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Ospedale di Circolo e Fondazione Macchi","Varese","21100",{"type":28,"coordinates":201},[202,203],8.82511,45.82058,{"lat":203,"lon":202},[206,210],{"name":207,"role":16,"phone":208,"phoneExt":7,"email":209},"Corrado Chiappa, MD","+39 0332 278342","corrado.chiappa@asst-settelaghi.it",{"name":207,"role":39,"phone":7,"phoneExt":7,"email":7},{"facility":212,"status":22,"city":213,"state":214,"zip":215,"country":214,"countryCode":216,"cosmosGeoPoint":217,"geoPoint":221,"contacts":222},"Ente Ospedaliero Cantonale","Lugano","Switzerland","CH-6500","CH",{"type":28,"coordinates":218},[219,220],8.96004,46.01008,{"lat":220,"lon":219},[223,227],{"name":224,"role":16,"phone":225,"phoneExt":7,"email":226},"Nickolas Peradze, MD","+41 (0)91 811 76 96","Nickolas.Peradze@eoc.ch",{"name":224,"role":39,"phone":7,"phoneExt":7,"email":7},{"type":229,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100614371","upfront-targeted-axillary-dissection-for-luminal-breast-cancer-with-limited-axillary-involvement-100614371",false,"NCT07278726","Upfront Targeted Axillary Dissection for Luminal Breast Cancer With Limited Axillary Involvement","Upfront Targeted Axillary Dissection for Luminal Breast Cancer With Limited Axillary Involvement: the UTAD Study of the Italian National Association of Breast Surgeons (ANISC)","UTAD","Inclusion Criteria:\n\n* Diagnosis of T0-T1-T2 ER+\u002FPR+ HER2- breast cancer with limited nodal involvement (1 or 2 suspicious lymph node on US, with at least 1 nodal positive cytology\u002Fhistology)\n* M0\n* Conservative surgery or mastectomy\n* Neoadjuvant treatment not recommended after a multidisciplinary discussion\n* Patients between 18 and 90 years old\n* Patients willing and able to follow the study procedures and available for follow-up over the entire duration of the study\n\nExclusion Criteria:\n\n* Psychiatric, addictive or any disorder, which compromises ability to give informed consent for participation in the study\n* Personal history of invasive breast cancer\n* Other invasive malignancies diagnosed in the last five years\n* Any condition that may expose the individual to a higher risk or preclude the study from achieving full compliance or completion\n* Contraindications to radiation therapy","ALL","18 Years","90 Years",{"count":242,"type":243},150,"ESTIMATED","OBSERVATIONAL","The present study aims to avoid axillary lymph node dissection (ALND) in patients with an Ultrasound (US) detected positive preoperative lymph node involvement (1 or 2 suspicious lymph-nodes) and a needle histology\u002Fcytology placing a marker in the most suspicious node undergoing upfront surgery if neoadjuvant treatment is not indicated. The marked lymph node will be retrieved along with sentinel lymphnode(SLN)(s) to minimize the false-negative rate and only in case of ≥3 positive SLNs ALND will be performed, in order to minimize surgical overtreatment among women with preoperatively confirmed axillary nodal metastasis.",[247,248,249],"ALND","Sentinel Lymph Node Biopsy (SLNB)","Targeted Axillary Dissection (TAD)","2026-06-15",{"date":252,"type":253},"2026-06-16","ACTUAL",{"date":255,"type":253},"2026-01-28",{"date":257,"type":243},"2033-11",{"name":5,"class":6},14]