+357)-22893372","georgiou.andrea@ucy.a.cy",[31],{"facility":32,"status":33,"city":34,"state":10,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Center for Applied Neuroscience (CAN)","RECRUITING","Nicosia","2100","Cyprus","CY",{"type":39,"coordinates":40},"Point",[41,42],33.35397,35.17284,{"lat":42,"lon":41},[45],{"name":46,"role":27,"phone":10,"phoneExt":10,"email":47},"Andrea Georgiou, Ph.D.","georgiou.andrea@ucy.ac.cy",{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Panos Zanos","Assistant Professor","100552307","unraveling-the-genetic-basis-of-nicotine-addiction-for-novel-therapeutic-strategies-100552307",false,"NCT06471387","Unraveling the Genetic Basis of Nicotine Addiction for Novel Therapeutic Strategies","Exploring the Genetic and Molecular Underpinning of Nicotine Addiction for the Development of New Therapeutic Strategies","NicoGen","Inclusion Criteria:\n\n* Adults aged 18-60 years old\n* Current daily cigarette smoker\n* Able to understand study procedures and provide informed consent\n* For females, non-pregnant and non-lactating\n\nExclusion Criteria:\n\n* Presence of significant uncontrolled medical conditions (e.g. cardiovascular disease, respiratory disorders, cancer) that could affect smoking behaviors or study participation\n* Presence of major uncontrolled psychiatric disorders (e.g. schizophrenia, bipolar disorder, severe depression)\n* Current substance use disorder (except nicotine dependence)\n* Taking medications that could significantly interfere with study objectives (e.g. medications for smoking cessation)\n* Significant cognitive impairment that precludes ability to complete study procedures","ALL","18 Years","60 Years",{"count":64,"type":65},200,"ESTIMATED","OBSERVATIONAL","This case-control study aims to investigate the genetic and molecular bases of nicotine addiction to identify potential therapeutic targets. The project will involve drug repurposing using Mendelian Randomization, a smoking cessation intervention, and the analysis of methylation status in participants undergoing nicotine withdrawal.",[69,70,71,72,73,74],"Smoking Cessation","Smoking Cessation Intervention","Nicotine Addiction","Epigenetics","Molecular Biology","Genetic Epidemiology",[71,69,76,77,74,78,79],"Mendelian Randomization","Methylation","Drug Repurposing","Epigenetic Biomarkers","2024-06-23",{"date":82,"type":83},"2024-06-25","ACTUAL",{"date":85,"type":83},"2023-11-01",{"date":87,"type":65},"2025-10-31",{"name":5,"class":6},1]