[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100594955":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":33,"centralContacts":37,"locations":46,"responsibleParty":64,"collaborators":66,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":12,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":12,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":48,"whyStopped":12,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Australian Catholic University","OTHER",[8,13,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Control Trial","NO_INTERVENTION","A 6-day control trial. All participants will commence with this trial involving an energy availability of 40 kcal\u002Fkg fat-free mass (FFM). Energy intake will be 55 kcal\u002Fkg FFM\u002Fd and exercise energy expenditure will be 15 kcal\u002Fkg FFM\u002Fd. This will be followed by a minimum 3-week washout period where the participant will be advised to return to their routine diet and exercise.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Low Energy Availability - Diet","EXPERIMENTAL","A 6-day severe low energy availability (LEA, 15kcal\u002Fkg FFM\u002Fd) trial, achieved by superimposing restricted energy intake on the HEA trial. Energy intake will be 30 kcal\u002Fkg FFM\u002Fd and exercise energy expenditure will be 15 kcal\u002Fkg FFM\u002Fd. This will be followed by a minimum 3-week washout period where the participant will be advised to return to their routine diet and exercise.",[18],"Other: Diet-induced low energy availability",{"label":20,"type":15,"description":21,"interventionNames":22},"Low Energy Availability - Exercise","A 6-day severe low energy availability (LEA, 15kcal\u002Fkg FFM\u002Fd) trial, achieved by superimposing increased exercise energy expenditure on the HEA trial. Energy intake will be 45 kcal\u002Fkg FFM\u002Fd and exercise energy expenditure will be 30 kcal\u002Fkg FFM\u002Fd. This will be followed by a minimum 3-week washout period where the participant will be advised to return to their routine diet and exercise.",[23],"Other: Exercise-induced low energy availability",[25,29],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":12},"Diet-induced low energy availability","6-days of severe low energy availability (LEA, 15kcal\u002Fkg FFM\u002Fd), achieved by superimposing restricted energy intake on the control trial.",[14],{"type":6,"name":30,"description":31,"armGroupLabels":32,"otherNames":12},"Exercise-induced low energy availability","6-days of severe low energy availability (LEA, 15kcal\u002Fkg FFM\u002Fd), achieved by superimposing increased exercise energy expenditure on the control trial.",[20],[34],{"name":35,"affiliation":5,"role":36},"Louise M Burke, PhD","PRINCIPAL_INVESTIGATOR",[38,42],{"name":35,"role":39,"phone":40,"phoneExt":12,"email":41},"CONTACT","+61 4 22 635 869","louise.burke@acu.edu.au",{"name":43,"role":39,"phone":44,"phoneExt":12,"email":45},"Margot A Rogers, PhD","+61 4 47 958 373","margot.rogers@acu.edu.au",[47],{"facility":5,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"RECRUITING","Fitzroy","Victoria","3065","Australia","AU",{"type":55,"coordinates":56},"Point",[57,58],144.97833,-37.79839,{"lat":58,"lon":57},[61,63],{"name":43,"role":39,"phone":62,"phoneExt":12,"email":45},"+61 447 958 373",{"name":35,"role":36,"phone":12,"phoneExt":12,"email":12},{"type":65,"investigatorFullName":12,"investigatorTitle":12,"investigatorAffiliation":12,"oldNameTitle":12,"oldOrganization":12},"SPONSOR",[67],{"name":68,"class":69},"Wu Tsai Human Performance Alliance","UNKNOWN","100594955","unravelling-energy-issues-underpinning-low-energy-availability-in-high-performance-athletes-100594955",false,"NCT07026175","Unravelling Energy Issues Underpinning Low Energy Availability in High Performance Athletes","Inclusion Criteria:\n\n* 18-45 years old\n* Well trained weight-bearing athlete (tier 2-4 1)\n* Perform \\~45km per week of weight-bearing endurance training, and able to undertake the prescribed exercise in each trial condition\n* Pass the ESSA pre-exercise screening tool and\u002For obtain GP clearance to exercise\n\nExclusion Criteria:\n\n* Assessment of red status on the REDs Clinical Assessment Tool\n* Unable to attend ACU in Fitzroy, Victoria, for the 6 study visits for completion of the study protocol\n* Pregnancy\n* Use of hormonal contraceptive with the previous 3 months\n* Onset of peri\u002Fmenopause",true,"ALL","18 Years","45 Years",{"count":81,"type":82},20,"ESTIMATED","INTERVENTIONAL",[85],"NA","The goal of this clinical trial is to understand how the body responds to short-term, severe low energy availability (LEA) in healthy, weight-bearing endurance athletes aged 18-45 years old. LEA describes a mismatch between an individual's dietary energy intake and the energy cost of their commitments for training and competition. The main questions this trial aims to answer are:\n\n1. What effect does short-term, severe LEA have on sleeping metabolic rate?\n2. What effect does short-term, severe LEA have on other body systems identified within the Relative Energy Deficiency in Sport (REDs) Health and Performance Conceptual models?\n\nResearchers will compare a control trial with both a LEA trial achieved through diet restriction and a LEA trial achieved through increased exercise to see if there are differences in the body's response.\n\nParticipants will complete three 6-day trials, a minimum of 3-weeks apart, involving:\n\n* Prescribed diet (all food provided)\n* Prescribed running and\u002For cycling exercise\n* Two visits to ACU Fitzroy campus for blood tests and exercise testing\n* 50 hour stay (two nights and two days) in the ACU metabolic chamber",[88],"Relative Energy Deficiency in Sport",[90,91,92,93,94],"Relative Energy Deficiency in Sport (REDs)","Endurance","Athlete","Sleeping Metabolic Rate","Problematic Low Energy Availability","2025-06-10",{"date":97,"type":98},"2025-06-18","ACTUAL",{"date":100,"type":82},"2025-06",{"date":102,"type":82},"2027-06",{"name":5,"class":6},1]