[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100575727":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":24,"centralContacts":28,"locations":33,"responsibleParty":50,"collaborators":19,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":19,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":19,"overallStatus":36,"whyStopped":19,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Cliniques universitaires Saint-Luc- Université Catholique de Louvain","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Chronic rhinosinusitis patients","EXPERIMENTAL","Patients suffering from chronic rhinosinusitis will undergo smell testing as well as nasal brushing of the olfactory cleft",[13,14],"Other: Nasal brushing of the olfactory cleft","Other: Smell testing",[16,20],{"type":6,"name":17,"description":17,"armGroupLabels":18,"otherNames":19},"Nasal brushing of the olfactory cleft",[9],null,{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":19},"Smell testing","Smell testing using the Sniffin' Sticks Test",[9],[25],{"name":26,"affiliation":5,"role":27},"Valérie Hox, MD, PhD","PRINCIPAL_INVESTIGATOR",[29],{"name":26,"role":30,"phone":31,"phoneExt":19,"email":32},"CONTACT","+3227648675","valerie.hox@saintluc.uclouvain.be",[34],{"facility":35,"status":36,"city":37,"state":19,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Cliniques Universitaires Saint-Luc","RECRUITING","Brussels","1200","Belgium","BE",{"type":42,"coordinates":43},"Point",[44,45],4.34878,50.85045,{"lat":45,"lon":44},[48],{"name":49,"role":30,"phone":31,"phoneExt":19,"email":32},"Pr. Valérie Hox",{"type":51,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100575727","upper-airway-inflammation-and-olfaction-mechanisms-of-loss-and-recovery-100575727",false,"NCT06776042","Upper Airway Inflammation and Olfaction: Mechanisms of Loss and Recovery","IMMUNODOR","Inclusion Criteria:\n\n* At least two of the following symptoms: nasal obstruction, rhinorrhoea, smell loss, facial pain for 12 weeks.\n* Endoscopic visualisation of bilateral sinonasal polyps\n* SSI (TDI) \\\u003C 30.75 and decreased sense of smell subjectively\n* Eosinophilia \\> 300\u002Fμl of blood Ku\u002Fl\n* On a stable nasal steroid treatment for at least 4 weeks\n\nExclusion Criteria:\n\n* Active smoking\n* Primary and secondary immune deficiencies\n* Ciliary diseases (cystic fibrosis, primary ciliary diskinesia)\n* History of or current nasal malignancies\n* \\\u003C 18 years and \\> 70 years\n* Patients unable to express consent\n* Use of systemic corticosteroids for \\\u003C 4 weeks before visit 1 • Use of systemic or local antibiotics for \\\u003C 4 weeks before visit 1",true,"ALL","18 Years","70 Years",{"count":64,"type":65},140,"ESTIMATED","INTERVENTIONAL",[68],"NA","The goal of this clinical trial is to understand the mechanisms leading to olfactory dysfunction (OD) in chronic rhinosinusitis (CRS). The main questions it aims to answer are:\n\n* Is the type 2 inflammation impacting the olfactory epithelium regeneration, leading to OD?\n* Does a treatment interfering with one of the major T2 inflammatory cytokines, have an impact on the mechanisms of OD in CRS?\n\nParticipants will undergo olfactory testing and nasal brushing before and after 3 months of treatment.",[71],"Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)","2026-04-24",{"date":74,"type":75},"2026-04-27","ACTUAL",{"date":77,"type":75},"2023-05-22",{"date":79,"type":65},"2026-09-30",{"name":5,"class":6},1]