[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100528404":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":24,"locations":30,"responsibleParty":46,"collaborators":23,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":23,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":23,"enrollmentInfo":59,"targetDuration":23,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":70,"overallStatus":33,"whyStopped":23,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Chinese University of Hong Kong","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"EUS-guided coeliac ganglion neurolysis \u002F celiac plexus neurolysis","ACTIVE_COMPARATOR","Patient would undergo a EUS diagnostic procedure with or without a biopsy. Patient would be blinded to the group they were assigned. The procedure will be performed with a linear array echoendoscope (EUS) under conscious sedation or monitored anaesthesia care.\n\nFor cases in which celiac ganglia could not be visualized, EUS-guided coeliac plexus neurolysis (CPN) will be performed.",[13],"Procedure: EUS-guided coeliac ganglion neurolysis \u002F celiac plexus neurolysis",{"label":15,"type":10,"description":16,"interventionNames":17},"Conventional step-up approach","Patient would undergo a EUS diagnostic procedure with or without a biopsy. Patient would be blinded to the group they were assigned. The concept of the conventional step-up approach is to follow ESMO clinical practice guidelines for cancer pain.\n\nIn case of inadequate pain control, the analgesics will be stepped up according to the guidelines. After 4 weeks, if patient's VAS score more than 7 or VAS score fails to improve by 20% despite optimal oral analgesics, patients are given the option of EUS-guided CGN\u002F CPN.",[13],[19],{"type":20,"name":9,"description":21,"armGroupLabels":22,"otherNames":23},"PROCEDURE","The EUS scope was first inserted into the stomach, and the coeliac trunk was visualized by scanning from the lesser curve of the gastric body. After visualization, the scope was rotated clockwise, enabling visualization and identification of the left adrenal gland. The coeliac ganglia are often seen to the left of the coeliac artery, between the aorta and the left adrenal gland, at the level between the coeliac artery and the left adrenal artery. They are also visualized cephalad to the coeliac artery in some cases. Hypoechoic nodular structures linked by hypoechoic threads residing in the periphery of this region were defined as the coeliac ganglia . A 19G or 22G needle was used for puncture of the CGN. After confirming the lack of backflow of blood with aspiration, a mixture of 5ml of 0.25-0.5% bupivacaine and 5ml absolute alcohol was injected.\n\nFor cases in which celiac ganglia could not be visualized, EUS-guided coeliac plexus neurolysis (CPN) will be performed.",[15,9],null,[25],{"name":26,"role":27,"phone":28,"phoneExt":23,"email":29},"Shannon Melissa Chan","CONTACT","852-35052627","shannonchan@surgery.cuhk.edu.hk",[31],{"facility":32,"status":33,"city":34,"state":34,"zip":35,"country":34,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Prince of Wales Hospital","RECRUITING","Hong Kong","00000","HK",{"type":38,"coordinates":39},"Point",[40,41],114.17469,22.27832,{"lat":41,"lon":40},[44],{"name":45,"role":27,"phone":28,"phoneExt":23,"email":29},"Shannon M Chan, FRCS",{"type":47,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"PRINCIPAL_INVESTIGATOR","CHAN SHANNON MELISSA","Assistant Professor","100528404","upfront-eus-cgncpn-vs-conventional-step-up-approach-for-inoperable-painful-pancreatic-cancer-100528404",false,"NCT06160323","Upfront EUS CGN\u002FCPN vs Conventional Step up Approach for Inoperable Painful Pancreatic Cancer","Upfront Endoscopic Ultrasound-guided Celiac Ganglion Neurolysis Versus Conventional Step-up Approach for Patients With Painful, Inoperable Pancreatic Cancer","Inclusion Criteria:\n\n1. Age \\>= 18 years old\n2. Diagnosed to have inoperable pancreatic cancer\n3. Presence of tumor pain (centrally located, constant, with no other obvious cause) with a VAS \\>= 3\n4. Karnofsky performance status \\>= 60\n5. Planned for EUS examination and\u002For biopsy of the pancreatic tumor\n\nExclusion Criteria:\n\n1. Allergy to bupivacaine, or alcohol\n2. Potentially operable after neoadjuvant therapy\n3. Expected survival of less than 3 months\n4. Patient who is already on opioids for pain control\n5. Previous percutaneous or EUS-guided CGN\u002F CPN\n6. Recurrent pancreatic tumors after operation\n7. Uncorrectable coagulopathy\n8. Inability or unwillingness to provide informed consent","ALL","18 Years",{"count":60,"type":61},94,"ESTIMATED","INTERVENTIONAL",[64],"NA","Patients with unresectable pancreatic cancer are often demoralized by intractable, persistent and incapacitating pain. It must be managed aggressively and strong opioids are recommended as the mainstay of treatment. However, patients develop opioid-related adverse effects. EUS-guided celiac plexus neurolysis (CPN) and celiac ganglion neurolysis (CGN) has been shown to provide high efficacy for pain control. The optimal timing, however, is in debate.",[67,68,69],"Pancreatic Cancer Non-resectable","Tumor Pancreas","Pain Cancer",[67,71,72],"tumor pain","endoscopic ultrasound-guided celiac ganglion neurolysis","2026-05-04",{"date":75,"type":76},"2026-05-06","ACTUAL",{"date":78,"type":76},"2023-11-10",{"date":80,"type":61},"2028-07-31",{"name":5,"class":6},1]