[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577556":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":38,"responsibleParty":59,"collaborators":12,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":12,"enrollmentInfo":70,"targetDuration":12,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":81,"overallStatus":55,"whyStopped":12,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Universitätsklinikum Hamburg-Eppendorf","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Routine hemodynamic management","NO_INTERVENTION","In patients assigned to routine hemodynamic management, hemodynamic management will be performed according to routine care. The urethral perfusion index measurements will not be visible.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Urethral perfusion index guided hemodynamic monitoring","EXPERIMENTAL","In patients assigned to urethral perfusion index-guided hemodynamic monitoring, clinicians will be asked to maintaining the intraoperative urethral perfusion index above the postinduction baseline urethral perfusion index during surgery. Interventions to maintain intraoperative urethral perfusion index will be at the clinicians' discretion. All other medical procedures will be performed according to routine care. Clinical judgement will always prevail. Additionally, we will always strive to maintain macrocirculatory variables within predefined safety ranges: Mean arterial pressure: 60 mmHg - 120 mmHg Heart rate: 30 bpm - 120 bpm Cardiac index: at least 2.2 L\u002Fmin\u002Fm2",[18],"Device: urethal perfusion index monitoring",[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":12},"DEVICE","urethal perfusion index monitoring","The urethral perfusion index will be monitored using the IKORUS System (Vygon, Écouen, France)",[14],[26],{"name":27,"affiliation":28,"role":29},"Bernd Saugel, MD","University Medical Center Hamburg Eppendorf, Hamburg, Germany and OUTCOMES RESEARCH Consortium®, Houston, Texas, USA","PRINCIPAL_INVESTIGATOR",[31,35],{"name":27,"role":32,"phone":33,"phoneExt":12,"email":34},"CONTACT","+49741052415","b.saugel@uke.de",{"name":36,"role":32,"phone":33,"phoneExt":12,"email":37},"Moritz Flick, MD","m.flick@uke.de",[39,54],{"facility":40,"status":41,"city":42,"state":12,"zip":12,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"University Medical Center Hamburg-Eppendorf","NOT_YET_RECRUITING","Hamburg","Germany","DE",{"type":46,"coordinates":47},"Point",[48,49],9.99302,53.55073,{"lat":49,"lon":48},[52],{"name":27,"role":32,"phone":53,"phoneExt":12,"email":34},"+49 (0) 40 7410 - 52415",{"facility":40,"status":55,"city":42,"state":12,"zip":12,"country":43,"countryCode":44,"cosmosGeoPoint":56,"geoPoint":58,"contacts":12},"RECRUITING",{"type":46,"coordinates":57},[48,49],{"lat":49,"lon":48},{"type":60,"investigatorFullName":12,"investigatorTitle":12,"investigatorAffiliation":12,"oldNameTitle":12,"oldOrganization":12},"SPONSOR","100577556","urethral-perfusion-index-guided-hemodynamic-management-in-patients-having-major-abdominal-surgery-the-upright-randomized-feasibility-trial-100577556",false,"NCT06799832","Urethral PeRfusion Index-Guided Hemodynamic ManagemenT in Patients Having Major Abdominal Surgery: the UPRIGHT Randomized Feasibility Trial","UPRIGHT","Inclusion Criteria:\n\n* at least 45 years old\n* scheduled for elective major abdominal surgery (involving visceral organs with an expected duration of at least 120 minutes)\n* indication for an arterial catheter\n* indication for an urinary catheter\n\nExclusion Criteria:\n\n* Pregnancy\n* Planned surgery: nephrectomy, liver or kidney transplantation surgery\n* Patients who previously had surgery on the urethra or bladder\n* Patients without clinical indication for continuous blood pressure monitoring with an intraarterial catheter","ALL","45 Years",{"count":71,"type":72},116,"ESTIMATED","INTERVENTIONAL",[75],"NA","We will perform this single-center pilot trial to determine if the intraoperative urethral perfusion index is higher in patients assigned to maintaining postinduction baseline urethral perfusion index than in patients assigned to routine care (with blinded urethral perfusion index monitoring). As pre-planned substudies, we will also assess the agreement between a) urethral perfusion index-derived pulse rate and heart rate measured with an electrocardiogram and b) between the urethral perfusion index and the peripheral perfusion index.",[78,79,80],"Urethral Perfusion Index","Tissue Perfusion","Microcirculation",[82,83,84],"urethral perfusion index","tissue perfusion","microcirculation","2025-02-19",{"date":87,"type":88},"2025-02-21","ACTUAL",{"date":90,"type":88},"2025-01-21",{"date":92,"type":72},"2025-07-31",{"name":5,"class":6},2]