[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100501237":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":33,"locations":38,"responsibleParty":66,"collaborators":68,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":77,"sex":83,"minAge":84,"maxAge":18,"enrollmentInfo":85,"targetDuration":18,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":18,"overallStatus":41,"whyStopped":18,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"University of Alberta","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention","EXPERIMENTAL","The proposed experimental intervention will incorporate our risk prediction model which will be used in combination with a patients medical profile to guide the hospital to home transition of care for low, medium and high-risk groups of patients. Patients will receive transition of care plans that are tailored to their medical profile and embedded within standardized discharge pathways within the electronic health record",[13],"Other: Risk-guided transition of care intervention delivered through an integrated digital health strategy",{"label":15,"type":16,"description":17,"interventionNames":18},"Usual Care","NO_INTERVENTION","The usual care group will not receive the risk-guided transition of intervention and will receive standard hospital discharge care in accordance with local health system standards (Alberta Health Services), with recommendations for kidney function, proteinuria and laboratory testing at 90 days after discharge.",null,[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":18},"Risk-guided transition of care intervention delivered through an integrated digital health strategy","Patients will receive transition of care plans that are tailored to their medical profile and risk and embedded within standardized discharge pathways within the EHR- Education and self-management guidance about AKI for patients, Medication guidance based on evidence-based indications for reducing risk of cardiac and kidney outcomes, Recommendations for subsequent laboratory testing of kidney function, proteinuria and electrolytes according to clinical characteristics and risks, Recommendations for timing and nature of PCP follow-up, Information about the patient's AKI and subsequent management provided to PCPs through discharge summary, Recommendations for outpatient Pharmacy follow-up for medication reconciliation and review according to patient risk and medication management gaps, Recommendations for Nephrology referral for high risk patients",[9],[25,28,31],{"name":26,"affiliation":5,"role":27},"Neesh Pannu","PRINCIPAL_INVESTIGATOR",{"name":29,"affiliation":30,"role":27},"Matthew James","University of Calgary",{"name":32,"affiliation":30,"role":27},"Tyrone Harrison",[34],{"name":26,"role":35,"phone":36,"phoneExt":18,"email":37},"CONTACT","780 492 8519","npannu@ualberta.ca",[39,56],{"facility":40,"status":41,"city":42,"state":43,"zip":18,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Foothills Medical Centre","RECRUITING","Calgary","Alberta","Canada","CA",{"type":47,"coordinates":48},"Point",[49,50],-114.08529,51.05011,{"lat":50,"lon":49},[53],{"name":54,"role":35,"phone":18,"phoneExt":18,"email":55},"Matt James","mjames@ucalgary.ca",{"facility":57,"status":41,"city":58,"state":43,"zip":18,"country":44,"countryCode":45,"cosmosGeoPoint":59,"geoPoint":63,"contacts":64},"University of Alberta Hospital","Edmonton",{"type":47,"coordinates":60},[61,62],-113.46871,53.55014,{"lat":62,"lon":61},[65],{"name":26,"role":35,"phone":18,"phoneExt":18,"email":37},{"type":67,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[69,71,74],{"name":70,"class":6},"Alberta Health services",{"name":72,"class":73},"Canadian Institutes of Health Research (CIHR)","OTHER_GOV",{"name":30,"class":6},"100501237","uptake-using-personalized-risk-and-digital-tools-to-guide-transitions-following-acute-kidney-events-100501237",false,"NCT05806645","UPTAKE: Using Personalized Risk and Digital Tools to Guide Transitions Following Acute Kidney Events","UPTAKE: Using Personalized Risk and Digital Tools to Guide Transitions Following Acute Kidney Events- A Pragmatic Randomized Controlled Trial in Connect Care","UPTAKE-1","Inclusion Criteria:\n\n(all of)\n\n* Age ≥ 18 years old\n* Hospitalized at site using AHS EHR\n* Acute Kidney Injury (Stage 1-3) identified in hospital per KDIGO guideline criteria\n\nExclusion Criteria:\n\n(any of)\n\n* Pre-hospitalization advanced CKD: eGFR\\\u003C30 mL\u002Fmin\u002F1.73m2\n* Pre-hospitalization dialysis\n* Very low risk (\\\u003C1% risk) of advanced CKD\n* Non-Alberta resident\n* Palliative goals of care\n* Enrolled in the UPTAKE VC Trial\n* Admitted under a nephrologist at time of discharge\n* Dialysis on at least 2 days in the last week prior to discharge\n* Receiving apheresis\n* Kidney transplant recipient\n* Kidney transplant donor\n* Diagnosis of Glomerulonephritis\n* Cirrhosis AND complication of cirrhosis in medical history or active problem list (ascites, varices, hepatic encephalopathy, hepatorenal syndrome)","ALL","18 Years",{"count":86,"type":87},6046,"ESTIMATED","INTERVENTIONAL",[90],"NA","Nearly one in ten people who are hospitalized in Canada develop a complication with sudden loss of kidney function, called acute kidney injury (AKI). AKI may lead to other severe health problems after discharge home, such as kidney failure requiring dialysis treatment, heart failure, heart attacks, stroke, and even premature death. Discharge from hospital to home can be a difficult transition where there are often gaps in identification, communication, care coordination, education, and planning of care for AKI. The study team will co-design and evaluate a tailored post-discharge care plan that is based on the risk of later kidney problems and uses currently available, yet untapped digital innovation to improve the health and experience of people with AKI.\n\nThis study will be built into Alberta's new Epic Systems based provincial electronic health record (EHR). The plan is to use digital tools in the EHR to identify all people in Alberta hospitals that have had an AKI event and are at increased risk of long-term complications. Half will randomly be assigned to receive a tailored care plan based on their risk at hospital discharge while the other half will receive care as it is currently provided by their healthcare team. The electronic health system will automatically calculate a patient's risk and report this risk in their chart along with recommendations for care. The study team includes patients, healthcare providers, and health system decision makers needed to co-develop the proposed strategy and introduce the changes needed to deliver this intervention. The investigators will study whether this strategy can reduce health problems that may happen after AKI including death, chronic kidney disease (CKD), kidney failure, heart attacks, and stroke. The investigators will also determine if the approach improves patient experience during the transition from hospital to home. This study has the potential to revolutionize how we care for people that leave hospital after having AKI.",[93],"Acute Kidney Injury","2026-06-08",{"date":96,"type":97},"2026-06-10","ACTUAL",{"date":99,"type":97},"2025-02-12",{"date":101,"type":87},"2029-09",{"name":5,"class":6},2]