[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100503106":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":37,"centralContacts":41,"locations":47,"responsibleParty":76,"collaborators":78,"id":82,"slug":83,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":27,"eligibilityCriteria":88,"healthyVolunteers":84,"sex":89,"minAge":90,"maxAge":27,"enrollmentInfo":91,"targetDuration":27,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":27,"overallStatus":49,"whyStopped":27,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"University of Florida","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Walking Exercise plus active tDCS","ACTIVE_COMPARATOR","The walking exercise will focus on use of complex walking tasks such as obstacle crossing, accurate foot placement, and walking on compliant surfaces. Each session will consist of 30 minutes of walking. Active tDCS will be delivered over prefrontal cortex.",[13,14],"Behavioral: Walking Exercise","Device: Prefrontal Active tDCS",{"label":16,"type":17,"description":18,"interventionNames":19},"Walking Exercise plus sham tDCS","SHAM_COMPARATOR","The walking exercise will focus on use of complex walking tasks such as obstacle crossing, accurate foot placement, and walking on compliant surfaces. Each session will consist of 30 minutes of walking. Sham tDCS will be delivered over prefrontal cortex.",[13,20],"Device: Prefrontal Sham tDCS",[22,28,33],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"BEHAVIORAL","Walking Exercise","aerobic walking exercise using complex (cognitively engaging) walking tasks",[9,16],null,{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":27},"DEVICE","Prefrontal Active tDCS","20 minutes of 2 milliamp transcranial direct current stimulation (tDCS) of prefrontal regions, delivered at each session",[9],{"type":29,"name":34,"description":35,"armGroupLabels":36,"otherNames":27},"Prefrontal Sham tDCS","30 seconds of 2 milliamp transcranial direct current stimulation (tDCS) of prefrontal regions, delivered at each session",[16],[38],{"name":39,"affiliation":5,"role":40},"David J Clark, ScD","PRINCIPAL_INVESTIGATOR",[42],{"name":39,"role":43,"phone":44,"phoneExt":45,"email":46},"CONTACT","352-376-1611","105244","davidclark@ufl.edu",[48,63],{"facility":5,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"RECRUITING","Gainesville","Florida","32610","United States","US",{"type":56,"coordinates":57},"Point",[58,59],-82.32483,29.65163,{"lat":59,"lon":58},[62],{"name":39,"role":43,"phone":44,"phoneExt":45,"email":46},{"facility":64,"status":49,"city":65,"state":51,"zip":66,"country":53,"countryCode":54,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"Brooks Rehabilitation","Jacksonville","32653",{"type":56,"coordinates":68},[69,70],-81.65565,30.33218,{"lat":70,"lon":69},[73],{"name":74,"role":43,"phone":27,"phoneExt":27,"email":75},"Emily J Fox, PhD","ejfox@phhp.ufl.edu",{"type":77,"investigatorFullName":27,"investigatorTitle":27,"investigatorAffiliation":27,"oldNameTitle":27,"oldOrganization":27},"SPONSOR",[79],{"name":80,"class":81},"National Institute on Aging (NIA)","NIH","100503106","up-2-study-cognitively-engaging-walking-exercise-and-neuromodulation-to-enhance-brain-function-in-older-adults-100503106",false,"NCT05830942","Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults","Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults","Inclusion Criteria:\n\n* Age 65+\n* Objective executive function decline, based on standardized cognitive assessments.\n* Subjective cognitive decline, based on the question: \"During the past 12 months, have you experienced confusion or memory loss that is happening more often or getting worse?\"\n* Ability to walking independently for 6 minutes (use of cane permitted)\n\nExclusion Criteria:\n\n* Major cognitive disorder that interferes with independence\n* Percentile score less than 10th percentile on standardized cognitive assessments\n* Medications that are thought to influence tDCS neuroplasticity.\n* Contraindications to tDCS or MRI.","ALL","65 Years",{"count":92,"type":93},120,"ESTIMATED","INTERVENTIONAL",[96],"NA","Declines in cognitive function and walking function are highly intertwined in older adults. A therapeutic approach that combines complex (cognitively engaging) aerobic walking exercise with non-invasive electrical brain stimulation may be effective at restoring lost function. This study tests whether electrical stimulation of prefrontal brain regions is more beneficial than sham stimulation.",[99,100,101],"Cognitive Dysfunction","Mobility Limitation","Frail Elderly","2026-06-02",{"date":104,"type":105},"2026-06-03","ACTUAL",{"date":107,"type":105},"2024-04-15",{"date":109,"type":93},"2027-04-30",{"name":5,"class":6},2]