[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636872":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":31,"responsibleParty":49,"collaborators":20,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":20,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":60,"maxAge":20,"enrollmentInfo":61,"targetDuration":20,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":34,"whyStopped":20,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Universidad Autonoma de Nuevo Leon","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"1 arm, superior lacrimal punctal occlusion with plug in patients with aqueous-deficient dry eye who","EXPERIMENTAL","1 arm, superior lacrimal punctal occlusion with plug in patients with aqueous-deficient dry eye who have previously occlusion of the inferior lacrimal punctum.",[13],"Procedure: Punctal plug occlusion",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Punctal plug occlusion","Superior lacrimal punctal occlusion with plug in patients with aqueous-deficient dry eye who have previously occlusion of the inferior lacrimal punctum.",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Karim Mohamed-Noriega, Dr. med.","PRINCIPAL_INVESTIGATOR",[26],{"name":23,"role":27,"phone":28,"phoneExt":29,"email":30},"CONTACT","+52 8113404960","8514","karim.mohamednr@uanl.edu.mx",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Ophthalmology Department","RECRUITING","Monterrey","Nuevo León","64460","Mexico","MX",{"type":41,"coordinates":42},"Point",[43,44],-100.31721,25.68435,{"lat":44,"lon":43},[47],{"name":23,"role":27,"phone":28,"phoneExt":29,"email":48},"karim.mohamednrg@uanl.edu.mx",{"type":24,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Karim Mohamed-Noriega","Principal Investigator","100636872","upper-punctal-plug-occlusion-in-previous-lower-punctal-occlusion-100636872",false,"NCT07571330","Upper Punctal Plug Occlusion in Previous Lower Punctal Occlusion.","Effectiveness of Upper Punctal Plug Occlusion in Patients With Dry Eye Disease With Previous Lower Punctal Occlusion.","Inclusion Criteria:\n\n* Patients of both sexes\n* One or both eyes may be included\n* Inferior lacrimal punctum occluded (with a punctal plug or cauterization), clinically sealed under slit-lamp examination\n* Functional superior lacrimal punctum\n* Aqueous-deficient dry eye (such as Sjögren's disease, graft-versus-host disease, or primary dry eye disease.)\n* Age \\>18 years\n* OSDI score \\>13 and one of the following signs: Tear film markers (Fluorescein tear break up-time \\\u003C5, First non-invasive tear breakup time \\\u003C10, Schirmer test without anesthesia \\\u003C10 mm, Schirmer test with anesthesia \\\u003C10 mm), Ocular surface markers (corneal staining \\>5 spots or conjunctival staining \\>9 spots).\n\nExclusion Criteria:\n\n* Active ocular surface infection.\n* Patients who are unwilling to participate or to provide written informed consent.","ALL","18 Years",{"count":62,"type":63},36,"ESTIMATED","INTERVENTIONAL",[66],"NA","This study evaluates the therapeutic effect of upper punctal plug occlusion in patients with dry eye disease with previous lower punctal occlusion.",[69,70],"DED","Aqueous-deficient Dry Eye Disease",[72,69,73,74],"Aqueous-deficient dry eye disease","Punctual plug","Superior punctual plug","2026-05-04",{"date":77,"type":78},"2026-05-06","ACTUAL",{"date":80,"type":78},"2026-02-12",{"date":82,"type":63},"2026-11-01",{"name":5,"class":6},1]